Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Ferroptosis as a novel therapeutic target for Friedreich's ataxia

(2019) M. Grazia Cotticelli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting NRF2 for the Treatment of Friedreich’s Ataxia: A Comparison among Drugs

(2019) Sara Petrillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

(2018) Peiyi Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag

(2018) Khadija Cherif et al.   Molecular Therapy-Nucleic Acids

Alcoholic liver disease

(2018)   Nature Reviews Disease Primers

Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy

(2018) Hongmei Zeng et al.   FOOD AND CHEMICAL TOXICOLOGY

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Simon I Hay et al.   LANCET

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

(2017) Monica Benini et al.   Cell Reports

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Reduction in mitochondrial iron alleviates cardiac damage during injury

(2016) H.-C. Chang et al.   EMBO Molecular Medicine

Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA

(2016) Yee-Ki Lee et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy

(2016) Xiao Yu et al.   Nutrients

Cardioprotective HIF-1α-frataxin signaling against ischemia-reperfusion injury.

(2015) Gayani Nanayakkara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Iron Regulatory Protein 1 Sustains Mitochondrial Iron Loading and Function in Frataxin Deficiency

(2015) Alain Martelli et al.   Cell Metabolism

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

(2015) Aubérie Parent et al.   Nature Communications

Mammalian Fe–S cluster biogenesis and its implication in disease

(2014) Lena K. Beilschmidt et al.   BIOCHIMIE

p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron

(2014) Rina Shimizu et al.   GENE

Protective effects of dioscin against alcohol-induced liver injury

(2013) Tingting Xu et al.   ARCHIVES OF TOXICOLOGY

Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo

(2013) Xiaodong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich's ataxia

(2012) A. Martelli et al.   Disease Models & Mechanisms

Understanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular models

(2012) A. Martelli et al.   Disease Models & Mechanisms

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis

(2011) Balu K. Chacko et al.   HEPATOLOGY

Specific alterations of carbohydrate metabolism are associated with hepatocarcinogenesis in mitochondrially impaired mice

(2011) René Thierbach et al.   HUMAN MOLECULAR GENETICS

Rapamycin reduces oxidative stress in frataxin-deficient yeast cells

(2011) Carlo M.T. Marobbio et al.   MITOCHONDRION

Frataxin participates to the hypoxia-induced response in tumors

(2011) I Guccini et al.   Cell Death & Disease

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

(2010) René Thierbach et al.   BIOCHEMICAL JOURNAL

Does oxidative stress contribute to the pathology of Friedreich’s ataxia? A radical question

(2010) Jeffrey S. Armstrong et al.   FASEB JOURNAL

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARγ pathway as a therapeutic target in Friedreich’s ataxia

(2009) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice

(2008) Yongke Lu et al.   HEPATOLOGY

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

(2008) K. Li et al.   HUMAN MOLECULAR GENETICS