Rhodium-Catalyzed C–H Alkenylation/Electrocyclization Cascade Provides Dihydropyridines That Serve as Versatile Intermediates to Diverse Nitrogen Heterocycles

Highly Diastereoselective Functionalization of Piperidines by Photoredox-Catalyzed α-Amino C–H Arylation and Epimerization

(2020) Morgan M. Walker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation of Aminocyclopentadienes from Silyldihydropyridines: Ring Contractions Driven by Anion Stabilization

(2018) Morgan M. Walker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis

(2018) Joshua B. McManus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields

(2018) Didier F. Vargas et al.   NATURAL PRODUCT REPORTS

Expanding the medicinal chemistry synthetic toolbox

(2018) Jonas Boström et al.   NATURE REVIEWS DRUG DISCOVERY

π-Facial Selectivities in Hydride Reductions of Hindered Endocyclic Iminium Ions

(2018) Shuming Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks

(2016) Shuming Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis ofent-Ketorfanol via a C-H Alkenylation/Torquoselective 6π Electrocyclization Cascade

(2015) Eric M. Phillips et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Diastereoselective Synthesis of Highly Substituted, Oxygenated Piperidines from Tetrahydropyridines

(2015) Shuming Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Expedient Access to 2,3-Dihydropyridines from Unsaturated Oximes by Rh(III)-Catalyzed C–H Activation

(2015) Fedor Romanov-Michailidis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C–H Activation Made Simple

(2015) Brendan J. Fallon et al.   ACS Catalysis

Regio- and Stereoselective 1,2-Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers

(2014) Simon Duttwyler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C–H Functionalization Sequence

(2014) Tehetena Mesganaw et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C–H Functionalization Sequences

(2014) Tehetena Mesganaw et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Unstabilized Azomethine Ylides for the Stereoselective Synthesis of Substituted Piperidines, Tropanes, and Azabicyclo[3.1.0] Systems

(2013) Michael A. Ischay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Isoquinuclidines from Highly Substituted Dihydropyridines via the Diels–Alder Reaction

(2013) Rhia M. Martin et al.   ORGANIC LETTERS

Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis

(2013) S. Duttwyler et al.   SCIENCE

Developments in the Synthesis of 1,2-Dihydropyridines

(2013) Artur Silva et al.   SYNTHESIS-STUTTGART

Torsional control of stereoselectivities in electrophilic additions and cycloadditions to alkenes

(2013) Hao Wang et al.   Chemical Science

Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines

(2012) James A. Bull et al.   CHEMICAL REVIEWS

Synthesis of Pyridines from Ketoximes and Terminal Alkynes via C–H Bond Functionalization

(2012) Rhia M. Martin et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Diastereoselective Synthesis of Tetrahydropyridines by a C–H Activation–Cyclization–Reduction Cascade

(2012) Simon Duttwyler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible light-induced intramolecular cyclization reactions of diamines: a new strategy to construct tetrahydroimidazoles

(2011) Jun Xuan et al.   CHEMICAL COMMUNICATIONS

Synthesis of Cyclic Enones via Direct Palladium-Catalyzed Aerobic Dehydrogenation of Ketones

(2011) Tianning Diao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of an  -Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity

(2011) A. McNally et al.   SCIENCE

Highly Diastereoselective Synthesis of Substituted Pyrrolidines Using a Sequence of Azomethine Ylide Cycloaddition and Nucleophilic Cyclization

(2010) Guillaume Bélanger et al.   ORGANIC LETTERS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Dihydropyridines and Pyridines from Imines and Alkynes via C−H Activation

(2008) Denise A. Colby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthetic Access to the Hetisine Alkaloids: Total Synthesis of (+)-Nominine

(2007) Kevin M. Peese et al.   CHEMISTRY-A EUROPEAN JOURNAL

Indolizidine and quinolizidine alkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS

Rhodium-Catalyzed One-Pot Synthesis of Substituted Pyridine Derivatives from α,β-Unsaturated Ketoximes and Alkynes

(2007) Kanniyappan Parthasarathy et al.   ORGANIC LETTERS