A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

Title
A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins
Authors
Keywords
PBPK, pharmacokinetics, simulation, subcutaneous absorption, therapeutic protein
Journal
AAPS Journal
Volume 18, Issue 1, Pages 156-170
Publisher
American Association of Pharmaceutical Scientists (AAPS)
Online
2015-09-26
DOI
10.1208/s12248-015-9819-4

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