Chronic intermittent hypoxia enhances pathological tau seeding, propagation, and accumulation, and exacerbates Alzheimer’s-like memory and synaptic plasticity deficits and molecular signatures

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

(2020) Lynn van Olst et al.   NEUROBIOLOGY OF AGING

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

(2020) Minghui Wang et al.   NEURON

Obstructive Sleep Apnea and Longitudinal Alzheimer's disease biomarker changes

(2019) Omonigho M Bubu et al.   SLEEP

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

(2019) Renzo Mancuso et al.   BRAIN

Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures

(2019) Abhijeet Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial Morphometric Parameters Correlate With the Expression Level of IL-1β, and Allow Identifying Different Activated Morphotypes

(2019) María del Mar Fernández-Arjona et al.   Frontiers in Cellular Neuroscience

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

(2018) Lynn van Olst et al.   AGING CELL

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

(2018) Thomas E Cope et al.   BRAIN

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach

(2018) Kelly M. Cahill et al.   Scientific Reports

Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice

(2018) Chun-ling Dai et al.   Alzheimers Research & Therapy

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Impaired LTP- but not LTD-Like Cortical Plasticity in Alzheimer's Disease Patients

(2018) Giacomo Koch et al.   JOURNAL OF ALZHEIMERS DISEASE

Imaging the evolution and pathophysiology of Alzheimer disease

(2018) William Jagust   NATURE REVIEWS NEUROSCIENCE

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

(2018) Jack Brelstaff et al.   Cell Reports

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

(2018) Minghui Wang et al.   Scientific Data

Intermittent hypoxia disrupts adult neurogenesis and synaptic plasticity in the dentate gyrus

(2018) Maggie A Khuu et al.   JOURNAL OF NEUROSCIENCE

Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice

(2018) Yan Zhu et al.   JOURNAL OF NEUROSCIENCE

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology

(2018) Carmen Romero-Molina et al.   Frontiers in Cellular Neuroscience

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

(2017) Syed F. Kazim et al.   Frontiers in Aging Neuroscience

Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging

(2017) Sosuke Yagishita et al.   Molecular Brain

Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment

(2017) Yue Leng et al.   JAMA Neurology

Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome

(2017) Syed Faraz Kazim et al.   Scientific Reports

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies

(2016) Victor Anggono et al.   NEURAL PLASTICITY

Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory

(2015) Lin-Hao Xu et al.   ANTIOXIDANTS & REDOX SIGNALING

Associations Between Sleep-Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community-Dwelling Men: The Osteoporotic Fractures in Men Sleep Study

(2015) Terri Blackwell et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Multiscale Embedded Gene Co-expression Network Analysis

(2015) Won-Min Song et al.   PLoS Computational Biology

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

(2015) Tomas Fanutza et al.   eLife

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

(2014) Syed Faraz Kazim et al.   NEUROBIOLOGY OF DISEASE

Vascular Effects of Intermittent Hypoxia

(2013) N. L. Kanagy   ILAR JOURNAL

Cardiovascular Consequences of Sleep-Disordered Breathing: Contribution of Animal Models to Understanding of the Human Disease

(2013) M. Dematteis et al.   ILAR JOURNAL

Hyperexcitability and epileptic seizures in a model of frontotemporal dementia

(2013) Ana M. García-Cabrero et al.   NEUROBIOLOGY OF DISEASE

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

(2011) Diana AT Nijholt et al.   JOURNAL OF PATHOLOGY

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

One-trial object recognition in rats and mice: Methodological and theoretical issues

(2010) A. Ennaceur   BEHAVIOURAL BRAIN RESEARCH

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE