DNA Methylation of TLR4, VEGFA, and DEFA5 Is Associated With Necrotizing Enterocolitis in Preterm Infants

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

(2020) Simon Kebede Merid et al.   Genome Medicine

Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

(2020) Misty Good et al.   Clinical Epigenetics

RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease

(2019) Pei Du et al.   Clinical Epigenetics

Advances in Hypoxia-Inducible Factor Biology

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Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility

(2018) E. Cerrillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Comparison of Meconium DNA Extraction Methods for Use in Microbiome Studies

(2018) Lisa F. Stinson et al.   Frontiers in Microbiology

Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis

(2018) Shiloh R. Lueschow et al.   PLoS One

Intestinal microcirculation and necrotizing enterocolitis: The vascular endothelial growth factor system

(2018) Rakhee M. Bowker et al.   Seminars in Fetal & Neonatal Medicine

From population reference to national standard: new and improved birthweight charts

(2018) Liset Hoftiezer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Increased incidence of necrotizing enterocolitis in the Netherlands after implementation of the new Dutch guideline for active treatment in extremely preterm infants: Results from three academic referral centers

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Genetic alterations in necrotizing enterocolitis

(2017) Alain Cuna et al.   SEMINARS IN PERINATOLOGY

A Necrotizing Enterocolitis-Associated Gut Microbiota Is Present in the Meconium: Results of a Prospective Study

(2016) Fardou H. Heida et al.   CLINICAL INFECTIOUS DISEASES

Paneth cells in the developing gut: when do they arise and when are they immune competent?

(2016) Fardou H. Heida et al.   PEDIATRIC RESEARCH

Early Detection of Necrotizing Enterocolitis by Fecal Volatile Organic Compounds Analysis

(2015) Tim G.J. de Meij et al.   JOURNAL OF PEDIATRICS

Intestinal Vascular Endothelial Growth Factor Is Decreased in Necrotizing Enterocolitis

(2015) Animesh Sabnis et al.   Neonatology

Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer

(2015) Tae Woo Kim et al.   Oncotarget

Comparative MiRNA Expressional Profiles and Molecular Networks in Human Small Bowel Tissues of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation

(2015) Pak Cheung Ng et al.   PLoS One

Marked methylation changes in intestinal genes during the perinatal period of preterm neonates

(2014) Fei Gao et al.   BMC GENOMICS

Necrotizing Enterocolitis: The Mystery Goes On

(2014) Josef Neu   Neonatology

Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis

(2014) Di Meng et al.   PEDIATRIC RESEARCH

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Epigenetic Changes in the eNOS Gene

(2013) Leila Kheirandish-Gozal et al.   CHEST

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch

(2013) David J. Hackam et al.   Seminars in Pediatric Surgery

Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia

(2013) Deepali P Sundrani et al.   Clinical Epigenetics

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a–Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity

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Paneth Cells and Necrotizing Enterocolitis: A Novel Hypothesis for Disease Pathogenesis

(2012) Steven J. McElroy et al.   Neonatology

Erythropoietin Protects Intestinal Epithelial Barrier Function and Lowers the Incidence of Experimental Neonatal Necrotizing Enterocolitis

(2011) Sheng-Ru Shiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells

(2011) Kyoko Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live Colonocytes in Newborn Stool: Surrogates for Evaluation of Gut Physiology and Disease Pathogenesis

(2011) Dinesh S Chandel et al.   PEDIATRIC RESEARCH

Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells

(2010) Robert S. Chapkin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products

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Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE