Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours

Genetic Mechanisms of Immune Evasion in Colorectal Cancer

(2018) Catherine S. Grasso et al.   Cancer Discovery

Rewiring the taste system

(2017) Hojoon Lee et al.   NATURE

β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice

(2017) Dany Gaillard et al.   PLoS Genetics

Initial results from a phase 1a/b study of OMP-131R10, a first-in-class anti-RSPO3 antibody, in advanced solid tumors and previously treated metastatic colorectal cancer (CRC)

(2016) J. Bendell et al.   EUROPEAN JOURNAL OF CANCER

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

(2016) Catherine E. Bond et al.   Oncotarget

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

(2015) A. Holtzhausen et al.   Cancer Immunology Research

A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

(2015) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

(2013) Oksana Voloshanenko et al.   Nature Communications

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Critical aspects of the Bayesian approach to phase I cancer trials

(2008) Beat Neuenschwander et al.   STATISTICS IN MEDICINE