Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome

Exploring the therapeutic potential of modern and ancestral phenylalanine/tyrosine ammonia-lyases as supplementary treatment of hereditary tyrosinemia

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Evolutionary redesign of the lysosomal enzyme arylsulfatase A increases efficacy of enzyme replacement therapy for metachromatic leukodystrophy

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Protein-Engineered Coagulation Factors for Hemophilia Gene Therapy

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Enzyme replacement therapy for mucopolysaccharidoses; past, present, and future

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Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs

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Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction

(2019) Michael Schupfner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inferring the mammal tree: Species-level sets of phylogenies for questions in ecology, evolution, and conservation

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A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II

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Ancestral diterpene cyclases show increased thermostability and substrate acceptance

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nanoDSF as screening tool for enzyme libraries and biotechnology development

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Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily

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Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction

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Ten plus one challenges in diseases of the lysosomal system

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Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

(2017) Mykhaylo Demydchuk et al.   Nature Communications

Development of idursulfase therapy for mucopolysaccharidosis type II (Hunter syndrome): the past, the present and the future

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Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro approach to protein engineering

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Ancestral protein reconstruction: techniques and applications

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Comparative study of idursulfase beta and idursulfase in vitro and in vivo

(2016) Chihwa Kim et al.   JOURNAL OF HUMAN GENETICS

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

(2016) Philip M Zakas et al.   NATURE BIOTECHNOLOGY

Evolutionary drivers of thermoadaptation in enzyme catalysis

(2016) Vy Nguyen et al.   SCIENCE

Using ancient protein kinases to unravel a modern cancer drug's mechanism

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A biochemical and physicochemical comparison of two recombinant enzymes used for enzyme replacement therapies of hunter syndrome

(2014) Yo Kyung Chung et al.   GLYCOCONJUGATE JOURNAL

Evolutionary history and metabolic insights of ancient mammalian uricases

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Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

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Lysosomal storage diseases—the horizon expands

(2013) Rose-Mary Naaman Boustany   Nature Reviews Neurology

Phase I/II clinical trial of enzyme replacement therapy with idursulfase beta in patients with mucopolysaccharidosis II (Hunter Syndrome)

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Enzyme Replacement Therapy for Lysosomal Diseases: Lessons from 20 Years of Experience and Remaining Challenges

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