Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages

(2020) Yuqing Gong et al.   Scientific Reports

A TfR-Binding Cystine-Dense Peptide Promotes Blood–Brain Barrier Penetration of Bioactive Molecules

(2020) Zachary R. Crook et al.   JOURNAL OF MOLECULAR BIOLOGY

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Targeting nanoparticles to the brain by exploiting the blood–brain barrier impermeability to selectively label the brain endothelium

(2020) Daniel Gonzalez-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies

(2020) Olivia Osborne et al.   TRENDS IN NEUROSCIENCES

Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes

(2020) Lukas Gleue et al.   Cells

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides

(2019) Keith Henry Moss et al.   MOLECULAR PHARMACEUTICS

Cerebral Vascular Toxicity of Antiretroviral Therapy

(2019) Luc Bertrand et al.   Journal of Neuroimmune Pharmacology

A Novel Transwell Blood Brain Barrier Model Using Primary Human Cells

(2019) Nicole L. Stone et al.   Frontiers in Cellular Neuroscience

Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin‐Mediated Amyloidosis

(2019) Xiaoping Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

(2019) Sounak Bagchi et al.   Drug Design Development and Therapy

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

(2019) Fadwa Odeh et al.   MOLECULES

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Non-Viral Delivery To Enable Genome Editing

(2018) Yuan Rui et al.   TRENDS IN BIOTECHNOLOGY

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Difficulties and flaws in performing accurate determinations of zeta potentials of metal nanoparticles in complex solutions—Four case studies

(2017) Sara Skoglund et al.   PLoS One

Cancer-targeted Nucleic Acid Delivery and Quantum Dot Imaging Using EGF Receptor Aptamer-conjugated Lipid Nanoparticles

(2017) Min Woo Kim et al.   Scientific Reports

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Orthogonal Click Conjugation to the Liposomal Surface Reveals the Stability of the Lipid Anchorage as Crucial for Targeting

(2016) Thomas Fritz et al.   CHEMISTRY-A EUROPEAN JOURNAL

2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors

(2016) Youngju Lee et al.   Nucleic Acid Therapeutics

Cell-Specific RNA Aptamer against Human CCR5 Specifically Targets HIV-1 Susceptible Cells and Inhibits HIV-1 Infectivity

(2015) Jiehua Zhou et al.   CHEMISTRY & BIOLOGY

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

(2015) Chao Liang et al.   NATURE MEDICINE

Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study

(2015) Ole B Suhr et al.   Orphanet Journal of Rare Diseases

Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein

(2015) J. Chen et al.   SCIENCE

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags

(2014) Kerstin Menck et al.   Jove-Journal of Visualized Experiments

Defining the functional determinants for RNA surveillance by RIG-I

(2013) Andrew Kohlway et al.   EMBO REPORTS

A Novel Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein

(2013) Shun-lung Fang et al.   PLoS One

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

(2013) Ravi L Rungta et al.   Molecular Therapy-Nucleic Acids

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine

(2012) Mao Ye et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shuttle-Mediated Nanoparticle Delivery to the Blood-Brain Barrier

(2012) Daniela Guarnieri et al.   Small

A GALA lipopeptide mediates pH- and membrane charge dependent fusion with stable giant unilamellar vesicles

(2012) Thomas P. Etzerodt et al.   Soft Matter

Enhanced Intracellular Delivery and Chemotherapy for Glioma Rats by Transferrin-Conjugated Biodegradable Polymersomes Loaded with Doxorubicin

(2011) Zhiqing Pang et al.   BIOCONJUGATE CHEMISTRY

Brain delivery and cellular internalization mechanisms for transferrin conjugated biodegradable polymersomes

(2011) Zhiqing Pang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery

(2011) Yao Qin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

(2011) Sun-Young Hwang et al.   NUCLEIC ACIDS RESEARCH

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection byCryptococcus neoformans

(2009) Kiem Vu et al.   EUKARYOTIC CELL

Targeting anti-HIV drugs to the CNS

(2009) Kavitha S Rao et al.   Expert Opinion on Drug Delivery

NanoART, neuroAIDS and CNS drug delivery

(2009) Ari Nowacek et al.   Nanomedicine

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH