Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies

Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities

(2021) Li-Yen Lee et al.   LIFE SCIENCES

αIIb-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis

(2020) Mats W. Johansson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil and mast cell Siglecs: From biology to drug target

(2020) Jeremy A. O'Sullivan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity

(2020) Rodrigo Jiménez-Saiz et al.   Frontiers in Immunology

Morphological and phenotypical diversity of eosinophils in the rat ileum

(2020) Masaya Arai et al.   CELL AND TISSUE RESEARCH

Dietary fiber metabolites regulate innate lymphoid cell responses

(2020) Ali Sepahi et al.   Mucosal Immunology

Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation

(2020) Courtney L. Olbrich et al.   Mucosal Immunology

The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses

(2020) Isabelle C. Arnold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

(2020) Evan S. Dellon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergic diseases

(2020) Jun Miyata et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Discovery, Function, and Therapeutic Targeting of Siglec-8

(2020) Bradford A. Youngblood et al.   Cells

Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

(2019) Hadar Reichman et al.   Cancer Immunology Research

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

(2019) Anna Theiler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity

(2019) Girish Hiremath et al.   Clinical and Translational Gastroenterology

Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16

(2019) Michelle Ma et al.   JOURNAL OF IMMUNOLOGY

Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders

(2019) Alexandre Loktionov   WORLD JOURNAL OF GASTROENTEROLOGY

Gut eosinophils and their impact on the mucus‐resident microbiota

(2019) Gurdeep Singh et al.   IMMUNOLOGY

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation

(2019) Gavin Lewis et al.   Frontiers in Immunology

The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020

(2019) Hans-Uwe Simon et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Interleukin‐5 drives glycolysis and reactive oxygen species‐dependent citric acid cycling by eosinophils

(2019) Nicholas Jones et al.   ALLERGY

The atopic march

(2018) David A. Hill et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The Eosinophil: for better or worse, in sickness and in health

(2018) Bruce S. Bochner   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The Role of the Environment in Eosinophilic Esophagitis

(2018) Paul J. Dowling et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants

(2018) Huey-Huey Chua et al.   GASTROENTEROLOGY

Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils

(2018) Jason J. Xenakis et al.   IMMUNOLOGY

Integrin αM activation and upregulation on esophageal eosinophils and periostin-mediated eosinophil survival in eosinophilic esophagitis

(2018) Praveen Vimalathas et al.   IMMUNOLOGY AND CELL BIOLOGY

Blood Eosinophil Beta1-Integrin Activation Correlates with Eosinophilic Esophagitis (EoE) Disease Activity

(2018) Mats W. Johansson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation

(2018) Isabelle C. Arnold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

(2018) Hiam Abdala-Valencia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolic Profiling of Human Eosinophils

(2018) Linsey Porter et al.   Frontiers in Immunology

Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death

(2018) Shigeharu Ueki et al.   BLOOD

Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin

(2018) Karina T. Barretto et al.   PLoS One

The nutrition-gut microbiome-physiology axis and allergic diseases

(2017) Craig McKenzie et al.   IMMUNOLOGICAL REVIEWS

CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions

(2017) Perri Rozenberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma

(2017) Evelyn Santos Guerra et al.   PLoS Pathogens

Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing

(2017) Hadar Reichman et al.   Scientific Reports

Metabolism meets immunity: The role of free fatty acid receptors in the immune system

(2016) Elisa Alvarez-Curto et al.   BIOCHEMICAL PHARMACOLOGY

Eosinophils may play regionally disparate roles in influencing IgA+ plasma cell numbers during large and small intestinal inflammation

(2016) Ruth Forman et al.   BMC IMMUNOLOGY

Zero-inflated negative binomial mixed model: an application to two microbial organisms important in oesophagitis

(2016) R. FANG et al.   EPIDEMIOLOGY AND INFECTION

Periostin upregulates the effector functions of eosinophils

(2016) Toru Noguchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung-resident eosinophils represent a distinct regulatory eosinophil subset

(2016) Claire Mesnil et al.   JOURNAL OF CLINICAL INVESTIGATION

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

(2016) Reiko Sugawara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paired Ig-like Receptor B Inhibits IL-13–Driven Eosinophil Accumulation and Activation in the Esophagus

(2016) Netali Ben Baruch-Morgenstern et al.   JOURNAL OF IMMUNOLOGY

Eosinophils, probiotics, and the microbiome

(2016) Helene F. Rosenberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SiglecF + Gr1 hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice

(2016) Caroline M. Percopo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbiota-Regulated IL-25 Increases Eosinophil Number to Provide Protection during Clostridium difficile Infection

(2016) Erica L. Buonomo et al.   Cell Reports

Phenotypic plasticity and targeting of Siglec-FhighCD11cloweosinophils to the airway in a murine model of asthma

(2015) H. Abdala Valencia et al.   ALLERGY

Peroxidase Enzymes Regulate Collagen Extracellular Matrix Biosynthesis

(2015) Mark O. DeNichilo et al.   AMERICAN JOURNAL OF PATHOLOGY

The early history of the eosinophil

(2015) A. B. Kay   CLINICAL AND EXPERIMENTAL ALLERGY

The Eosinophil in Infection

(2015) Karen A. Ravin et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

(2015) Y Jung et al.   Mucosal Immunology

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects

(2015) Fanny Legrand et al.   Journal of Allergy and Clinical Immunology-In Practice

Inflammation-associated microbiota in pediatric eosinophilic esophagitis

(2015) Alain J Benitez et al.   Microbiome

Functional Analysis of Free Fatty Acid Receptor GPR120 in Human Eosinophils: Implications in Metabolic Homeostasis

(2015) Yasunori Konno et al.   PLoS One

Esophageal Microbiome in Eosinophilic Esophagitis

(2015) J. Kirk Harris et al.   PLoS One

Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response

(2015) Valdirene S. Muniz et al.   PLoS One

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

(2014) Joanne C Masterson et al.   GUT

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils

(2014) Mami Tamaki et al.   IMMUNOLOGY LETTERS

Electron microscopy elucidates eosinophil degranulation patterns in patients with eosinophilic esophagitis

(2014) Hedieh Saffari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil Granule Proteins: Form and Function

(2014) K. Ravi Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo

(2014) Derek K. Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinoic Acids Are Potent Inhibitors of Spontaneous Human Eosinophil Apoptosis

(2014) S. Ueki et al.   JOURNAL OF IMMUNOLOGY

Up-Regulation and Activation of Eosinophil Integrins in Blood and Airway after Segmental Lung Antigen Challenge

(2014) M. W. Johansson et al.   JOURNAL OF IMMUNOLOGY

Eosinophil Cytokines, Chemokines, and Growth Factors: Emerging Roles in Immunity

(2014) Francis Davoine et al.   Frontiers in Immunology

Retinoic acids up-regulate functional eosinophil-driving receptor CCR3

(2013) S. Ueki et al.   ALLERGY

The inhibitory receptor CD300a is up-regulated by hypoxia and GM-CSF in human peripheral blood eosinophils

(2013) A. H. Nissim Ben Efraim et al.   ALLERGY

αMβ2Integrin–Mediated Adhesion and Motility of IL-5–Stimulated Eosinophils on Periostin

(2013) Mats W. Johansson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

(2013) S. Ueki et al.   BLOOD

The circadian clock is functional in eosinophils and mast cells

(2013) Anja Baumann et al.   IMMUNOLOGY

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

GM-CSF Produced by Nonhematopoietic Cells Is Required for Early Epithelial Cell Proliferation and Repair of Injured Colonic Mucosa

(2013) L. Egea et al.   JOURNAL OF IMMUNOLOGY

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Activated Eosinophils in Association with Enteric Nerves in Inflammatory Bowel Disease

(2013) Claire M. Smyth et al.   PLoS One

Tissue remodeling in eosinophilic esophagitis

(2012) Edaire Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis

(2012) Payal K. Naik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Platelet Activation, P-Selectin, and Eosinophil β1-Integrin Activation in Asthma

(2012) Mats W. Johansson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules

(2012) Revital Shamri et al.   FASEB JOURNAL

Pattern-recognition receptors in human eosinophils

(2012) Anne Månsson Kvarnhammar et al.   IMMUNOLOGY

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

(2012) Jun Miyata et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Novel Device to Sample the Esophageal Microbiome—The Esophageal String Test

(2012) Sophie A. Fillon et al.   PLoS One

CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling

(2011) Joanne C. Masterson et al.   AMERICAN JOURNAL OF PATHOLOGY

The extracellular matrix: an active or passive player in fibrosis?

(2011) Thomas N. Wight et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pharmacokinetics and Pharmacodynamics of Mepolizumab, an Anti-Interleukin-5 Monoclonal Antibody

(2011) Deborah A. Smith et al.   CLINICAL PHARMACOKINETICS

Immunization induces activation of bone marrow eosinophils required for plasma cell survival

(2011) Van T. Chu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis

(2011) Amal H. Assa'ad et al.   GASTROENTEROLOGY

Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial

(2011) Jonathan M. Spergel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Pan-B Cell Marker CD22 Is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia

(2011) T. Wen et al.   JOURNAL OF IMMUNOLOGY

SIRP /CD172a Regulates Eosinophil Homeostasis

(2011) N. Verjan Garcia et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Regulate Dendritic Cells and Th2 Pulmonary Immune Responses following Allergen Provocation

(2011) E. A. Jacobsen et al.   JOURNAL OF IMMUNOLOGY

Eosinophils are required for the maintenance of plasma cells in the bone marrow

(2011) Van Trung Chu et al.   NATURE IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Eosinophils in innate immunity: an evolving story

(2010) Revital Shamri et al.   CELL AND TISSUE RESEARCH

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro

(2010) P.-C. TAI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

(2010) Tomohiro Yamada et al.   FASEB JOURNAL

Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules

(2010) Josiane S. Neves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

(2010) Roland Kolbeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil Survival and Apoptosis in Health and Disease

(2010) Yong Mean Park et al.   Allergy Asthma & Immunology Research

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors

(2009) B. S. Bochner   CLINICAL AND EXPERIMENTAL ALLERGY

Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine

(2009) P-Y Zheng et al.   GUT

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial

(2009) A Straumann et al.   GUT

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Mouse Eosinophils Possess Potent Antibacterial Properties In Vivo

(2009) S. N. Linch et al.   INFECTION AND IMMUNITY

Common  -Chain-Dependent Signals Confer Selective Survival of Eosinophils in the Murine Small Intestine

(2009) J. Carlens et al.   JOURNAL OF IMMUNOLOGY

A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils

(2008) A. Munitz et al.   BLOOD

Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart

(2008) Paige Snider et al.   CIRCULATION RESEARCH

Eosinophils: Biological Properties and Role in Health and Disease

(2008) SIMON P. HOGAN et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Evaluation of site-specific and seasonal variation in colonic mucosal eosinophils

(2008) Alexandros D. Polydorides et al.   HUMAN PATHOLOGY

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

(2008) Elizabeth A. Jacobsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially

(2008) L. A. Spencer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses

(2008) C Blanchard et al.   Mucosal Immunology

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE