Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models

LBA54ENTRATA: Randomized, double-blind, phase II study of telaglenastat (tela; CB-839) + everolimus (E) vs placebo (pbo) + E in patients (pts) with advanced/metastatic renal cell carcinoma (mRCC)

(2019) R J Motzer et al.   ANNALS OF ONCOLOGY

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism

(2018) Qingqiu Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab

(2017) Neel Patel et al.   EJNMMI Research

Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

(2016) Christina A. Wicker et al.   BMC GENOMICS

Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses

(2016) Jack Phan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Reirradiation of Head and Neck Cancers With Intensity Modulated Radiation Therapy: Outcomes and Analyses

(2016) Vinita Takiar et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer

(2015) Gissela Borrego-Soto et al.   GENETICS AND MOLECULAR BIOLOGY

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Biological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers

(2014) V. Bol et al.   Biomed Research International

HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity

(2013) Thorsten Rieckmann et al.   RADIOTHERAPY AND ONCOLOGY

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

(2012) Tohru Yamamori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Squamous Cell Carcinomas of the Head and Neck in Fanconi Anemia: Risk, Prevention, Therapy, and the Need for Guidelines

(2012) K. Scheckenbach et al.   KLINISCHE PADIATRIE

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells

(2011) Vlad C. Sandulache et al.   CANCER

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): A comprehensive analysis by tumour site

(2011) Pierre Blanchard et al.   RADIOTHERAPY AND ONCOLOGY

Pattern of Failure after Helical Tomotherapy in Head and Neck Cancer

(2010) Ashraf Farrag et al.   STRAHLENTHERAPIE UND ONKOLOGIE