Safety, Immunogenicity, and Protective Efficacy of a Chimeric A/B Live Attenuated Influenza Vaccine in a Mouse Model

Insights into current clinical research on the immunogenicity of live attenuated influenza vaccines

(2020) Irina Isakova-Sivak et al.   Expert Review of Vaccines

Recombinant Live Attenuated Influenza Vaccine Viruses Carrying Conserved T-cell Epitopes of Human Adenoviruses Induce Functional Cytotoxic T-Cell Responses and Protect Mice against Both Infections

(2020) Irina Isakova-Sivak et al.   Vaccines

Imprinting, immunodominance, and other impediments to generating broad influenza immunity

(2020) Matthew Knight et al.   IMMUNOLOGICAL REVIEWS

Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study

(2019) Benjamin B Lindsey et al.   Lancet Respiratory Medicine

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

(2019) Manon Laporte et al.   JOURNAL OF VIROLOGY

Influenza B Viruses Exhibit Lower Within-Host Diversity than Influenza A Viruses in Human Hosts

(2019) Andrew L. Valesano et al.   JOURNAL OF VIROLOGY

Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages

(2018) Karen L Laurie et al.   JOURNAL OF INFECTIOUS DISEASES

Broadly protective anti-hemagglutinin stalk antibodies induced by live attenuated influenza vaccine expressing chimeric hemagglutinin

(2018) Irina Isakova-Sivak et al.   VIROLOGY

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

(2018) Jeremy C. Jones et al.   mBio

Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses

(2018) Min Zhao et al.   mBio

A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals

(2018) Wenyu Yang et al.   Emerging Microbes & Infections

Boosting of Cross-Reactive and Protection-Associated T Cells in Children After Live Attenuated Influenza Vaccination

(2017) Kristin G. I. Mohn et al.   JOURNAL OF INFECTIOUS DISEASES

Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model

(2017) Irina Isakova-Sivak et al.   VIROLOGY

Immunogenicity and Cross Protection in Mice Afforded by Pandemic H1N1 Live Attenuated Influenza Vaccine Containing Wild-Type Nucleoprotein

(2017) Andrey Rekstin et al.   Biomed Research International

Distinct susceptibility and applicability of MDCK derivatives for influenza virus research

(2017) Shih-Chao Lin et al.   PLoS One

Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

(2016) Daniel F. Hoft et al.   Clinical and Vaccine Immunology

Reassortant viruses for influenza vaccines: is it time to reconsider their genome structures?

(2016) Irina Isakova-Sivak et al.   Expert Review of Vaccines

Development and approval of live attenuated influenza vaccines based on Russian master donor viruses: Process challenges and success stories

(2016) Larisa Rudenko et al.   VACCINE

Replication-competent fluorescent-expressing influenza B virus

(2016) Aitor Nogales et al.   VIRUS RESEARCH

Replication-Competent Influenza A Viruses Expressing Reporter Genes

(2016) Michael Breen et al.   Viruses-Basel

A comprehensive review of the epidemiology and disease burden of Influenza B in 9 European countries

(2016) Monica Tafalla et al.   Human Vaccines & Immunotherapeutics

Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study

(2015) Saverio Caini et al.   Influenza and Other Respiratory Viruses

Influenza B virus-specific CD8+ T-lymphocytes strongly cross-react with viruses of the opposing influenza B lineage

(2015) Carolien E. van de Sandt et al.   JOURNAL OF GENERAL VIROLOGY

Antiviral B cell and T cell immunity in the lungs

(2015) Christopher Chiu et al.   NATURE IMMUNOLOGY

Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model

(2014) Irina Isakova-Sivak et al.   Clinical and Vaccine Immunology

T-cell-mediated cross-strain protective immunity elicited by prime–boost vaccination with a live attenuated influenza vaccine

(2014) Junwei Li et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Influenza A and B Virus Intertypic Reassortment through Compatible Viral Packaging Signals

(2014) S. F. Baker et al.   JOURNAL OF VIROLOGY

A Single Amino Acid in the Stalk Region of the H1N1pdm Influenza Virus HA Protein Affects Viral Fusion, Stability and Infectivity

(2014) Christopher R. Cotter et al.   PLoS Pathogens

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development

(2014) Madhu Khanna et al.   Biomed Research International

The Burden of Influenza B: A Structured Literature Review

(2013) W. Paul Glezen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Receptor binding and pH stability — How influenza A virus hemagglutinin affects host-specific virus infection

(2013) Caroline M. Mair et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mutations of two transmembrane cysteines of hemagglutinin (HA) from influenza A H3N2 virus affect HA thermal stability and fusion activity

(2013) Shun Xu et al.   VIRUS GENES

Multiple Distinct Forms of CD8+ T Cell Cross-Reactivity and Specificities Revealed after 2009 H1N1 Influenza A Virus Infection in Mice

(2012) Hailong Guo et al.   PLoS One

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Inhibition of influenza A virus replication by influenza B virus nucleoprotein: An insight into interference between influenza A and B viruses

(2012) Asawin Wanitchang et al.   VIROLOGY

Single HA2 Mutation Increases the Infectivity and Immunogenicity of a Live Attenuated H5N1 Intranasal Influenza Vaccine Candidate Lacking NS1

(2011) Brigitte M. Krenn et al.   PLoS One

Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1

(2011) Sabine Nakowitsch et al.   VACCINE

Genetic bases of the temperature-sensitive phenotype of a master donor virus used in live attenuated influenza vaccines: A/Leningrad/134/17/57 (H2N2)

(2011) Irina Isakova-Sivak et al.   VIROLOGY

T Cell-Mediated Protection against Lethal 2009 Pandemic H1N1 Influenza Virus Infection in a Mouse Model

(2010) H. Guo et al.   JOURNAL OF VIROLOGY

Significant Impact of Sequence Variations in the Nucleoprotein on CD8 T Cell-Mediated Cross-Protection against Influenza A Virus Infections

(2010) Weimin Zhong et al.   PLoS One

Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype

(2010) Parveen Salahuddin et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Changes of the receptor-binding properties of influenza B virus B/Victoria/504/2000 during adaptation in chicken eggs

(2009) Vladimir Y. Lugovtsev et al.   VIROLOGY

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

The Evolutionary Dynamics of Human Influenza B Virus

(2008) Rubing Chen et al.   JOURNAL OF MOLECULAR EVOLUTION

Crystal Structure of Unliganded Influenza B Virus Hemagglutinin

(2008) Q. Wang et al.   JOURNAL OF VIROLOGY

Limited compatibility between the RNA polymerase components of influenza virus type A and B

(2008) Kiyoko Iwatsuki-Horimoto et al.   VIRUS RESEARCH