Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets

Glucocorticoids enhance the anti-leukemic activity of FLT3 inhibitors in FLT3 mutant acute myeloid leukemia

(2020) Melat T. Gebru et al.   BLOOD

Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia

(2020) Melat T. Gebru et al.   Journal of Hematology & Oncology

Targeting FLT3 mutations in AML: review of current knowledge and evidence

(2019) Naval Daver et al.   LEUKEMIA

Cancer cell reprogramming: a promising therapy converting malignancy to benignity

(2019) Lanqi Gong et al.   Cancer Communications

SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update

(2019) Luana Licata et al.   NUCLEIC ACIDS RESEARCH

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

(2019) David J. Wooten et al.   PLoS Computational Biology

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

(2018) François M. Vallette et al.   BIOCHEMICAL PHARMACOLOGY

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

(2018) Marvin Martens et al.   Frontiers in Genetics

Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology

(2017) Margaret R. O'Donnell et al.   Journal of the National Comprehensive Cancer Network

From word models to executable models of signaling networks using automated assembly

(2017) Benjamin M Gyori et al.   Molecular Systems Biology

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

(2017) Heonjong Han et al.   NUCLEIC ACIDS RESEARCH

Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma

(2017) Mark E. Issa et al.   Clinical Epigenetics

Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment

(2017) Shufeng Zhou et al.   PLoS One

A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes

(2017) Jens Hansen et al.   Scientific Reports

GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation

(2016) K. Gupta et al.   CANCER RESEARCH

JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia

(2016) C Zhou et al.   LEUKEMIA

A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity

(2016) Sophia Hu et al.   MOLECULAR CANCER THERAPEUTICS

Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: ‘What does not kill me strengthens me’

(2015) A O Pisco et al.   BRITISH JOURNAL OF CANCER

RegNetwork: an integrated database of transcriptional and post-transcriptional regulatory networks in human and mouse

(2015) Zhi-Ping Liu et al.   Database-The Journal of Biological Databases and Curation

SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells

(2014) Ling Li et al.   Cell Stem Cell

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity

(2014) Yuki Kagoya et al.   JOURNAL OF CLINICAL INVESTIGATION

How to escape the cancer attractor: Rationale and limitations of multi-target drugs

(2013) Sui Huang et al.   SEMINARS IN CANCER BIOLOGY

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

(2012) Julhash U. Kazi et al.   Molecular Oncology

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

(2011) Raghuveer Singh Mali et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

NetPath: a public resource of curated signal transduction pathways

(2010) Kumaran Kandasamy et al.   GENOME BIOLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS