Cytokines as therapeutic targets for cardio- and cerebrovascular diseases

2019 ATVB Plenary Lecture

(2020) Tian X. Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

(2020) Luca Liberale et al.   EUROPEAN HEART JOURNAL

Interleukin‐1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST‐Segment–Elevation Myocardial Infarction

(2020) Antonio Abbate et al.   Journal of the American Heart Association

Targeting cardiovascular inflammation: next steps in clinical translation

(2020) Patrick R Lawler et al.   EUROPEAN HEART JOURNAL

Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms

(2020) Luca Liberale et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

(2020) Cheng Gao et al.   Nature Communications

Inflammation and cardiovascular diseases: lessons from seminal clinical trials

(2020) Luca Liberale et al.   CARDIOVASCULAR RESEARCH

Postischemic Administration of IL-1α Neutralizing Antibody Reduces Brain Damage and Neurological Deficit in Experimental Stroke

(2020) Luca Liberale et al.   CIRCULATION

Interleukin-1 receptor inhibition reduces stroke size in a murine model of sickle cell disease

(2020) Jessica Venugopal et al.   HAEMATOLOGICA

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines

(2020) Ben Kirk et al.   Current Osteoporosis Reports

Circular RNA circ_0003645 silencing alleviates inflammation and apoptosis via the NF-κB pathway in endothelial cells induced by oxLDL

(2020) Mingming Qin et al.   GENE

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

(2020) Valerio Gelfo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Risk of Cardiovascular Events Associated With Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis

(2020) Gulsen Ozen et al.   JOURNAL OF RHEUMATOLOGY

Functions of the CXCL12 Receptor ACKR3/CXCR7—What Has Been Perceived and What Has Been Overlooked

(2020) Christian Koch et al.   MOLECULAR PHARMACOLOGY

Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure

(2019) Brendan M. Everett et al.   CIRCULATION

Sleep modulates haematopoiesis and protects against atherosclerosis

(2019) Cameron S. McAlpine et al.   NATURE

The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse

(2019) Stefano Toldo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis

(2019) Amélie Vromman et al.   EUROPEAN HEART JOURNAL

Tumour necrosis factor superfamily members in ischaemic vascular diseases

(2019) Megan Nash et al.   CARDIOVASCULAR RESEARCH

Chemokines as Therapeutic Targets in Cardiovascular Disease

(2019) Heidi Noels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cytokine Circuits in Cardiovascular Disease

(2019) Jesse W. Williams et al.   IMMUNITY

Relaxin mitigates microvascular damage and inflammation following cardiac ischemia–reperfusion

(2019) Xiao-Ming Gao et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials

(2019) Borja Ibanez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis

(2019) Gorabi et al.   Biomolecules

Cyclodextrin‐Derived Intrinsically Bioactive Nanoparticles for Treatment of Acute and Chronic Inflammatory Diseases

(2019) Jiawei Guo et al.   ADVANCED MATERIALS

Rapamycin-Loaded Leukosomes Reverse Vascular Inflammation

(2019) Christian Boada et al.   CIRCULATION RESEARCH

Cytokines in Inflammatory Disease

(2019) Shinwan Kany et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke

(2019) Kathleen E. Salmeron et al.   Journal of Neuroinflammation

Interleukin-1β Mediates Arterial Thrombus Formation via NET-Associated Tissue Factor

(2019) Luca Liberale et al.   Journal of Clinical Medicine

Usefulness of Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated C-Reactive Protein

(2018) Cory Trankle et al.   AMERICAN JOURNAL OF CARDIOLOGY

Post-ischaemic administration of the murine Canakinumab-surrogate antibody improves outcome in experimental stroke

(2018) Luca Liberale et al.   EUROPEAN HEART JOURNAL

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases

(2018) Luca Liberale et al.   THROMBOSIS AND HAEMOSTASIS

IL‐23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice

(2018) Daniel Engelbertsen et al.   Journal of the American Heart Association

Inflammation, Autophagy, and Apoptosis After Myocardial Infarction

(2018) Xianwei Wang et al.   Journal of the American Heart Association

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

(2018) Francesca Romana Rizzo et al.   NEURAL PLASTICITY

Atherosclerosis in Rheumatoid Arthritis: Promoters and Opponents

(2018) Federico Carbone et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p–dependent down-regulation of cGMP-dependent kinase 1

(2018) Seunghwan Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor-α in Heart Failure: an Updated Review

(2018) Sarah M. Schumacher et al.   Current Cardiology Reports

An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis

(2018) Aliia R. Fatkhullina et al.   IMMUNITY

Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia–reperfusion injury

(2018) Jinzhou Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Aging: the next cardiovascular disease?

(2017) Giovanni G Camici et al.   EUROPEAN HEART JOURNAL

Reduction of Myocardial Ischemia–Reperfusion Injury by Inhibiting Interleukin-1 Alpha

(2017) Adolfo G. Mauro et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis

(2017) Thomas Mohr et al.   PLoS One

Short-term application of tocilizumab during myocardial infarction (STAT-MI)

(2017) Matthew B. Carroll et al.   RHEUMATOLOGY INTERNATIONAL

Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study

(2017) Kensuke Kume et al.   RHEUMATOLOGY INTERNATIONAL

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Pathophysiological relevance of macrophage subsets in atherogenesis

(2017) Luca Liberale et al.   THROMBOSIS AND HAEMOSTASIS

Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation

(2017) Patricia Ruiz-Limón et al.   Translational Research

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension

(2017) Hai-Jian Sun et al.   Cell Death & Disease

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

(2016) Bettina Hjelm Clausen et al.   ACTA NEUROPATHOLOGICA

Targeting Inflammation in Primary Cardiovascular Prevention

(2016) Federico Carbone et al.   CURRENT PHARMACEUTICAL DESIGN

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial

(2016) Ola Kleveland et al.   EUROPEAN HEART JOURNAL

Reduced acute myocardial ischemia–reperfusion injury in IL-6-deficient mice employing a closed-chest model

(2016) Willeke M. C. Jong et al.   INFLAMMATION RESEARCH

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

(2016) Pernille M Madsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-6 pathway in the liver: From physiopathology to therapy

(2016) Dirk Schmidt-Arras et al.   JOURNAL OF HEPATOLOGY

CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation

(2016) S M Coomes et al.   Mucosal Immunology

Interleukin-1 in Stroke

(2016) Oluwaseun A. Sobowale et al.   STROKE

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

(2016) Xiangrong Liu et al.   STROKE

Vitamin D receptor is expressed within human carotid plaques and correlates with pro-inflammatory M1 macrophages

(2016) Federico Carbone et al.   VASCULAR PHARMACOLOGY

Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion

(2016) Minke H. T. Hartman et al.   PLoS One

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

(2016) Bettina Hjelm Clausen et al.   Scientific Reports

Comparative Safety of Interleukin-1 Blockade With Anakinra in Patients With ST-Segment Elevation Acute Myocardial Infarction (from the VCU-ART and VCU-ART2 Pilot Studies)

(2015) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin

(2015) Chao Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis

(2015) Camille Roubille et al.   ANNALS OF THE RHEUMATIC DISEASES

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

(2015) Samaneh Maysami et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-1alpha induces angiogenesis in brain endothelial cellsin vitro: implications for brain angiogenesis after acute injury

(2015) Kathleen Salmeron et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal self-injury mediated by IL-1β and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia

(2015) Alexandre Savard et al.   Journal of Neuroinflammation

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Tnf-α R1 signaling can rescue functional cortical plasticity impaired in early post-stroke period

(2015) Monika Liguz-Lecznar et al.   NEUROBIOLOGY OF AGING

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

(2015) Jean-Eric Alard et al.   Science Translational Medicine

Versatile functions for IL-6 in metabolism and cancer

(2015) Jan Mauer et al.   TRENDS IN IMMUNOLOGY

Neuroprotective effect of interleukin-6 in a rat model of cerebral ischemia

(2015) QILIN FENG et al.   Experimental and Therapeutic Medicine

Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats

(2015) Naohiro Iwata et al.   Biomed Research International

Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis

(2015) Bartłomiej Kisiel et al.   Journal of Immunology Research

Soluble or soluble/membrane TNF-± inhibitors protect the brain from focal ischemic injury in rats

(2014) C. A. Arango-Dávila et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Interleukin-1β Blockade Improves Left Ventricular Systolic/Diastolic Function and Restores Contractility Reserve in Severe Ischemic Cardiomyopathy in the Mouse

(2014) Stefano Toldo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

(2014) Bettina Hjelm Clausen et al.   Journal of Neuroinflammation

Intracerebral interleukin-10 injection modulates post-ischemic neuroinflammation: An experimental microarray study

(2014) Arthur Liesz et al.   NEUROSCIENCE LETTERS

Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]

(2013) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Coronary aspirate TNFα reflects saphenous vein bypass graft restenosis risk in diabetic patients

(2013) Theodor Baars et al.   Cardiovascular Diabetology

Increased Atherosclerotic Lesion Formation and Vascular Leukocyte Accumulation in Renal Impairment Are Mediated by Interleukin-17A

(2013) Shuwang Ge et al.   CIRCULATION RESEARCH

Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study

(2013) Gareth J Padfield et al.   HEART

Soluble TNF Receptor 1-Secreting ex Vivo-Derived Dendritic Cells Reduce Injury After Stroke

(2013) Melissa G Works et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-10 Deficiency Exacerbates the Brain Inflammatory Response to Permanent Ischemia without Preventing Resolution of the Lesion

(2013) Isabel Pérez-de Puig et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transforming Growth Factor-  Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17-Dependent Pathway

(2013) A. Gistera et al.   Science Translational Medicine

Regenerative Wound Healing: The Role of Interleukin-10

(2013) Alice King et al.   Advances in Wound Care

Essential role of interleukin-6 in post-stroke angiogenesis

(2012) Karen Gertz et al.   BRAIN

Recombinant Human Interleukin-1 Receptor Antagonist Provides Cardioprotection During Myocardial Ischemia Reperfusion in the Mouse

(2012) Stefano Toldo et al.   CARDIOVASCULAR DRUGS AND THERAPY

TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes

(2012) Rebecca Davis et al.   CELL CYCLE

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

(2012) C. Cavelti-Weder et al.   DIABETES CARE

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse

(2012) Stefano Toldo et al.   EXPERIMENTAL PHYSIOLOGY

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation

(2012) Jun-O Jin et al.   JOURNAL OF AUTOIMMUNITY

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Myocardial infarction accelerates atherosclerosis

(2012) Partha Dutta et al.   NATURE

Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial Ischemia/Reperfusion Injury

(2012) Christina Grothusen et al.   TheScientificWorldJOURNAL

Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

(2012) Joachim Pircher et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice

(2011) Keiko Danzaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73

(2011) S Rastogi et al.   CELL DEATH AND DIFFERENTIATION

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

(2011) Matthew R. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1 -Rich Microparticles

(2011) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Lessons from human coronary aspirate

(2011) Petra Kleinbongard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse

(2011) Antonio Abbate et al.   PLoS One

Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice

(2010) Emily Smith et al.   CIRCULATION

Vasoconstrictor Potential of Coronary Aspirate From Patients Undergoing Stenting of Saphenous Vein Aortocoronary Bypass Grafts and Its Pharmacological Attenuation

(2010) Petra Kleinbongard et al.   CIRCULATION RESEARCH

TNFα in myocardial ischemia/reperfusion, remodeling and heart failure

(2010) Petra Kleinbongard et al.   HEART FAILURE REVIEWS

Interleukin-1 Trap Attenuates Cardiac Remodeling After Experimental Acute Myocardial Infarction in Mice

(2010) Benjamin W Van Tassell et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

TNF-α induces matrix metalloproteinase-9 expression in A549 cells: Role of TNFR1/TRAF2/PKCα-dependent signaling pathways

(2010) I-Ta Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

FADD: a regulator of life and death

(2010) Léa Tourneur et al.   TRENDS IN IMMUNOLOGY

Resveratrol Improves Endothelial Function

(2009) Hanrui Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Influence of TNF-α and biomechanical stress on endothelial anti- and prothrombotic genes

(2009) N. Bergh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

(2009) T. van Es et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-1/IL-1ra balance in the brain revisited – Evidence from transgenic mouse models

(2009) S. Spulber et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes

(2009) Wendy L. Thompson et al.   BRAIN RESEARCH

Tumor Necrosis Factor-α and Its Receptors 1 and 2

(2009) Rainer Schulz et al.   CIRCULATION

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

(2009) Tariq Hamid et al.   CIRCULATION

Interleukin-1β promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways

(2009) Jun Hee Lim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

(2009) Katia Boniface et al.   IMMUNOLOGICAL REVIEWS

Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice

(2009) C. Erbel et al.   JOURNAL OF IMMUNOLOGY

In vivoover-expression of interleukin-10 increases resistance to focal brain ischemia in mice

(2009) Fabienne de Bilbao et al.   JOURNAL OF NEUROCHEMISTRY

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

(2009) K. L. Lambertsen et al.   JOURNAL OF NEUROSCIENCE

Tumor necrosis factor-alpha deficiency retards early fatty-streak lesion by influencing the expression of inflammatory factors in apoE-null mice

(2009) Ning Xiao et al.   MOLECULAR GENETICS AND METABOLISM

Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling

(2008) Marcin Bujak et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis

(2008) Amanda C. Doran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis

(2008) Catherine Gebhard et al.   BASIC RESEARCH IN CARDIOLOGY

A Single Intravenous sTNFR-Fc Administration at the Time of Reperfusion Limits Infarct Size—Implications in Reperfusion Strategies in Man

(2008) Marie-Claire Toufektsian et al.   CARDIOVASCULAR DRUGS AND THERAPY

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

Tumor Necrosis Factor-α Downregulates Endothelial Nitric Oxide Synthase mRNA Stability via Translation Elongation Factor 1-α 1

(2008) Guijun Yan et al.   CIRCULATION RESEARCH

Interleukin-10 From Transplanted Bone Marrow Mononuclear Cells Contributes to Cardiac Protection After Myocardial Infarction

(2008) Jana S. Burchfield et al.   CIRCULATION RESEARCH

IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR

(2008) Prasanna Krishnamurthy et al.   CIRCULATION RESEARCH

The role of TNF-α receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning

(2008) Michael P. Flaherty et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha

(2008) M Canault et al.   JOURNAL OF PATHOLOGY