Organoid microphysiological system preserves pancreatic islet function within 3D matrix

Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

(2020) Mirza Muhammad Fahd Qadir et al.   Nature Communications

The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules

(2019) Miruna Nemecz et al.   Frontiers in Pharmacology

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Oxygenation strategies for encapsulated islet and beta cell transplants

(2019) Klearchos K. Papas et al.   ADVANCED DRUG DELIVERY REVIEWS

Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum

(2019) Iok Teng Kuok et al.   Islets

Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets

(2019) Oscar Alcazar et al.   Frontiers in Endocrinology

In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids

(2019) Yesl Jun et al.   Science Advances

3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture

(2018) K. Jiang et al.   BIOMATERIALS

Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions

(2018) Nathaniel J. Hart et al.   DIABETOLOGIA

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

(2017) Marta Garcia-Contreras et al.   JOURNAL OF PROTEOME RESEARCH

Laminin and collagen IV inclusion in immunoisolating microcapsules reduces cytokine-mediated cell death in human pancreatic islets

(2017) L. Alberto Llacua et al.   Journal of Tissue Engineering and Regenerative Medicine

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

(2017) Giovanni Lenguito et al.   LAB ON A CHIP

The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance

(2017) Maša Skelin Klemen et al.   Islets

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

(2016) Edward A. Phelps et al.   DIABETES

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

(2016) Camillo Ricordi et al.   DIABETES

On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro

(2015) Mi Jang et al.   Biomicrofluidics

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

(2015) Edinson Lucumi Moreno et al.   LAB ON A CHIP

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

Drug discovery through stem cell-based organoid models

(2014) Adrian Ranga et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

(2013) David W. Scharp et al.   ADVANCED DRUG DELIVERY REVIEWS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Influence of In Vitro and In Vivo Oxygen Modulation onβCell Differentiation From Human Embryonic Stem Cells

(2013) Sirlene Cechin et al.   Stem Cells Translational Medicine

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells

(2011) R. Olsson et al.   DIABETES

Whole-Teflon microfluidic chips

(2011) K. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

(2011) Peter Buchwald   Theoretical Biology and Medical Modelling

Microfluidic perifusion and imaging device for multi-parametric islet function assessment

(2010) Adeola F. Adewola et al.   BIOMEDICAL MICRODEVICES

Quantitative Assessment of Islet Cell Products: Estimating the Accuracy of the Existing Protocol and Accounting for Islet Size Distribution

(2010) Peter Buchwald et al.   CELL TRANSPLANTATION

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

(2010) Anna Pisania et al.   LABORATORY INVESTIGATION

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

(2009) John C. Stendahl et al.   CELL TRANSPLANTATION

FEM-based oxygen consumption and cell viability models for avascular pancreatic islets

(2009) Peter Buchwald   Theoretical Biology and Medical Modelling

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

(2009) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Microfluidic device for multimodal characterization of pancreatic islets

(2008) Javeed Shaikh Mohammed et al.   LAB ON A CHIP