Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines

(2020) Xin Liu et al.   Journal of Genetics and Genomics

Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design

(2020) Shan-Meng Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

The COVID‐19 epidemic

(2020) Thirumalaisamy P. Velavan et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More

(2020) Abinit Saha et al.   ARCHIVES OF MEDICAL RESEARCH

Progress and Concept for COVID‐19 Vaccine Development

(2020) Suh‐Chin Wu   Biotechnology Journal

Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection

(2020) David N. Juurlink   CANADIAN MEDICAL ASSOCIATION JOURNAL

Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study

(2020) N. Lian et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antiviral Activity of Chitosan Nanoparticles Encapsulating Curcumin Against Hepatitis C Virus Genotype 4a in Human Hepatoma Cell Lines

(2020) Samah A Loutfy et al.   International Journal of Nanomedicine

Antiviral Peptides: Identification and Validation

(2020) Garima Agarwal et al.   International Journal of Peptide Research and Therapeutics

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study

(2020) Lisi Deng et al.   JOURNAL OF INFECTION

Aluminum Nanoparticles Acting as a Pulmonary Vaccine Adjuvant-Delivery System (VADS) Able to Safely Elicit Robust Systemic and Mucosal Immunity

(2020) Ning Wang et al.   Journal of Inorganic and Organometallic Polymers and Materials

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Traditional Chinese Medicine treatment of COVID-19

(2020) Jia Xu et al.   Complementary Therapies in Clinical Practice

Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19

(2020) Li Ni et al.   Frontiers of Medicine

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

COVID-19 vaccines: breaking record times to first-in-human trials

(2020) Young Chan Kim et al.   npj Vaccines

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

Nanotechnology for COVID-19: Therapeutics and Vaccine Research

(2020) Gaurav Chauhan et al.   ACS Nano

Current status of COVID‐19 (pre)clinical vaccine development

(2020) Bruno de Geest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

(2020) Dong Huang et al.   JOURNAL OF MEDICAL VIROLOGY

Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2

(2020) Parismita Kalita et al.   MICROBIAL PATHOGENESIS

Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

(2020) Qiangzhe Zhang et al.   NANO LETTERS

Nanomedicine as a promising approach for diagnosis, treatment and prophylaxis against COVID-19

(2020) Noura H Abd Ellah et al.   Nanomedicine

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

(2020) Brandi N. Williamson et al.   NATURE

Nanotechnology-based antiviral therapeutics

(2020) Malobika Chakravarty et al.   Drug Delivery and Translational Research

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

(2020) Mayla Gabriela Silva Borba et al.   JAMA Network Open

Safety profile of the antiviral drug remdesivir: An update

(2020) Qianqian Fan et al.   BIOMEDICINE & PHARMACOTHERAPY

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

(2020) Ramarao Poduri et al.   CELLULAR SIGNALLING

A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection

(2020) Yasmin Abo-zeid et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prospective vaccination of COVID-19 using shRNA-plasmid-LDH nanoconjugate

(2020) Rituparna Acharya   MEDICAL HYPOTHESES

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

(2020) Estefânia V. R. Campos et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients

(2020) Hamed Valizadeh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for COVID-19 Treatment

(2020) Bwalya A. Witika et al.   MOLECULES

Perspectives in Peptide-Based Vaccination Strategies for Syndrome Coronavirus 2 Pandemic

(2020) Concetta Di Natale et al.   Frontiers in Pharmacology

A Potential Peptide From Soy Cheese Produced Using Lactobacillus delbrueckii WS4 for Effective Inhibition of SARS-CoV-2 Main Protease and S1 Glycoprotein

(2020) Rounak Chourasia et al.   Frontiers in Molecular Biosciences

Gold nanoparticles and hepatitis B virus

(2019) Babak Negahdari et al.   Artificial Cells Nanomedicine and Biotechnology

Engineered Nanomaterials as Potential Candidates for HIV Treatment: Between Opportunities and Challenges

(2019) M. Abd Elkodous et al.   JOURNAL OF CLUSTER SCIENCE

Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

(2019) Leon Chien‐Wei Lin et al.   ADVANCED FUNCTIONAL MATERIALS

Antiviral Activities of Human Host Defense Peptides

(2019) David C. Brice et al.   CURRENT MEDICINAL CHEMISTRY

Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection

(2019) Dorothea Morris et al.   Viruses-Basel

Gold nanoparticle‐adjuvanted S protein induces a strong antigen‐specific IgG response against severe acute respiratory syndrome‐related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs

(2019) Hanako Sekimukai et al.   MICROBIOLOGY AND IMMUNOLOGY

Peptide-Based Vaccines: Current Progress and Future Challenges

(2019) Ryan J. Malonis et al.   CHEMICAL REVIEWS

Adjuvant strategies to improve vaccination of the elderly population

(2018) Birgit Weinberger   CURRENT OPINION IN PHARMACOLOGY

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection

(2018) Annette E. LaBauve et al.   Scientific Reports

Prospects for the use of spherical gold nanoparticles in immunization

(2018) Sergey A. Staroverov et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses

(2017) Michael K. Lo et al.   Scientific Reports

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries

(2014) Aaron C. Anselmo et al.   ACS Nano

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

Polymeric Nanoparticles Containing Combination Antiretroviral Drugs for HIV Type 1 Treatment

(2013) Annemarie Shibata et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Membranotropic Effects of Arbidol, a Broad Anti-Viral Molecule, on Phospholipid Model Membranes

(2010) José Villalaín   JOURNAL OF PHYSICAL CHEMISTRY B

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Combination antiretroviral drugs in PLGA nanoparticle for HIV-1

(2009) Christopher J Destache et al.   BMC INFECTIOUS DISEASES