Cognitive Dysfunction in Non-Alcoholic Fatty Liver Disease—Current Knowledge, Mechanisms and Perspectives

Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System

(2020) Jack P. Antel et al.   JOURNAL OF IMMUNOLOGY

Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes

(2020) Eugene Han et al.   Scientific Reports

Neurodegeneration in juvenile Iberian pigs with diet-induced non-alcoholic fatty liver disease

(2020) Nicole Zeltser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis

(2020) Ayan Mondal et al.   Journal of Neuroinflammation

Dyslipidemic Diet Induces Mobilization of Peripheral Neutrophils and Monocytes That Exacerbate Hemorrhagic Brain Injury and Neuroinflammation

(2020) Xiuping Li et al.   Frontiers in Cellular Neuroscience

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

(2020) Martina Colognesi et al.   Biomedicines

Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany

(2020) Christian Labenz et al.   DIGESTIVE DISEASES AND SCIENCES

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

(2020) Christopher F. Rose et al.   JOURNAL OF HEPATOLOGY

Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatment

(2019) Tiziano Balzano et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease causes dissociated changes in metabolic liver functions

(2019) Peter Lykke Eriksen et al.   Clinics and Research in Hepatology and Gastroenterology

Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies

(2019) Anna Rita Atti et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review

(2019) Rosa Lombardi et al.   DIGESTIVE AND LIVER DISEASE

Neuroinflammation in Murine Cirrhosis is Dependent on the Gut Microbiome and is Attenuated by Fecal Transplant

(2019) Runping Liu et al.   HEPATOLOGY

Non‐Alcoholic Fatty Liver Disease, Liver Fibrosis Score and Cognitive Function in Middle‐Aged Adults: The Framingham Study

(2019) Galit Weinstein et al.   LIVER INTERNATIONAL

Importance of fatigue and its measurement in chronic liver disease

(2019) Lynn H Gerber et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

(2019) Anthony Pinçon et al.   Metabolites

Ammonia scavenging prevents progression of fibrosis in experimental non‐alcoholic fatty liver disease

(2019) Francesco De Chiara et al.   HEPATOLOGY

Non‐alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

(2019) Peter Lykke Eriksen et al.   LIVER INTERNATIONAL

Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits

(2019) Sara G. Higarza et al.   PLoS One

Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases

(2019) Maddalena Grieco et al.   Frontiers in Neuroscience

Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice

(2019) Ekaterina Veniaminova et al.   LIFE SCIENCES

Modulation of hippocampal TLR4/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model

(2019) Safaa K. Mohammed et al.   PHYSIOLOGY & BEHAVIOR

Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis

(2018) Lorena Airaghi et al.   ATHEROSCLEROSIS

Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study

(2018) Antonino Tuttolomondo et al.   Cardiovascular Diabetology

Adipose tissue macrophages and their polarization in health and obesity

(2018) Leen Catrysse et al.   CELLULAR IMMUNOLOGY

Cognitive assessment of patients with nonalcoholic fatty liver disease

(2018) Asuman Celikbilek et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Urea cycle dysregulation in non-alcoholic fatty liver disease

(2018) Francesco De Chiara et al.   JOURNAL OF HEPATOLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Histological Features of Cerebellar Neuropathology in Patients With Alcoholic and Nonalcoholic Steatohepatitis

(2018) Tiziano Balzano et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis

(2018) Karen Louise Thomsen et al.   MEDICAL HYPOTHESES

Cognitive Performance in Individuals with Non-alcoholic Fatty Liver Disease and/or Type 2 Diabetes Mellitus

(2018) Ali A. Weinstein et al.   PSYCHOSOMATICS

Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study

(2018) Galit Weinstein et al.   JAMA Neurology

Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease

(2018) Branka Filipović et al.   Canadian Journal of Gastroenterology and Hepatology

Cerebral Hemodynamics and Vascular Risk Factors: Setting the Stage for Alzheimer's Disease

(2018) Jack C. de la Torre   JOURNAL OF ALZHEIMERS DISEASE

Association of CTRP13 with Liver Enzymes and Cognitive Symptoms in Nonalcoholic Fatty Liver Disease

(2018) Kyungeh An et al.   NURSING RESEARCH

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons

(2018) Tiziano Balzano et al.   Scientific Reports

Liver Fat is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study

(2018) Zachary P. Fricker et al.   Clinical Gastroenterology and Hepatology

Neuroinflammation in the central nervous system: Symphony of glial cells

(2018) Qiao‐qiao Yang et al.   GLIA

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

(2017) Leon A Adams et al.   GUT

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

(2017) Jasmohan S. Bajaj et al.   HEPATOLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Nonalcoholic fatty liver disease and measures of early brain health in middle-aged adults: The CARDIA study

(2017) Lisa B. VanWagner et al.   Obesity

Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment

(2017) Yue Leng et al.   JAMA Neurology

Metabolic liver function in humans measured by 2-18F-fluoro-2-deoxy-D-galactose PET/CT–reproducibility and clinical potential

