A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma

(2019) Jiayi Huang et al.   JOURNAL OF NEURO-ONCOLOGY

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

(2018) Maricela Viola-Rhenals et al.   CURRENT MEDICINAL CHEMISTRY

Incidence and origin of histologically confirmed liver metastases: an explorative case-study of 23,154 patients

(2016) Jannemarie de Ridder et al.   Oncotarget

Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models

(2016) Manman Deng et al.   Oncotarget

Copper improves the anti-angiogenic activity of disulfiram through the EGFR/Src/VEGF pathway in gliomas

(2015) Yi Li et al.   CANCER LETTERS

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

A Phase IIb Trial Assessing the Addition of Disulfiram to Chemotherapy for the Treatment of Metastatic Non-Small Cell Lung Cancer

(2015) H. Nechushtan et al.   ONCOLOGIST

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide

(2015) Joanna Triscott et al.   Oncotarget

Oxidizing to death

(2014) Ansgar Brüning et al.   CELL CYCLE

Cytotoxic effects of pyrrolidine dithiocarbamate in small-cell lung cancer cells, alone and in combination with cisplatin

(2014) SHINICHI TAHATA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells

(2013) Ameya Paranjpe et al.   CARCINOGENESIS

Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer

(2013) M T Schweizer et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells

(2011) Bing Xu et al.   BLOOD CELLS MOLECULES AND DISEASES

Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

(2011) N C Yip et al.   BRITISH JOURNAL OF CANCER

Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives

(2011) Elisa Dalla Pozza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper Binding Agents Acting as Copper Ionophores Lead to Caspase Inhibition and Paraptotic Cell Death in Human Cancer Cells

(2011) Saverio Tardito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma

(2010) Brian W. Morrison et al.   MELANOMA RESEARCH

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

(2010) Jianqing Lin et al.   PROSTATE

Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma

(2009) Christudas Morais et al.   APOPTOSIS

Involvement of activating transcription factors JNK, NF-κB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex

(2008) Sung-Ho Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells

(2008) Boris Cvek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

(2008) Vesna Milacic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis

(2007) Jie Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS