Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics

(2018) Thomas A. Rando et al.   Cell Stem Cell

TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium

(2018) Michele A. Corrigan et al.   Scientific Reports

Ciliotherapy Treatments to Enhance Biochemically- and Biophysically-Induced Mesenchymal Stem Cell Osteogenesis: A Comparison Study

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Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium

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Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study

(2018) Elena Stavenschi et al.   Stem Cell Research & Therapy

Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration

(2017) Elena Stavenschi et al.   JOURNAL OF BIOMECHANICS

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

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Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism

(2016) Julia C. Chen et al.   FASEB JOURNAL

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

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Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood

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Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner

(2016) Marie-Noëlle Labour et al.   Scientific Reports

Ciliary adenylyl cyclases control the Hedgehog pathway

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Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation

(2015) Yu Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors

(2014) Partha Sinha et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes

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The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Mesenchymal Stem Cells in Bone Regeneration

(2013) M. Noelle Knight et al.   Advances in Wound Care

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells

(2012) David A. Hoey et al.   STEM CELLS

Additive Effects of Sonic Hedgehog and Nell-1 Signaling in Osteogenic Versus Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

(2012) Aaron W. James et al.   STEM CELLS AND DEVELOPMENT

Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes

(2011) Yvonne Y. Shao et al.   BONE

Sonic hedgehog enhances the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells

(2011) Jia‑Qin Cai et al.   CELL BIOLOGY INTERNATIONAL

Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

(2011) Joy Y. Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One