(2017) Kirstine P. Bak-Fredslund et al.   EJNMMI Research

Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy

(2017) Atsushi Takahashi et al.   PLoS One

The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies

(2016) Emilio Pedditizi et al.   AGE AND AGEING

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

(2016) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

(2016) Do-Geun Kim et al.   Journal of Neuroinflammation

The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease

(2016) Salvatore Petta et al.   MEDICINE

Associations Between Hepatic Functions and Plasma Amyloid-Beta Levels—Implications for the Capacity of Liver in Peripheral Amyloid-Beta Clearance

(2016) Ye-Ran Wang et al.   MOLECULAR NEUROBIOLOGY

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Nonalcoholic fatty liver disease is associated with cognitive function in adults

(2016) Sang Won Seo et al.   NEUROLOGY

The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity

(2016) Peter Benotti et al.   Obesity

Impaired Gut-Liver-Brain Axis in Patients with Cirrhosis

(2016) Vishwadeep Ahluwalia et al.   Scientific Reports

Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia

(2016) Tze Pin Ng et al.   JAMA Neurology

The Immune Landscape in Nonalcoholic Steatohepatitis

(2016) Sowmya Narayanan et al.   Immune Network

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

(2016) Dongsheng Cai et al.   Aging-US

Nonalcoholic Fatty Liver Disease and Vascular Function: Cross-Sectional Analysis in the Framingham Heart Study

(2015) M. T. Long et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

(2015) Jasmohan S. Bajaj et al.   HEPATOLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

(2015) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

Experimental nonalcoholic steatohepatitis compromises ureagenesis, an essential hepatic metabolic function

(2014) Karen Louise Thomsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obesity and neuroinflammation: A pathway to cognitive impairment

(2014) Alyson A. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver

(2014) Hendrik Vilstrup et al.   HEPATOLOGY

Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

(2014) Pierre Bedossa et al.   HEPATOLOGY

Procoagulant imbalance in patients with non-alcoholic fatty liver disease

(2014) Armando Tripodi et al.   JOURNAL OF HEPATOLOGY

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Nonalcoholic fatty liver disease and vascular disease: State-of-the-art

(2014) Silvia Fargion   WORLD JOURNAL OF GASTROENTEROLOGY

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; Should we care?

(2013) Ebenezer T. Oni et al.   ATHEROSCLEROSIS

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

(2013) Maitreyi Raman et al.   Clinical Gastroenterology and Hepatology

Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up

(2013) Chris Elliott et al.   DIGESTIVE DISEASES AND SCIENCES

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic Fatty Liver Disease

(2013) Ding-You Li et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Adult obstructive sleep apnoea

(2013) Amy S Jordan et al.   LANCET

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

The liver–brain axis in liver failure: neuroinflammation and encephalopathy

(2013) Roger F. Butterworth   Nature Reviews Gastroenterology & Hepatology

Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis

(2013) G. Musso et al.   Obesity Reviews

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Memory and Obstructive Sleep Apnea: A Meta-Analysis

(2013) Anna Wallace et al.   SLEEP

Executive Dysfunction in OSA Before and After Treatment: A Meta-Analysis

(2013) Michelle Olaithe et al.   SLEEP

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

(2012) G. Cheng et al.   INTERNAL MEDICINE JOURNAL

Depressive symptoms in older people with metabolic syndrome: is there a relationship with inflammation?

(2012) Giovanni Viscogliosi et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Hypothalamic dysfunction in obesity

(2012) Lynda M. Williams   PROCEEDINGS OF THE NUTRITION SOCIETY

Obstructive Sleep Apnea-Hypopnea Syndrome and Nonalcoholic Fatty Liver Disease: Emerging Evidence and Mechanisms

(2012) Giovanni Musso et al.   SEMINARS IN LIVER DISEASE

Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis

(2012) Yaron Ilan   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatic Steatosis, Obesity, and the Metabolic Syndrome Are Independently and Additively Associated With Increased Systemic Inflammation

(2011) Chiadi E. Ndumele et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik Study

(2011) Gary F. Mitchell et al.   BRAIN

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1)

(2011) Cristina Ionica Øie et al.   JOURNAL OF HEPATOLOGY

Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese

(2011) Judith Aron-Wisnewsky et al.   JOURNAL OF HEPATOLOGY

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

(2011) Vicente Felipo et al.   METABOLIC BRAIN DISEASE

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Systemic Symptoms in Non-Alcoholic Fatty Liver Disease

(2010) Julia L. Newton   DIGESTIVE DISEASES

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

(2010) V. W.-S. Wong et al.   GUT

Association of MRI Markers of Vascular Brain Injury With Incident Stroke, Mild Cognitive Impairment, Dementia, and Mortality

(2010) Stéphanie Debette et al.   STROKE

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Elevation of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver disease

(2009) Chia-Chi Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor  Signaling during Peripheral Organ Inflammation

(2009) C. D'Mello et al.   JOURNAL OF NEUROSCIENCE

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Magnetic Resonance Imaging White Matter Hyperintensities and Brain Volume in the Prediction of Mild Cognitive Impairment and Dementia

(2008) Eric E. Smith et al.   ARCHIVES OF NEUROLOGY

Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver

(2008) Nila Rafiq et al.   Clinical Gastroenterology and Hepatology

Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance

(2008) J L Newton et al.   GUT

Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline

(2008) L. C. Silbert et al.   NEUROLOGY