The epitranscriptome of long noncoding RNAs in metabolic diseases

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

(2020) Xiao Yang et al.   Molecular Cancer

SPEN integrates transcriptional and epigenetic control of X-inactivation

(2020) François Dossin et al.   NATURE

Author Correction: Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA

(2020) Henan Xu et al.   NATURE IMMUNOLOGY

Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery

(2020) Lekha Nair et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted point mutations of the m6A modification in miR675 using RNA-guided base editing induce cell apoptosis

(2020) Jindong Hao et al.   BIOSCIENCE REPORTS

lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR ‐7

(2020) Yan Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The RNA modification N6-methyladenosine as a novel regulator of the immune system

(2020) Ziv Shulman et al.   NATURE IMMUNOLOGY

Identification of The Long Non-Coding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension

(2020) Junichi Omura et al.   CIRCULATION

LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway

(2020) Cheng-Gong Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hematopoietic Deficiency of the Long Non-Coding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

(2019) Sebastian Cremer et al.   CIRCULATION

ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function

(2019) Nelli Baal et al.   JOURNAL OF IMMUNOLOGY

Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation

(2019) Tim Pollex et al.   NATURE GENETICS

Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens

(2019) Takahira Shirahase et al.   Frontiers in Behavioral Neuroscience

Epitranscriptomic Signatures in lncRNAs and Their Possible Roles in Cancer

(2019) Sorina Dinescu et al.   Genes

Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

(2019) Katherine Bohnsack et al.   Genes

The Pseudogene Olfr29-ps1 Promotes the Suppressive Function and Differentiation of Monocytic MDSCs

(2019) Wencong Shang et al.   Cancer Immunology Research

Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the “dark side” of addiction

(2019) Qian Peng et al.   Translational Psychiatry

The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders

(2019) John Peyton Bohnsack et al.   Translational Psychiatry

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

(2019) Juan Liu et al.   IMMUNITY

Phenotype and Environment Matter: Discovering the Genetic and Epigenetic Architecture of Alcohol Use Disorders

(2019) Jonathan D. Pollock et al.   AMERICAN JOURNAL OF PSYCHIATRY

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3

(2019) Zi-Qi Zheng et al.   CANCER RESEARCH

Transcriptome-wide analysis of pseudouridylation of mRNA and non-coding RNAs in Arabidopsis

(2019) Lirong Sun et al.   JOURNAL OF EXPERIMENTAL BOTANY

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

(2019) Jun Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework

(2019) George F. Koob et al.   NEUROPSYCHOPHARMACOLOGY

Long non-coding RNA Rpph1 promotes inflammation and proliferation of mesangial cells in diabetic nephropathy via an interaction with Gal-3

(2019) Panyang Zhang et al.   Cell Death & Disease

A single‐cell transcriptome atlas of the adult human retina

(2019) Samuel W Lukowski et al.   EMBO JOURNAL

Alcohol use disorders

(2019) Andre F Carvalho et al.   LANCET

LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

(2019) Jijun Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

(2019) Wen Ni et al.   Molecular Cancer

Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity

(2019) Shalom Hillel Roth et al.   NATURE METHODS

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction

(2019) Nenja Krüger et al.   CIRCULATION RESEARCH

The m6A epitranscriptome: transcriptome plasticity in brain development and function

(2019) Ido Livneh et al.   NATURE REVIEWS NEUROSCIENCE

Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes

(2019) Casslynn W. Q. Koh et al.   Nature Communications

m6A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells

(2019) Gege Yan et al.   Molecular Therapy-Nucleic Acids

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males

(2018) Elsa J. Sousa et al.   Cell Stem Cell

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential

(2018) Dandan Yang et al.   NUCLEIC ACIDS RESEARCH

Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease

(2018) Bo Yu et al.   Theranostics

Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency

(2018) Annita Louloupi et al.   Cell Reports

The Long Non-coding RNA MEG3/miR-let-7c-5p Axis Regulates Ethanol-Induced Hepatic Steatosis and Apoptosis by Targeting NLRC5

(2018) Qin Wang et al.   Frontiers in Pharmacology

Processing and roles of snoRNA-ended long noncoding RNAs

(2018) Yu-Hang Xing et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs

(2018) Simone Rauch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epitranscriptomic Code and Its Alterations in Human Disease

(2018) Rajashekar Varma Kadumuri et al.   TRENDS IN MOLECULAR MEDICINE

Structural insights into the RNA methyltransferase domain of METTL16

(2018) Agnieszka Ruszkowska et al.   Scientific Reports

Mechanistic insights into m6A RNA enzymes

(2018) Tina Lence et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

(2018) Yunshu Wu et al.   Nature Communications

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

(2018) Lukas Trixl et al.   Wiley Interdisciplinary Reviews-RNA

The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs

(2017) Roland Jacob et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene regulation of mammalian long non-coding RNA

