Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration
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Title
Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration
Authors
Keywords
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Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 309, Issue 7, Pages E632-E639
Publisher
American Physiological Society
Online
2015-08-12
DOI
10.1152/ajpendo.00154.2015
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Note: Only part of the references are listed.- Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
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- (2013) A. Kiyosue et al. DIABETES OBESITY & METABOLISM
- Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin
- (2013) J. P. H. Wilding et al. DIABETES OBESITY & METABOLISM
- Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells
- (2013) Yoon Sin Oh et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Treatment with exendin-4 improves the antidiabetic efficacy and reverses hepatic steatosis in glucokinase activator treated db/db mice
- (2013) Nirav Dhanesha et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2013) Pierre Maechler MOLECULAR AND CELLULAR ENDOCRINOLOGY
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- (2012) Itzhak Nissim et al. BIOCHEMICAL JOURNAL
- Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans
- (2012) Frédéric De Ceuninck et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat
- (2012) M. Futamura et al. DIABETOLOGIA
- Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration
- (2012) L. P. Roma et al. DIABETOLOGIA
- The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions
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- Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes
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- Identification of the Mechanism of Action of a Glucokinase Activator From Oral Glucose Tolerance Test Data in Type 2 Diabetic Patients Based on an Integrated Glucose-Insulin Model
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- Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes
- (2009) J. C. Jonas et al. DIABETES OBESITY & METABOLISM
- Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations
- (2009) M. Bensellam et al. DIABETOLOGIA
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- (2009) P. Wei et al. DIABETOLOGIA
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- (2008) J. Chen et al. DIABETES
- Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass
- (2008) Akinobu Nakamura et al. ENDOCRINOLOGY
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