Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Cancer statistics, 2020

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Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

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Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

(2019) Giulio Poli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Massively Parallel Implementation of Steered Molecular Dynamics in Tinker-HP: Comparisons of Polarizable and Non-Polarizable Simulations of Realistic Systems

(2019) Frédéric Célerse et al.   Journal of Chemical Theory and Computation

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

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Monoacylglycerol lipase inhibitors: Modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders

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Emerging organoid models: leaping forward in cancer research

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An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy

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Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

(2018) Giulio Poli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2018) Mojgan Aghazadeh Tabrizi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

(2018) Giulia Bononi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

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Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

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Design, synthesis, and evaluation of piperazinyl pyrrolidin-2-ones as a novel series of reversible monoacylglycerol lipase inhibitors

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Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids

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Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase

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Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake

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Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer

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Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

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Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells

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Click Chemistry, A Potent Tool in Medicinal Sciences

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Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

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A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

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Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

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Identification and characterization of a new reversible MAGL inhibitor

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Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain

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Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met-driven Pancreatic Carcinoma

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PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

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Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression

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In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

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STAR: ultrafast universal RNA-seq aligner

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The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors

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Evidence for Bidirectional Endocannabinoid Transport across Cell Membranes

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The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

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Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

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Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

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Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

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Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

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Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

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CAY10499, a Novel Monoglyceride Lipase Inhibitor Evidenced by an Expeditious MGL Assay

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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

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