The PD-L1 metabolic interactome intersects with choline metabolism and inflammation

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

(2020) Hanne Lind et al.   Journal for ImmunoTherapy of Cancer

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

(2019) Cecilia Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

The Clinical Trial Landscape for Melanoma Therapies

(2019) Sonia Wróbel et al.   Journal of Clinical Medicine

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

(2019) Shamir Cassim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells

(2018) Elena Mariotto et al.   BIOCHEMICAL PHARMACOLOGY

Identification of a Unique Inhibitor-Binding Site on Choline Kinase α

(2018) Stefanie L. Kall et al.   BIOCHEMISTRY

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

(2018) Rajani Ravi et al.   Nature Communications

Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft

(2018) Santosh K. Bharti et al.   Oncotarget

Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy

(2018) Soumaya Kouidhi et al.   Frontiers in Immunology

Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer

(2018) KATSUHIKO SHIMIZU et al.   ANTICANCER RESEARCH

Immunometabolism in cancer at a glance

(2018) Katrin Singer et al.   Disease Models & Mechanisms

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion

(2018) Peixin Dong et al.   Frontiers in Oncology

Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer

(2018) Honglin Tang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

(2018) Frederike Bensch et al.   NATURE MEDICINE

The UCSC Genome Browser database: 2019 update

(2018) Maximilian Haeussler et al.   NUCLEIC ACIDS RESEARCH

The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ

(2018) Liping Wang et al.   OncoTargets and Therapy

Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

(2018) Elena Mariotto et al.   Cancers

Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion

(2018) Xichun Xia et al.   Frontiers in Oncology

Immunotherapy for pancreatic cancer: present and future

(2017) Francesca Aroldi et al.   Immunotherapy

COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

(2017) Gerardo Botti et al.   Journal of Translational Medicine

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

(2017) Victor Prima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of immune evasion in breast cancer

(2017) Mozhi Wang et al.   OncoTargets and Therapy

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

(2017) Zhiyuan Niu et al.   Nature Communications

Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

(2017) Balaji Krishnamachary et al.   Oncotarget

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration

(2017) Elena Brin et al.   Oncotarget

Fatty Acid Uptake in T Cell Subsets Using a Quantum Dot Fatty Acid Conjugate

(2017) Megan E. Muroski et al.   Scientific Reports

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

(2017) Seema Gupta et al.   Frontiers in Oncology

Dichotomous roles of TGF-β in human cancer

(2016) Jennifer J. Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

(2016) Curtis A. Clark et al.   CANCER RESEARCH

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

(2016) Sangbin Lim et al.   CANCER RESEARCH

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery

(2016) Stephan G. Zech et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma

(2016) Liang Hu et al.   Oncotarget

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth

(2016) Sebastian Trousil et al.   Oncotarget

Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy

(2016) Zhihang Chen et al.   Nanomaterials

Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells

(2016) Frederik C. Henrich et al.   OncoImmunology

TLR3 triggering regulates PD-L1 (CD274) expression in human neuroblastoma cells

(2015) Marianne Boes et al.   CANCER LETTERS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Choline metabolism-based molecular diagnosis of cancer: an update

(2015) Kristine Glunde et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer

(2015) Amarnath Challapalli et al.   JOURNAL OF CLINICAL PATHOLOGY

Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting

(2015) J Xiong et al.   Blood Cancer Journal

Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor

(2014) Takumi Kumai et al.   Journal of Translational Medicine

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

COX-2 in cancer: Gordian knot or Achilles heel?

(2013) Ioannis Stasinopoulos et al.   Frontiers in Pharmacology

Choline Kinase Alpha and Hexokinase-2 Protein Expression in Hepatocellular Carcinoma: Association with Survival

(2012) Sandi A. Kwee et al.   PLoS One

A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling

(2011) B F Clem et al.   ONCOGENE

TGF-β1 Reverses Inhibition of COX-2 With NS398 and Increases Invasion in Prostate Cancer Cells

(2010) Qiang Ding et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

(2009) Boon Chua et al.   Molecular Cancer

Nimesulide inhibits IFN-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms

(2008) Mei Liang et al.   CANCER LETTERS

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE