Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice

Phase 1 Clinical Study of Mgta-145 in Combination with Plerixafor Shows Rapid Single-Day Mobilization and Collection of CD34+ HSCs without G-CSF

(2020) John F. DiPersio et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model

(2020) Chang Li et al.   MOLECULAR THERAPY

Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements

(2020) Hongjie Wang et al.   JCI Insight

Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells

(2019) Darja Karpova et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors

(2019) Chang Li et al.   MOLECULAR THERAPY

Viagra Enables Efficient, Single-Day Hematopoietic Stem Cell Mobilization

(2019) Stephanie Smith-Berdan et al.   Stem Cell Reports

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

(2018) Jonathan Hoggatt et al.   CELL

Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies

(2018) Chang Li et al.   Molecular Therapy-Methods & Clinical Development

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

(2018) Hongjie Wang et al.   Molecular Therapy-Methods & Clinical Development

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia

(2018) Hongjie Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

(2016) M. Richter et al.   BLOOD

A High-Capacity Adenoviral Hybrid Vector System Utilizing the Hyperactive Sleeping Beauty Transposase SB100X for Enhanced Integration

(2016) Philip Boehme et al.   Molecular Therapy-Nucleic Acids

How I treat patients who mobilize hematopoietic stem cells poorly

(2011) L. B. To et al.   BLOOD

CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions

(2011) Jung-Eun Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

review: Current status of stem cell mobilization

(2010) Morie A. Gertz   BRITISH JOURNAL OF HAEMATOLOGY

A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone: results of a European phase II study

(2010) Stefan Fruehauf et al.   CYTOTHERAPY

Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma

(2009) J. F. DiPersio et al.   BLOOD

Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100

(2009) Halvard Bonig et al.   EXPERIMENTAL HEMATOLOGY

Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma

(2009) John F. DiPersio et al.   JOURNAL OF CLINICAL ONCOLOGY

Ontogeny of erythropoiesis

(2008) James Palis   CURRENT OPINION IN HEMATOLOGY

In Vitro and In Vivo Properties of Adenovirus Vectors with Increased Affinity to CD46

(2008) H. Wang et al.   JOURNAL OF VIROLOGY