(2017) Heeyoun Bunch   MOLECULAR GENETICS AND GENOMICS

An atlas of human long non-coding RNAs with accurate 5′ ends

(2017) Chung-Chau Hon et al.   NATURE

Epitranscriptome sequencing technologies: decoding RNA modifications

(2017) Xiaoyu Li et al.   NATURE METHODS

Metabolomics for clinical use and research in chronic kidney disease

(2017) Berthold Hocher et al.   Nature Reviews Nephrology

CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation

(2017) Minghui Yue et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs

(2017) Rakesh David et al.   PLANT CELL

Metabolism disrupting chemicals and metabolic disorders

(2017) Jerrold J. Heindel et al.   REPRODUCTIVE TOXICOLOGY

The New RNA World: Growing Evidence for Long Noncoding RNA Functionality

(2017) Allison Jandura et al.   TRENDS IN GENETICS

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

(2017) Iain M. Dykes et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

(2016) Kevin J. Kauffman et al.   BIOMATERIALS

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

(2016) Q Chen et al.   CELL DEATH AND DIFFERENTIATION

Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity

(2016) Shengjuan Wei et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy

(2016) Christian Bär et al.   CIRCULATION

RNA polymerase II promoter-proximal pausing in mammalian long non-coding genes

(2016) Heeyoun Bunch et al.   GENOMICS

N 6 -Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding

(2016) Katherine I. Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Long Noncoding RNAs

(2016) Reinier A. Boon et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

RNA modifications: what have we learned and where are we headed?

(2016) Michaela Frye et al.   NATURE REVIEWS GENETICS

Evolution to the rescue: using comparative genomics to understand long non-coding RNAs

(2016) Igor Ulitsky   NATURE REVIEWS GENETICS

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

Long noncoding RNAs in kidney and cardiovascular diseases

(2016) Johan M. Lorenzen et al.   Nature Reviews Nephrology

Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

(2016) Jessica A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

(2016) B. Delatte et al.   SCIENCE

Long noncoding RNAMALAT1-derived mascRNA is involved in cardiovascular innate immunity

(2016) Martina Gast et al.   Journal of Molecular Cell Biology

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL)

(2016) Gang Chen et al.   Scientific Reports

Long ncRNA expression associates with tissue-specific enhancers

(2015) Dubravka Vučićević et al.   CELL CYCLE

Formation and Abundance of 5-Hydroxymethylcytosine in RNA

(2015) Sabrina M. Huber et al.   CHEMBIOCHEM

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome

(2015) Xiaoyu Li et al.   Nature Chemical Biology

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4

(2015) Valeria Ranzani et al.   NATURE IMMUNOLOGY

Transcriptome-wide dynamics of RNA pseudouridylation

(2015) John Karijolich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NONCODE 2016: an informative and valuable data source of long non-coding RNAs

(2015) Yi Zhao et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

Long Noncoding RNAs in Patients With Acute Myocardial Infarction

(2014) Mélanie Vausort et al.   CIRCULATION RESEARCH

SRA Gene Knockout Protects against Diet-induced Obesity and Improves Glucose Tolerance

(2014) Shannon Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

(2014) Thomas M. Carlile et al.   NATURE

Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation

(2014) Adeline Divoux et al.   Obesity

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

(2014) Matthew N Davies et al.   GENOME BIOLOGY

Human alcohol-related neuropathology

(2013) Suzanne M. de la Monte et al.   ACTA NEUROPATHOLOGICA

Identification of a Selective Polymerase Enables Detection of N6-Methyladenosine in RNA

(2013) Emily M. Harcourt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of direct targets and modified bases of RNA cytosine methyltransferases

(2013) Vahid Khoddami et al.   NATURE BIOTECHNOLOGY

Long non-coding RNAs as targets for cytosine methylation

(2013) Thomas Amort et al.   RNA Biology

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

(2013) N. Liu et al.   RNA

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs

(2013) Matthew J. Hangauer et al.   PLoS Genetics

A Small RNA Derived from RNA Coactivator SRA Blocks Steroid Receptor Signaling via Inhibition of Pus1p-Mediated Pseudouridylation of SRA: Evidence of a Novel RNA Binding Domain in the N-Terminus of Steroid Receptors

(2012) Sajal K. Ghosh et al.   BIOCHEMISTRY

Genome-wide analysis of long noncoding RNA stability

(2012) M. B. Clark et al.   GENOME RESEARCH

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

(2012) Zhiyu Peng et al.   NATURE BIOTECHNOLOGY

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

(2012) Jeffrey E. Squires et al.   NUCLEIC ACIDS RESEARCH

The birth of the Epitranscriptome: deciphering the function of RNA modifications

(2012) Yogesh Saletore et al.   GENOME BIOLOGY

Non-coding RNA and antisense RNA. Nature’s trash or treasure?

(2011) Stuart Knowling et al.   BIOCHIMIE

Converting nonsense codons into sense codons by targeted pseudouridylation

(2011) John Karijolich et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization

(2011) M. M. Duszczyk et al.   RNA

Multiple Roles for the Non-Coding RNA SRA in Regulation of Adipogenesis and Insulin Sensitivity

(2010) Bin Xu et al.   PLoS One

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE