A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

(2020) Jamie E. Craig et al.   NATURE GENETICS

The GWAS Diversity Monitor tracks diversity by disease in real time

(2020) Melinda C. Mills et al.   NATURE GENETICS

Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets

(2020) Sheng Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evaluating and improving heritability models using summary statistics

(2020) Doug Speed et al.   NATURE GENETICS

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives

(2020) Buu Truong et al.   Nature Communications

The road ahead in genetics and genomics

(2020) Amy L. McGuire et al.   NATURE REVIEWS GENETICS

A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies

(2020) Xingjie Shi et al.   NUCLEIC ACIDS RESEARCH

A fast and scalable framework for large-scale and ultrahigh-dimensional sparse regression with application to the UK Biobank

(2020) Junyang Qian et al.   PLoS Genetics

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements

(2020) Tiffany Amariuta et al.   NATURE GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Genetic correlations of polygenic disease traits: from theory to practice

(2019) Wouter van Rheenen et al.   NATURE REVIEWS GENETICS

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

(2019) Roseann E. Peterson et al.   CELL

Comparative genetic architectures of schizophrenia in East Asian and European populations

(2019) Max Lam et al.   NATURE GENETICS

Characterizing rare and low-frequency height-associated variants in the Japanese population

(2019) Masato Akiyama et al.   Nature Communications

Improved polygenic prediction by Bayesian multiple regression on summary statistics

(2019) Luke R. Lloyd-Jones et al.   Nature Communications

LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations

(2019) Jingsi Ming et al.   BIOINFORMATICS

Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics

(2018) Omer Weissbrod et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LSMM: a statistical approach to integrating functional annotations with genome-wide association studies

(2018) Jingsi Ming et al.   BIOINFORMATICS

A scalable estimator of SNP heritability for biobank-scale data

(2018) Yue Wu et al.   BIOINFORMATICS

Signatures of negative selection in the genetic architecture of human complex traits

(2018) Jian Zeng et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Improving genetic prediction by leveraging genetic correlations among human diseases and traits

(2018) Robert M. Maier et al.   Nature Communications

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History

(2018) Siyang Liu et al.   CELL

Polygenic scores via penalized regression on summary statistics

(2017) Timothy Shin Heng Mak et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

Reevaluation of SNP heritability in complex human traits

(2017) Doug Speed et al.   NATURE GENETICS

Leveraging functional annotations in genetic risk prediction for human complex diseases

(2017) Yiming Hu et al.   PLoS Computational Biology

Estimation of genomic prediction accuracy from reference populations with varying degrees of relationship

(2017) S. Hong Lee et al.   PLoS One

Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611

(2017) Xiaotian Yao et al.   Scientific Reports

On high-dimensional misspecified mixed model analysis in genome-wide association study

(2016) Jiming Jiang et al.   ANNALS OF STATISTICS

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

Genetic identification of familial hypercholesterolemia within a single U.S. health care system

(2016) Noura S. Abul-Husn et al.   SCIENCE

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2015) Robert Maier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

(2014) Joseph K. Pickrell   AMERICAN JOURNAL OF HUMAN GENETICS

minimac2: faster genotype imputation

(2014) Christian Fuchsberger et al.   BIOINFORMATICS

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants

(2013) Li Yang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Improving genetic risk prediction by leveraging pleiotropy

(2013) Cong Li et al.   HUMAN GENETICS

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panels

(2012) M. Erbe et al.   JOURNAL OF DAIRY SCIENCE

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

(2012) Michael C Turchin et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Improved whole-chromosome phasing for disease and population genetic studies

(2012) Olivier Delaneau et al.   NATURE METHODS

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Extension of the bayesian alphabet for genomic selection

(2011) David Habier et al.   BMC BIOINFORMATICS

Genomics for the world

(2011) Carlos D. Bustamante et al.   NATURE

BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies

(2010) Xiang Wan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups

(2010) Kevin M. Waters et al.   PLoS Genetics

Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies

(2009) Shuhua Xu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation

(2009) Jieming Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Genetic Structure of Europeans: A View from the North–East

(2009) Mari Nelis et al.   PLoS One

Next generation disparities in human genomics: concerns and remedies

(2009) Anna C. Need et al.   TRENDS IN GENETICS

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics