2020 FDA TIDES (Peptides and Oligonucleotides) Harvest

Lumasiran: First Approval

(2021) Lesley J. Scott et al.   DRUGS

The Pharmaceutical Industry in 2020. An Analysis of FDA Drug Approvals from the Perspective of Molecules

(2021) Beatriz G. de la Torre et al.   MOLECULES

2020 FDA drug approvals

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

(2021) Kris M. White et al.   SCIENCE

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

(2020) D.J. Brayden et al.   ADVANCED DRUG DELIVERY REVIEWS

Optimization of antisense-mediated exon skipping for Duchenne muscular dystrophy

(2020) Kasia Dzierlega et al.   GENE THERAPY

Effect of setmelanotide, a melanocortin‐4 receptor agonist, on obesity in Bardet‐Biedl syndrome

(2020) Robert Haws et al.   DIABETES OBESITY & METABOLISM

Viltolarsen: First Approval

(2020) Sohita Dhillon   DRUGS

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

(2020) Alexandre J. Debacker et al.   MOLECULAR THERAPY

Repurposing anticancer drugs for the management of COVID-19

(2020) Khalid El Bairi et al.   EUROPEAN JOURNAL OF CANCER

Antibody–Drug Conjugates: The Last Decade

(2020) Nicolas Joubert et al.   Pharmaceuticals

An overview of process development for antibody-drug conjugates produced by chemical conjugation technology

(2020) Yutaka Matsuda et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Novel Auristatins with High Bystander and Cytotoxic Activities in Drug-Efflux Positive Tumor Models

(2020) Philip N. Moquist et al.   MOLECULAR CANCER THERAPEUTICS

EMA Review of Belantamab Mafodotin (Blenrep) for the Treatment of Adult Patients with Relapsed/Refractory Multiple Myeloma

(2020) Kyriaki Tzogani et al.   ONCOLOGIST

Viltolarsen in Japanese Duchenne muscular dystrophy patients: A phase 1/2 study

(2020) Hirofumi Komaki et al.   Annals of Clinical and Translational Neurology

Current and emerging therapies for Duchenne muscular dystrophy and spinal muscular atrophy

(2020) Mohsan Iftikhar et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacokinetic and Metabolism Studies of Monomethyl Auristatin F via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

(2019) Park et al.   MOLECULES

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

(2018) Kristin L Ayers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

(2018) Karine Clément et al.   NATURE MEDICINE

Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach

(2018) Bethany A. Falls et al.   ACS Chemical Neuroscience

Copper-64: a real theranostic agent

(2018) Bianca Gutfilen et al.   Drug Design Development and Therapy

Molecular basis of primary hyperoxaluria: clues to innovative treatments

(2018) Mirco Dindo et al.   Urolithiasis

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

(2017) Tinh-Hai Collet et al.   Molecular Metabolism

Head-to-Head Comparison of 64 Cu-DOTATATE and 68 Ga-DOTATOC PET/CT: A Prospective Study of 59 Patients with Neuroendocrine Tumors

(2016) Camilla B. Johnbeck et al.   JOURNAL OF NUCLEAR MEDICINE

An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria

(2016) Abigail Liebow et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

(2016) Peter Kühnen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pilot Comparison of 68Ga-RM2 PET and 68Ga-PSMA-11 PET in Patients with Biochemically Recurrent Prostate Cancer

(2015) R. Minamimoto et al.   JOURNAL OF NUCLEAR MEDICINE

Current ADC Linker Chemistry

(2015) Nareshkumar Jain et al.   PHARMACEUTICAL RESEARCH

Antibody–drug conjugates—A new wave of cancer drugs

(2014) Hervé Bouchard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cardiac Hypoxia Imaging: Second-Generation Analogues of 64Cu-ATSM

(2014) M. G. Handley et al.   JOURNAL OF NUCLEAR MEDICINE

Usefulness of 64Cu-ATSM in Head and Neck Cancer

(2013) Ilaria Grassi et al.   CLINICAL NUCLEAR MEDICINE

Primary Hyperoxaluria

(2013) Pierre Cochat et al.   NEW ENGLAND JOURNAL OF MEDICINE

68Ga-Complex Lipophilicity and the Targeting Property of a Urea-Based PSMA Inhibitor for PET Imaging

(2012) Matthias Eder et al.   BIOCONJUGATE CHEMISTRY

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

(2012) P. Kievit et al.   DIABETES

PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions

(2012) A. Afshar-Oromieh et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Clinical PET of Neuroendocrine Tumors Using 64Cu-DOTATATE: First-in-Humans Study

(2012) A. Pfeifer et al.   JOURNAL OF NUCLEAR MEDICINE