Design, synthesis, and molecular docking studies of thiazolidinediones as PPAR‐γ agonists and thymidylate synthase inhibitors

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation

(2020) Neha Upadhyay et al.   BIOORGANIC CHEMISTRY

Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells

(2020) Kalpana Tilekar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Benzylidene thiazolidinediones: Synthesis, in vitro investigations of antiproliferative mechanisms and in vivo efficacy determination in combination with Imatinib

(2020) Hardik Joshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

(2019) Cecilia Pozzi et al.   MOLECULES

Nucleoside dimers analogues with a 1,2,3-triazole linkage: conjugation of floxuridine and thymidine provides novel tools for cancer treatment. Part II

(2019) Dagmara Baraniak et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Thiazolidinediones: the Forgotten Diabetes Medications

(2019) Harold E. Lebovitz   Current Diabetes Reports

Discovery of 5-naphthylidene-2,4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines

(2019) Kalpana Tilekar et al.   BIOORGANIC CHEMISTRY

Synthesis and Antimicrobial Activity of a New Series of Thiazolidine-2,4-diones Carboxamide and Amino Acid Derivatives

(2019) Rakia Abd Alhameed et al.   MOLECULES

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

5-Ene-4-thiazolidinones – An efficient tool in medicinal chemistry

(2017) Danylo Kaminskyy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 2,4- thiazolidinediones: Synthesis, in vitro cytotoxic activity, and mechanistic investigation

(2017) Kamel Metwally et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ)

(2017) Konrad A. Szychowski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments with rhodanine as a scaffold for drug discovery

(2017) Danylo Kaminskyy et al.   Expert Opinion on Drug Discovery

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Synthesis of Some 1,4,6-Trisubstituted-2-oxo-1,2-dihydropyridine-3-carbonitriles and Their Biological Evaluation as Cytotoxic and Antimicrobial Agents

(2015) Hassan M. Faidallah et al.   ARCHIV DER PHARMAZIE

Design, Synthesis, and Biological Evaluation of Thiazolidine-2,4-dione Conjugates as PPAR-γ Agonists

(2015) Syed Nazreen et al.   ARCHIV DER PHARMAZIE

Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression

(2014) Syed Nazreen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists

(2014) Syed Nazreen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efatutazone, an Oral PPAR-γ Agonist, in Combination With Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial

(2013) R. C. Smallridge et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization

(2011) Kai Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Some Novel Fused Pyrazolopyrimidines as Potential Anticancer and Antimicrobial Agents

(2010) Heba A. Abd El Razik et al.   ARCHIV DER PHARMAZIE

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

(2010) Steven D. Knight et al.   ACS Medicinal Chemistry Letters

Anti-tumour activity of CS-7017, a selective peroxisome proliferator-activated receptor gamma agonist of thiazolidinedione class, in human tumour xenografts and a syngeneic tumour implant model

(2008) Naomi Shimazaki et al.   EUROPEAN JOURNAL OF CANCER