Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

(2016) Nita Ahuja et al.   Annual Review of Medicine

The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma

(2016) C. Pawlyn et al.   CLINICAL CANCER RESEARCH

Epigenetic regulators and their impact on therapy in acute myeloid leukemia

(2016) F. Pastore et al.   HAEMATOLOGICA

Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia)

(2016) Terry Golombick et al.   INTEGRATIVE CANCER THERAPIES

Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial

(2016) Andrew J Yee et al.   LANCET ONCOLOGY

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice

(2016) Dong U. Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies

(2016) Elisabetta Fratta et al.   Oncotarget

Epigenetic regulators and their impact on therapy in acute myeloid leukemia

(2016) F. Pastore et al.   HAEMATOLOGICA

Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study

(2016) Sandy Amorim et al.   Lancet Haematology

Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib

(2015) B. Sun et al.   BLOOD

Global hypomethylation in myeloma is associated with poor prognosis

(2015) Jonathan I. Sive et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death

(2015) Yuko Mishima et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting the canonical Wnt/β-catenin pathway in hematological malignancies

(2015) Eishi Ashihara et al.   CANCER SCIENCE

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

(2015) Xabier Agirre et al.   GENOME RESEARCH

Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma

(2015) Jiro Kikuchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression

(2015) Yupeng Zheng et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of Histone Deacetylase Inhibitors in Relapsed Refractory Multiple Myeloma: A Focus on Vorinostat and Panobinostat

(2015) Salma Afifi et al.   PHARMACOTHERAPY

Histone deacetylase 6 in health and disease

(2015) Carole Seidel et al.   Epigenomics

In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma

(2015) Ken Maes et al.   Oncotarget

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

(2015) Jahangir Abdi et al.   Oncotarget

Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity

(2015) Lavinia Raimondi et al.   Oncotarget

The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma

(2015) Ken Maes et al.   Oncotarget

Absolute Quantification of Histone PTM Marks by MRM-Based LC-MS/MS

(2014) Jun Gao et al.   ANALYTICAL CHEMISTRY

Somatic alterations and dysregulation of epigenetic modifiers in cancers

(2014) Shlomzion Aumann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

(2014) Sridurga Mithraprabhu et al.   Epigenetics

Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer

(2014) You-Wei Zhang et al.   Epigenetics

Understanding the multiple biological aspects leading to myeloma

(2014) E. M. Boyle et al.   HAEMATOLOGICA

Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial

(2014) Jesús F San-Miguel et al.   LANCET ONCOLOGY

Enhancer of zeste homolog 2 is widely expressed in T-cell neoplasms, is associated with high proliferation rate and correlates with MYC and pSTAT3 expression in a subset of cases

(2014) Min Shi et al.   LEUKEMIA & LYMPHOMA

The role of P-glycoprotein in drug resistance in multiple myeloma

(2014) Joseph Abraham et al.   LEUKEMIA & LYMPHOMA

BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD

(2014) W. Fiskus et al.   MOLECULAR CANCER THERAPEUTICS

Global Epigenetic Regulation of MicroRNAs in Multiple Myeloma

(2014) Wenjing Zhang et al.   PLoS One

miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation

(2014) J Kureel et al.   Cell Death & Disease

The role of epigenetics in the biology of multiple myeloma

(2014) K Dimopoulos et al.   Blood Cancer Journal

Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma

(2014) Immacolata Scognamiglio et al.   Biomed Research International

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2013) P. Moreau et al.   ANNALS OF ONCOLOGY

Perspectives and future directions for epigenetics in hematology

(2013) M. A. Goodell et al.   BLOOD

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

(2013) M. F. Kaiser et al.   BLOOD

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

Fact or fiction - identifying the elusive multiple myeloma stem cell

(2013) Joshua Kellner et al.   Journal of Hematology & Oncology

Myeloma Is Characterized by Stage-Specific Alterations in DNA Methylation That Occur Early during Myelomagenesis

(2013) C. J. Heuck et al.   JOURNAL OF IMMUNOLOGY

Signal Transduction Pathways and Transcriptional Mechanisms of ABCB1/Pgp-mediated Multiple Drug Resistance in Human Cancer Cells

(2013) H Sui et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

(2013) J Minami et al.   LEUKEMIA

Impact of global and gene-specific DNA methylation pattern in relapsed multiple myeloma patients treated with bortezomib

(2013) Carlos Fernández de Larrea et al.   LEUKEMIA RESEARCH

MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells

(2013) A Formosa et al.   ONCOGENE

Epigenetic Modulating Agents as a New Therapeutic Approach in Multiple Myeloma

(2013) Ken Maes et al.   Cancers

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

Bone Marrow Microenvironment in Multiple Myeloma Progression

(2012) S. Manier et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Histone Methyltransferase NSD2/MMSET Mediates Constitutive NF- B Signaling for Cancer Cell Proliferation, Survival, and Tumor Growth via a Feed-Forward Loop

(2012) P. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Development of Gene Expression-Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors

(2012) J. Moreaux et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetic alterations involved in cancer stem cell reprogramming

(2012) Purificación Muñoz et al.   Molecular Oncology

Colorectal Cancer Stem Cells

(2012) Aristides G. Vaiopoulos et al.   STEM CELLS

Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials

(2011) P. M. Fayers et al.   BLOOD

Regulation of mammalian DNA methyltransferases: a route to new mechanisms

(2011) Hélène Denis et al.   EMBO REPORTS

Epigenetic regulation of miRNA genes in acute leukemia

(2011) X Agirre et al.   LEUKEMIA

Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study

(2011) S K Kumar et al.   LEUKEMIA

Mechanism of Action of Proteasome Inhibitors and Deacetylase Inhibitors and the Biological Basis of Synergy in Multiple Myeloma

(2011) T. Hideshima et al.   MOLECULAR CANCER THERAPEUTICS

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Treatment of multiple myeloma

(2011) S. Vincent Rajkumar   Nature Reviews Clinical Oncology

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic modulation: a novel therapeutic target for overcoming hormonal therapy resistance

(2011) Paromita Raha et al.   Epigenomics

NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biological Considerations of Hematological Relapse following Allogeneic Stem Cell Transplantation Unrelated to Graft-versus-Tumor Effects: State of the Science

(2010) Mitchell S. Cairo et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma

(2010) B. A. Walker et al.   BLOOD

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

(2010) E. Martinez-Garcia et al.   BLOOD

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

(2010) Bin Zhang et al.   CANCER CELL

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

(2010) Flavia Pichiorri et al.   CANCER CELL

DNA Methylation Analysis Determines the High Frequency of Genic Hypomethylation and Low Frequency of Hypermethylation Events in Plasma Cell Tumors

(2010) B. Salhia et al.   CANCER RESEARCH

Cancer Stem Cells and Self-renewal

(2010) C. A. O'Brien et al.   CLINICAL CANCER RESEARCH

Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling

(2010) Bokyung Sung et al.   INTERNATIONAL JOURNAL OF CANCER

Notch Signaling Pathway as a Therapeutic Target in Breast Cancer

(2010) H. Al-Hussaini et al.   MOLECULAR CANCER THERAPEUTICS

DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer

(2010) Amy Sharma et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

(2009) O. Landgren et al.   BLOOD

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

(2009) A. M. Roccaro et al.   BLOOD

Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma

(2009) P. Ghoshal et al.   CANCER RESEARCH

Differential repetitive DNA methylation in multiple myeloma molecular subgroups

(2009) V. Bollati et al.   CARCINOGENESIS

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

 -Catenin Small Interfering RNA Successfully Suppressed Progression of Multiple Myeloma in a Mouse Model

(2009) E. Ashihara et al.   CLINICAL CANCER RESEARCH

Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma

(2009) M. Nojima et al.   CLINICAL CANCER RESEARCH

TGFβR2aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma

(2009) Fabrício de Carvalho et al.   INTERNATIONAL JOURNAL OF CANCER

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma

(2009) Livia Garzia et al.   PLoS One

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression

(2008) María J. Bueno et al.   CANCER CELL

Polycomb complexes and epigenetic states

(2008) Yuri B Schwartz et al.   CURRENT OPINION IN CELL BIOLOGY

Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma

(2008) Guanghua Chen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

(2008) Marina Tshuikina et al.   EXPERIMENTAL HEMATOLOGY

The effect of azacitidine on interleukin-6 signaling and nuclear factor- B activation and its in vitro and in vivo activity against multiple myeloma

(2008) T. Khong et al.   HAEMATOLOGICA

Multiple Myeloma Cancer Stem Cells

(2008) Carol Ann Huff et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

(2008) M A Hussein et al.   LEUKEMIA

Polymorphisms and haplotypes in the multidrug resistance 1 gene (MDR1/ABCB1) and risk of multiple myeloma

(2008) Krzysztof Jamroziak et al.   LEUKEMIA RESEARCH

Nucleoside analogs: molecular mechanisms signaling cell death

(2008) B Ewald et al.   ONCOGENE

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

(2008) F. Pichiorri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

(2007) J. Marango et al.   BLOOD