Low LAL (Lysosomal Acid Lipase) Expression by Smooth Muscle Cells Relative to Macrophages as a Mechanism for Arterial Foam Cell Formation

Pathways of smooth muscle foam cell formation in atherosclerosis

(2019) Collin S. Pryma et al.   CURRENT OPINION IN LIPIDOLOGY

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis

(2019) Ying Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In VivoHighlights

(2018) Kristin L. Bowden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Survival in infants treated with sebelipase Alfa for lysosomal acid lipase deficiency: an open-label, multicenter, dose-escalation study

(2017) Simon A. Jones et al.   Orphanet Journal of Rare Diseases

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency

(2015) Barbara K. Burton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

Detection of histone modifications at specific gene loci in single cells in histological sections

(2013) Delphine Gomez et al.   NATURE METHODS

Synthetic Cationic Peptide IDR-1018 Modulates Human Macrophage Differentiation

(2013) Olga M. Pena et al.   PLoS One

A New Approach for the Study of Lung Smooth Muscle Phenotypes and Its Application in a Murine Model of Allergic Airway Inflammation

(2013) Jesus Paez-Cortez et al.   PLoS One

Suppression of Autophagic Flux by Bile Acids in Hepatocytes

(2013) Sharon Manley et al.   TOXICOLOGICAL SCIENCES

Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: Not all roads lead to Rome

(2012) Parveer S. Pannu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling

(2012) L. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease

(2011) Philipp S. Wild et al.   Circulation-Cardiovascular Genetics

Lysosomal Acid Lipase Deficiency Impairs Regulation ofABCA1Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage Disease

(2011) Kristin L. Bowden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall

(2009) Maria G. Frid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ATP-Binding Cassette Transporter A1 Expression and Apolipoprotein A-I Binding Are Impaired in Intima-Type Arterial Smooth Muscle Cells

(2009) Hong Y. Choi et al.   CIRCULATION

Oxidized low density lipoprotein-induced transdifferentiation of bone marrow-derived smooth muscle-like cells into foam-like cellsin vitro

(2009) Jun Yu et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans

(2008) Y. Nakashima et al.   CARDIOVASCULAR RESEARCH

Lysosomal Cholesterol Accumulation Inhibits Subsequent Hydrolysis of Lipoprotein Cholesteryl Ester

(2008) W. Gray Jerome et al.   MICROSCOPY AND MICROANALYSIS