Regio- and Stereoselective 1,2-Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers

Catalytic Asymmetric Five-Component Tandem Reaction: Diastereo- and Enantioselective Synthesis of Densely Functionalized Tetrahydropyridines with Biological Importance

(2013) Feng Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Nickel-Catalyzed Enantioselective Arylation of Pyridinium Ions: Harnessing an Iminium Ion Activation Mode

(2013) Stephen T. Chau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Catalytic Asymmetric Synthesis of Polysubstituted Piperidines Using a Rhodium(I)-Catalyzed [2+2+2] Cycloaddition Employing a Cleavable Tether

(2013) Timothy J. Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

(2013) Xuejian Li et al.   CHEMICAL COMMUNICATIONS

Addition of Organometallic Reagents to ChiralN-Methoxylactams: Enantioselective Syntheses of Pyrrolidines and Piperidines

(2013) Mascha Jäkel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Rhodium-Catalyzed [2+2+2] Cycloaddition of Diynes to Sulfonimines

(2013) Muriel Amatore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unstabilized Azomethine Ylides for the Stereoselective Synthesis of Substituted Piperidines, Tropanes, and Azabicyclo[3.1.0] Systems

(2013) Michael A. Ischay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids

(2013) Haruki Mizoguchi et al.   Nature Chemistry

Synthesis of Quaternary α-Methyl α-Amino Acids by Asymmetric Alkylation of Pseudoephenamine Alaninamide Pivaldimine

(2013) Cedric L. Hugelshofer et al.   ORGANIC LETTERS

Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis

(2013) S. Duttwyler et al.   SCIENCE

Developments in the Synthesis of 1,2-Dihydropyridines

(2013) Artur Silva et al.   SYNTHESIS-STUTTGART

Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines

(2012) James A. Bull et al.   CHEMICAL REVIEWS

Grob Fragmentation of 2-Azabicyclo[2.2.2]oct-7-ene: Tool for the Stereoselective Synthesis of Polysubstituted Piperidines

(2012) Gérald Lemonnier et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis of 1,2-Dihydropyridines by Rhodium-Catalyzed Hydroboration of Pyridines

(2012) Kazuyuki Oshima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Alkaloid (−)-205B via Stereoselective Reductive Cross-Coupling and Intramolecular [3+2] Cycloaddition

(2012) Dexi Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Diastereoselective Synthesis of Tetrahydropyridines by a C–H Activation–Cyclization–Reduction Cascade

(2012) Simon Duttwyler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Annulation of α,β-Unsaturated Imines and Alkynes via Cobalt-Catalyzed Olefinic C–H Activation

(2012) Takeshi Yamakawa et al.   ORGANIC LETTERS

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rhodium-Catalyzed Enantioselective Addition of Boronic Acids toN-Benzylnicotinate Salts

(2011) Nadeau Christian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[4 + 2] Cyclocondensation Reactions of Tungsten–Dihydropyridine Complexes and the Generation of Tri- and Tetrasubstituted Piperidines

(2011) Daniel P. Harrison et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Enantiopure Substituted Piperidinesviaan Aziridinium Ring Expansion

(2011) Scott B. D. Jarvis et al.   ORGANIC LETTERS

Exploring a Unique Reactivity of 6π-Azaelectrocyclization to Enzyme Inhibition, Natural Products Synthesis, and Molecular Imaging: An Approach to Chemical Biology by Synthetic Chemists

(2011) Katsunori Tanaka et al.   SYNLETT

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Dihydropyridines and Pyridines from Imines and Alkynes via C−H Activation

(2008) Denise A. Colby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indolizidine and quinolizidine alkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS