Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs

Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO)

(2019) Nikola Lončar et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases

(2019) Maximilian JLJ Fürst et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes

(2018) Elvira Romero et al.   CHEMICAL REVIEWS

Biotechnological and protein-engineering implications of ancestral protein resurrection

(2018) Valeria A Risso et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Renewing Felsenstein’s phylogenetic bootstrap in the era of big data

(2018) F. Lemoine et al.   NATURE

Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus

(2018) Christian Kubitza et al.   Acta Crystallographica Section D-Structural Biology

Monotopic Membrane Proteins Join the Fold

(2018) Karen N. Allen et al.   TRENDS IN BIOCHEMICAL SCIENCES

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times

(2017) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamineN-oxide

(2017) Chun-Yang Li et al.   MOLECULAR MICROBIOLOGY

Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster

(2017) Mohammad A. Siddiq et al.   Nature Ecology & Evolution

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

(2016) Filippo Fiorentini et al.   ACS Chemical Biology

Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase

(2016) Elvira Romero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The thermostability and specificity of ancient proteins

(2016) Lucas C Wheeler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases

(2016) Maria Laura Mascotti et al.   JOURNAL OF MOLECULAR BIOLOGY

A new view of the tree of life

(2016) Laura A. Hug et al.   Nature Microbiology

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

(2015) Sandra G. Gonzalez Malagon et al.   BIOCHEMICAL PHARMACOLOGY

Stock-based detection of protein oligomeric states in jsPISA

(2015) Eugene Krissinel   NUCLEIC ACIDS RESEARCH

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

(2015) S. F. Leiser et al.   SCIENCE

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

The Origin and Evolution of Baeyer—Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases

(2015) Maria Laura Mascotti et al.   PLoS One

Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide

(2014) Lisbeth K. Siddens et al.   BIOCHEMICAL PHARMACOLOGY

Flavin Monooxygenase Metabolism: Why Medicinal Chemists Should Matter

(2014) Gabriele Cruciani et al.   JOURNAL OF MEDICINAL CHEMISTRY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Flavin dependent monooxygenases

(2013) Mieke M.E. Huijbers et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism

(2010) Elizabeth A Shephard et al.   Expert Opinion on Drug Metabolism & Toxicology

Joint Functions of Protein Residues and NADP(H) in Oxygen Activation by Flavin-containing Monooxygenase

(2010) Roberto Orru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K

(2009) S. K. Krueger et al.   DRUG METABOLISM AND DISPOSITION

ThermoFAD, aThermofluor®-adapted flavinad hocdetection system for protein folding and ligand binding

(2009) Federico Forneris et al.   FEBS Journal

Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases

(2009) Da Cheng Hao et al.   GENETICA

Kinetic Mechanism of Phenylacetone Monooxygenase fromThermobifida fusca†

(2008) Daniel E. Torres Pazmiño et al.   BIOCHEMISTRY

Role of flavin-containing monooxgenase in drug development

(2008) John R Cashman   Expert Opinion on Drug Metabolism & Toxicology

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

(2008) Krishna R. Veeramah et al.   Pharmacogenetics and Genomics

Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase

(2008) A. Alfieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flavin-containing monooxygenases: mutations, disease and drug response

(2008) I PHILLIPS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling

(2008) Benoit Adam et al.   BMC STRUCTURAL BIOLOGY