Prodrug Activation by Gold Artificial Metalloenzyme‐Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination

Systematic engineering of artificial metalloenzymes for new-to-nature reactions

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Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells

(2020) Junfeng Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy

(2020) Kenward Vong et al.   Small

Gold compounds for catalysis and metal-mediated transformations in biological systems

(2020) Sophie R. Thomas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Platinum-triggered Bond-cleavage of Pentynoyl amide and N-propargyl handles for Drug-Activation

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Polymer-Based Bioorthogonal Nanocatalyst for the Treatment of Bacterial Biofilms

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Recent Progress in N-Heterocyclic Carbene Gold-Catalyzed Reactions of Alkynes Involving Oxidation/Amination/Cycloaddition

(2020) Xiang-Ting Tang et al.   Catalysts

Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

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Transition metal catalysts for the bioorthogonal synthesis of bioactive agents

(2020) Melissa O.N. van de L'Isle et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Polymeric “Clickase” Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells

(2019) Junfeng Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic Relationships and Total Syntheses of Naturally Occurring Benzo[ c ]Phenanthridine Alkaloids

(2019) Vishnumaya Bisai et al.   Asian Journal of Organic Chemistry

Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes

(2019) Shohei Eda et al.   Nature Catalysis

Prodrugs as drug delivery system in oncology

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“Close-to-Release”: Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis

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Bio-additive-based screening: toward evaluation of the biocompatibility of chemical reactions

(2019) Lea Anhäuser et al.   Nature Protocols

Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

(2019) María Sancho-Albero et al.   Nature Catalysis

Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review

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Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications

(2019) Xin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves

(2019) Kenward Vong et al.   Nature Communications

Designed transition metal catalysts for intracellular organic synthesis

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Organometallic catalysis in biological media and living settings

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Glutathione system in animal model of solid tumors: From regulation to therapeutic target

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In vivo catalyzed new-to-nature reactions

(2018) Johannes G Rebelein et al.   CURRENT OPINION IN BIOTECHNOLOGY

Receptor-Based Artificial Metalloenzymes on Living Human Cells

(2018) Wadih Ghattas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy

(2018) Bingjun Sun et al.   NANO LETTERS

Evolving artificial metalloenzymes via random mutagenesis

(2018) Hao Yang et al.   Nature Chemistry

Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism

(2018) Markus Jeschek et al.   TRENDS IN BIOTECHNOLOGY

Bright insights into Palladium-triggered local chemotherapy

(2018) Thomas L Bray et al.   Chemical Science

E. coli surface display of streptavidin for directed evolution of an allylic deallylase

(2018) Tillmann Heinisch et al.   Chemical Science

Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells

(2018) Cristian Vidal et al.   Nature Communications

Intracellular Deprotection Reactions Mediated by Palladium Complexes Equipped with Designed Phosphine Ligands

(2018) Miguel Martínez-Calvo et al.   ACS Catalysis

A Whole Cell E. coli Display Platform for Artificial Metalloenzymes: Poly(phenylacetylene) Production with a Rhodium–Nitrobindin Metalloprotein

(2018) Alexander R. Grimm et al.   ACS Catalysis

An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin

(2018) Jingming Zhao et al.   Catalysis Science & Technology

Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium-Functionalized Microdevices

(2018) Catherine Adam et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle

(2018) Junfeng Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

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Anti-cancer Nitrogen-Containing Heterocyclic Compounds

(2018) Zahra Hosseinzadeh et al.   CURRENT ORGANIC CHEMISTRY

Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli’s Periplasm

(2018) Jingming Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prodrug approach: An overview of recent cases

(2017) Valentina Abet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hydrazone linkages in pH responsive drug delivery systems

(2017) Sandeep J. Sonawane et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nano-palladium is a cellular catalyst for in vivo chemistry

(2017) Miles A. Miller et al.   Nature Communications

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

(2017) Fei-Fei An et al.   Theranostics

Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor

(2016) Belén Rubio-Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

Transition metal catalysis in the mitochondria of living cells

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Chemophototherapy: An Emerging Treatment Option for Solid Tumors

(2016) Dandan Luo et al.   Advanced Science

Ring-Closing and Cross-Metathesis with Artificial Metalloenzymes Created by Covalent Active Site-Directed Hybridization of a Lipase

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Approaches to the design of catalytic metallodrugs

(2015) Joan J Soldevila-Barreda et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation

(2015) Poonam Srivastava et al.   Nature Communications

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

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Come-back of phenanthridine and phenanthridinium derivatives in the 21st century

(2014) Lidija-Marija Tumir et al.   Beilstein Journal of Organic Chemistry

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

Metal-catalyzed uncaging of DNA-binding agents in living cells

(2014) Mateo I. Sánchez et al.   Chemical Science

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

(2014) Jason T. Weiss et al.   Nature Communications

A General Method for Artificial Metalloenzyme Formation through Strain-Promoted Azide-Alkyne Cycloaddition

(2013) Hao Yang et al.   CHEMBIOCHEM

Catalytic Azide Reduction in Biological Environments

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Photoreductive Uncaging of Fluorophore in Response to Protein Oligomers by Templated Reaction in Vitro and in Cellulo

(2012) Kalyan K. Sadhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

(2012) V. Köhler et al.   Nature Chemistry

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

An artificial metalloenzyme for olefin metathesis

(2011) Clemens Mayer et al.   CHEMICAL COMMUNICATIONS

A novel fluorescent probe for Au(iii)/Au(i) ions based on an intramolecular hydroamination of a Bodipy derivative and its application to bioimaging

(2011) Jian-Bo Wang et al.   CHEMICAL COMMUNICATIONS

Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

(2011) Takashi Matsuo et al.   CHEMICAL COMMUNICATIONS

Gold compounds as therapeutic agents for human diseases

(2011) Susan J. Berners-Price et al.   Metallomics

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Prodrugs--from Serendipity to Rational Design

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