A Two-Pore Physiologically Based Pharmacokinetic Model to Predict Subcutaneously Administered Different-Size Antibody/Antibody Fragments

Predicting monoclonal antibody pharmacokinetics following subcutaneous administration via whole-body physiologically-based modeling

(2020) Shihao Hu et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Two-pore physiologically based pharmacokinetic model with de novo derived parameters for predicting plasma PK of different size protein therapeutics

(2019) Zhe Li et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats

(2019) Armin Sepp et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Effect of Size on Solid Tumor Disposition of Protein Therapeutics

(2019) Zhe Li et al.   DRUG METABOLISM AND DISPOSITION

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice

(2018) Wolfgang F. Richter et al.   mAbs

Subcutaneous delivery of monoclonal antibodies: How do we get there?

(2018) Margarida Viola et al.   JOURNAL OF CONTROLLED RELEASE

A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

(2015) Katherine L. Gill et al.   AAPS Journal

Development of a physiologically based pharmacokinetic model for a domain antibody in mice using the two-pore theory

(2015) Armin Sepp et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration

(2014) Anas M. Fathallah et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Comparative Physiology of Mice and Rats: Radiometric Measurement of Vascular Parameters in Rodent Tissues

(2014) C. Andrew Boswell et al.   MOLECULAR PHARMACEUTICS

The Antibody Drug Absorption Following Subcutaneous or Intramuscular Administration and Its Mathematical Description by Coupling Physiologically Based Absorption Process with the Conventional Compartment Pharmacokinetic Model

(2013) Liang Zhao et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin

(2012) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

Subcutaneous bioavailability of therapeutic antibodies as a function 
of FcRn binding affinity in mice

(2012) Rong Deng et al.   mAbs

Fluorescence Imaging of the Lymph Node Uptake of Proteins in Mice after Subcutaneous Injection: Molecular Weight Dependence

(2012) Fang Wu et al.   PHARMACEUTICAL RESEARCH

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Properties of the Glomerular Barrier and Mechanisms of Proteinuria

(2008) Börje Haraldsson et al.   PHYSIOLOGICAL REVIEWS