Journal
OBESITY
Volume 25, Issue 3, Pages 642-651Publisher
WILEY
DOI: 10.1002/oby.21767
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Funding
- National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C, HHSN268201300029C, HHSN268200900041C]
- Intramural Research Program of the National Institute on Aging (NIA)
- intra-agency agreement between NIA and NHLBI [AG0005]
- National Institutes of Health's National Center for Advancing Translational Sciences [KL2TR001424]
- National Institutes of Health [R01-HL-098445, 1ZIAAG007480]
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Objective: To assess associations between nonalcoholic fatty liver disease (NAFLD) and measures of brain health in a population-based sample of adults. Methods: Participants from the CARDIA study (Y25 exam; age 43-55 years) with concurrent computed tomography quantification of liver fat, visceral adipose tissue (VAT), and brain magnetic resonance (MR) images were included (n=505). NAFLD was identified after exclusion of other causes of liver fat. Total tissue volume (TTV) and gray matter cerebral blood flow (GM-CBF) were estimated using 3T brain MR images. Results: NAFLD prevalence was 18%. NAFLD was associated with lower TTV and GM-CBF after adjusting for intracranial volume, demographics, and health behaviors (P< 0.04 for all). In models with additional adjustment for cardiovascular risk factors, the association of NAFLD with GM-CBF remained significant (P=0.04) but was attenuated after adjustment for VAT (P=0.06) and eliminated with BMI (P=0.20). NAFLD was not associated with TTV after adjustment for cardiovascular risk factors (P =0.10) or additional adjustment for VAT ( P=0.14) or BMI (P=0.05). Conclusions: NAFLD is negatively associated with early brain health as assessed by MR measures of structure (TTV) and perfusion (GM-CBF). BMI and VAT attenuated this relationship, providing insight into the potential metabolic role of liver fat in brain health and disease.
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