Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

(2020) Ajit Magadum et al.   CIRCULATION

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

(2020) Jin Wang et al.   Acta Pharmaceutica Sinica B

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: therapeutic efficacy of dihydrotanshinone-I

(2020) Hao Zeng et al.   Acta Pharmaceutica Sinica B

Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI

(2020) Ludger Hauck et al.   CELL DEATH AND DIFFERENTIATION

HIF-1α preconditioning potentiates antioxidant activity in ischemic injury: the role of sequential administration of dihydrotanshinone I and protocatechuic aldehyde in cardioprotection

(2019) Ping Li et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction

(2019) Chen-Yun Chen et al.   EBioMedicine

Pyruvate kinase M2: A simple molecule with complex functions

(2019) Mohammed Alquraishi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming

(2018) Qingran Li et al.   MOLECULAR & CELLULAR PROTEOMICS

Neuroprotective Effects of Phenolic and Carboxylic Acids on Oxidative Stress-Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells

(2018) Naw Hser Gay et al.   NEUROCHEMICAL RESEARCH

Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice

(2018) Dongdong Chen et al.   Neurotherapeutics

HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction

(2018) Allison Lesher Williams et al.   PHYSIOLOGICAL GENOMICS

Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes

(2018) Yong Fan et al.   Stem Cell Research & Therapy

Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition

(2017) Li-Chao Wang et al.   EBioMedicine

Functional Metabolomics Characterizes a Key Role for N -Acetylneuraminic Acid in Coronary Artery Diseases

(2017) Lei Zhang et al.   CIRCULATION

3,3′,5-triiodothyroxine inhibits apoptosis and oxidative stress by the PKM2/PKM1 ratio during oxygen-glucose deprivation/reperfusion AC16 and HCM-a cells

(2016) Qi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

(2016) Dongqing Guo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway

(2016) Chao Guo et al.   MOLECULAR NEUROBIOLOGY

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

(2016) Abhishek Bhardwaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protocatechuic Aldehyde Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Nox-Mediated Oxidative Stress and Renal Inflammation

(2016) Li Gao et al.   Frontiers in Pharmacology

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A PKM2 signature in the failing heart

(2015) Meredith L. Rees et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway

(2015) Ying Ying et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pyruvate kinase isoenzyme M2 expression correlates with survival of cardiomyocytes after allogeneic rat heterotopic heart transplantation

(2015) Jiahai Shi et al.   PATHOLOGY RESEARCH AND PRACTICE

Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk

(2014) Hongtao Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase

(2014) Stanislas Werfel et al.   CARDIOVASCULAR RESEARCH

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells

(2014) Yuhui Jiang et al.   Nature Communications

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

Protocatechuic aldehyde inhibits migration and proliferation of vascular smooth muscle cells and intravascular thrombosis

(2012) Chang Yoon Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Protocatechuic Aldehyde Inhibits Lipopolysaccharide-induced Human Umbilical Vein Endothelial Cell Apoptosis via Regulation of Caspase-3

(2012) Ya-Ling Xing et al.   PHYTOTHERAPY RESEARCH

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulators

(2008) G Roué et al.   ONCOGENE