Insulin signaling mediates neurodegeneration in glioma

Circuit dysfunction in SOD1-ALS model first detected in sensory feedback prior to motor neuron degeneration is alleviated by BMP signaling

(2019) Aaron Held et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Dysfunction in Neural Injury

(2019) Xiu-Yun Zhao et al.   Frontiers in Neuroscience

Surveillance and transportation of mitochondria in neurons

(2019) Roeland Vanhauwaert et al.   CURRENT OPINION IN NEUROBIOLOGY

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

(2019) Marta Portela et al.   PLOS BIOLOGY

Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner

(2018) Yoshihiro Miyazono et al.   Scientific Reports

The miR-200 family: multiple effects on gliomas

(2018) Lilei Peng et al.   Cancer Management and Research

Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking

(2018) Marta Portela et al.   GLIA

Aberrant Wnt signaling: a special focus in CNS diseases

(2017) Mercedes Arnés et al.   JOURNAL OF NEUROGENETICS

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

(2017) Yi-Lan Weng et al.   NEURON

The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila

(2017) Sheila Jordán-Álvarez et al.   PLoS One

PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

(2017) Shira Knafo et al.   TRENDS IN NEUROSCIENCES

Drosophilaenhancer-Gal4 lines show ectopic expression during development

(2017) Sergio Casas-Tintó et al.   Royal Society Open Science

Synaptic pathology: A shared mechanism in neurological disease

(2016) Christopher M. Henstridge et al.   AGEING RESEARCH REVIEWS

Mechanisms of metabolic dysfunction in cancer-associated cachexia

(2016) Michele Petruzzelli et al.   GENES & DEVELOPMENT

Cognitive Rehabilitation in Patients with Gliomas and Other Brain Tumors: State of the Art

(2016) E. Bergo et al.   Biomed Research International

Modeling of Mitochondrial Donut Formation

(2015) Qi Long et al.   BIOPHYSICAL JOURNAL

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

(2015) Chantelle F. Sephton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

(2015) Alejandra Figueroa-Clarevega et al.   DEVELOPMENTAL CELL

Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2

(2015) Young Kwon et al.   DEVELOPMENTAL CELL

Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide

(2015) Khaled Messaoudi et al.   DRUG DISCOVERY TODAY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

(2015) Sonal Nagarkar-Jaiswal et al.   eLife

Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways

(2015) Tania A. Jones et al.   Acta Neuropathologica Communications

Emotional and Behavioral Symptoms in Neurodegenerative Disease: A Model for Studying the Neural Bases of Psychopathology

(2014) Robert W. Levenson et al.   Annual Review of Clinical Psychology

Decreased expression of microRNA-200b is an independent unfavorable prognostic factor for glioma patients

(2014) Donghai Men et al.   Cancer Epidemiology

miR-8 controls synapse structure by repression of the actin regulator Enabled

(2014) Carlos M. Loya et al.   DEVELOPMENT

MicroRNA miR-8 regulates multiple growth factor hormones produced fromDrosophilafat cells

(2014) G. J. Lee et al.   INSECT MOLECULAR BIOLOGY

The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner

(2014) Diego Galagovsky et al.   MOLECULAR BIOLOGY OF THE CELL

Beating the odds: extreme long-term survival with glioblastoma

(2014) W. L. Bi et al.   NEURO-ONCOLOGY

STarMir: a web server for prediction of microRNA binding sites

(2014) William Rennie et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development

(2014) C. S. Lu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition

(2013) Javier Morante et al.   DEVELOPMENTAL CELL

Neurocognitive deficits following primary brain tumor treatment: systematic review of a decade of comparative studies

(2013) Amanda K. Gehrke et al.   JOURNAL OF NEURO-ONCOLOGY

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

(2013) Renee D. Read et al.   PLoS Genetics

Cross-talk between Insulin and Wnt Signaling in Preadipocytes

(2012) Jane Palsgaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

The MicroRNAmiR-8is a positive regulator of pigmentation and eclosion inDrosophila

(2011) Jennifer A. Kennell et al.   DEVELOPMENTAL DYNAMICS

Drosophila melanogaster as a model system for human brain cancers

(2011) Renee D. Read   GLIA

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems

(2010) H. Herranz et al.   GENES & DEVELOPMENT

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

Cross Talk between the Insulin and Wnt Signaling Pathways: Evidence from Intestinal Endocrine L Cells

(2008) Fenghua Yi et al.   ENDOCRINOLOGY

Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-β signaling

(2008) A Pen et al.   ONCOGENE