Emerging roles of immunoproteasomes beyond MHC class I antigen processing

Immunoproteasome expression is induced in mesial temporal lobe epilepsy

(2011) Michele Mishto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Immunoproteasomes Regulate LPS-Induced TRIF/TRAM Signaling Pathway in Murine Macrophages

(2011) Julia Reis et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

(2011) D A T Nijholt et al.   CELL DEATH AND DIFFERENTIATION

The immunoproteasome in steatohepatitis: Its role in Mallory–Denk body formation

(2011) B.A. French et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

(2011) K. Arima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis

(2011) Elisa Opitz et al.   PLoS Pathogens

Studies on immunoproteasome in human liver. Part I: Absence in fetuses, presence in normal subjects, and increased levels in chronic active hepatitis and cirrhosis

(2010) Francesco Vasuri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

The Hepatic Genes for Immunoproteasome Are Upregulated by Refeeding after Fasting in the Rat

(2010) Shota USHIAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo

(2010) Ajita V. Singh et al.   BRITISH JOURNAL OF HAEMATOLOGY

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

(2010) Jacqueline Moebius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model

(2010) Fawzia Bardag-Gorce et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis

(2010) N. Schmidt et al.   GUT

Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice

(2010) M. Kremer et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic Reticulum Stress-Mediated Apoptosis of EBV-Transformed B Cells by Cross-Linking of CD70 Is Dependent upon Generation of Reactive Oxygen Species and Activation of p38 MAPK and JNK Pathway

(2010) G. B. Park et al.   JOURNAL OF IMMUNOLOGY

Unexpected Role for the Immunoproteasome Subunit LMP2 in Antiviral Humoral and Innate Immune Responses

(2010) S. E. Hensley et al.   JOURNAL OF IMMUNOLOGY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice

(2010) Lingyun Zu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population

(2010) Michele Mishto et al.   PLoS One

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

(2010) B. Guillaume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Pattern of Immunoproteasome Subunits in Human Thymus

(2010) Kwon Ik Oh et al.   Immune Network

Cardiovascular Inflammation and Lesion Cell Apoptosis

(2009) Zhaoqing Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences

(2009) Jonathan P. Godbout et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Expression of catalytic proteasome subunits in the gut of patients with Crohn’s disease

(2009) Alexander Visekruna et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Synaptic Proteins Linked to HIV-1 Infection and Immunoproteasome Induction: Proteomic Analysis of Human Synaptosomes

(2009) Benjamin B. Gelman et al.   Journal of Neuroimmune Pharmacology

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD

Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency

(2008) Zheqing P. Cai et al.   FASEB JOURNAL

Comparative expression analysis and characterization of 20S proteasomes in human intestinal tissues

(2008) Alexander Visekruna et al.   INFLAMMATORY BOWEL DISEASES

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

(2008) Frédéric Ebstein et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immunoproteasome responds to injury in the retina and brain

(2008) Deborah A. Ferrington et al.   JOURNAL OF NEUROCHEMISTRY

Age-related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects

(2008) M. Paz Gavilán et al.   JOURNAL OF NEUROCHEMISTRY

Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy

(2008) Rosanna Coppo et al.   KIDNEY INTERNATIONAL

Candida albicanscell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance

(2008) Ingrid E. Frohner et al.   MOLECULAR MICROBIOLOGY