Article
Multidisciplinary Sciences
Mai Kato, Momoka Yamaguchi, Akira Ooka, Ryota Takahashi, Takuji Suzuki, Keita Onoda, Yuko Yoshikawa, Yuta Tsunematsu, Michio Sato, Yasukiyo Yoshioka, Miki Igarashi, Sumio Hayakawa, Kumiko Shoji, Yutaka Shoji, Tomohisa Ishikawa, Kenji Watanabe, Noriyuki Miyoshi
Summary: The increased incidence of obesity has led to an increase in chronic inflammation-related diseases such as NASH-HCC. Fecal VOCs, particularly diacetyl, have been identified as potential biomarkers for NASH-HCC. Diacetyl induces inflammation and fibrosis in mouse macrophage and liver cells, suggesting its contribution to the pathogenesis of NASH-HCC.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Brian D. Hosfield, Natalie A. Drucker, Anthony R. Pecoraro, William C. Shelley, Hongge Li, Nielson T. Baxter, Troy B. Hawkins, Troy A. Markel
Summary: Experimental NEC in mice resulted in severe intestinal injury, decreased microbial diversity, and dysbiosis in the gut microbiome. Additionally, fecal VOC analysis was able to distinguish NEC pups from control groups, suggesting potential for VOCs to be used as a biomarker for diagnosing NEC.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Dominique Grandjean, Caroline Elie, Capucine Gallet, Clotilde Julien, Vinciane Roger, Loic Desquilbet, Guillaume Alvergnat, Severine Delarue, Audrey Gabassi, Marine Minier, Laure Choupeaux, Solen Kerneis, Constance Delaugerre, Jerome Le Goff, Jean-Marc Treluyer
Summary: The study evaluates the diagnostic accuracy of canine olfaction in non-invasive detection of SARS-CoV-2 infection. The results show that canine detection has a high sensitivity and can be used as an alternative method in mass screening.
Article
Ecology
Anders Brunse, Ling Deng, Xiaoyu Pan, Yan Hui, Josue L. Castro-Mejia, Witold Kot, Duc Ninh Nguyen, Jan Bojsen-Moller Secher, Dennis Sandris Nielsen, Thomas Thymann
Summary: This study demonstrated that fecal filtrate transplantation (FFT) is more effective in preventing NEC compared to fecal microbiota transplantation (FMT), without any recognizable side effects. Oro-gastric FFT completely prevented NEC, increased viral diversity, and reduced the relative abundance of specific bacteria phylum in the ileal mucosa.
Review
Medical Laboratory Technology
Ting Chen, Tiannan Liu, Ting Li, Hang Zhao, Qianming Chen
Summary: The review introduces the conventional and emerging methods for breath analysis in diagnosing and monitoring various diseases. It discusses the correlation between breath components and specific diseases, as well as unique ideas and devices for the diagnosis of common diseases through exhaled breath analysis. The potential application of exhaled breath analysis for diagnosing and screening different diseases is briefly introduced, offering a new avenue for non-invasive disease detection.
CLINICA CHIMICA ACTA
(2021)
Review
Pediatrics
Ramaa Chitale, Kacey Ferguson, Megan Talej, Wen-Chien Yang, Siran He, Karen M. Edmond, Emily R. Smith
Summary: Early enteral feeding within 72 hours after birth is likely to reduce mortality and length of hospital stay in preterm and low birth weight infants, and may also decrease the risk of sepsis and weight at discharge. However, its effect on other outcomes such as necrotizing enterocolitis is uncertain.
Article
Food Science & Technology
Ana Martinez, Alejandro Hernandez, Carlos Moraga, Paula Tejero, Maria de Guia Cordoba, Alberto Martin
Summary: The aim of this study was to investigate the changes in volatile organic compounds (VOCs) in 'Golden Delicious' apples caused by mechanical damage. Direct extraction and CAR/PDMS fiber were proposed as the best methods for identifying VOCs associated with mechanical damage. The study found that the mechanical damage resulted in changes in ester compounds in the apples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pediatrics
Roberta Vitali, Gianluca Terrin, Francesca Palone, Ilaria Laudadio, Salvatore Cucchiara, Giovanni Boscarino, Maria Di Chiara, Laura Stronati
Summary: This study demonstrated that fecal HMGB1 could be a reliable marker for early identification of necrotizing enterocolitis (NEC) risk in preterm neonates. Further investigation and studies are needed to evaluate the diagnostic accuracy of this marker in managing preterm newborns at risk of NEC, especially in more severe forms of the disease.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Antonio Murgia, Yusuf Ahmed, Kelly Sweeney, Louise Nicholson-Scott, Kayleigh Arthur, Max Allsworth, Billy Boyle, Olga Gandelman, Agnieszka Smolinska, Giuseppe Ferrandino
Summary: The gold standard method for diagnosing and staging chronic liver diseases is liver biopsy, although breath analysis represents an attractive non-invasive alternative. Studies comparing breath samples of patients with chronic liver diseases to control subjects have identified candidate biomarkers, with the most effective compounds being of exogenous origin. The use of an exogenous volatile organic compounds (EVOCs) probe approach may help overcome the limitations of random dietary exposure and has shown potential in healthy subjects.
Article
Chemistry, Physical
Maedeh Mashhadbani, Edris Faizabadi
Summary: In this study, armchair stanene nanoribbons were analyzed as excellent sensing substances for early lung cancer diagnosis. Modified configurations of surface- and edge-defected nanoribbons were studied to improve sensing performance. The results showed that armchair stanene nanoribbons have at least five times greater adsorption energy than other reported substances, such as carbon nanotubes, phosphorene, and silicene. The sensitivity and selectivity of the system were found to be improved by configurations with single vacancy and edge defects.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Surgery
K. F. H. Hintzen, J. Grote, A. G. W. E. Wintjens, T. Lubbers, M. M. M. Eussen, F. J. van Schooten, N. D. Bouvy, A. Peeters
Summary: This review aimed to evaluate the diagnostic accuracy and current status of VOC analysis in exhaled breath for the detection of cancer in the digestive tract. The sensitivity and specificity of VOC analysis ranged from 66.7% to 100% and from 48.1% to 97.9% respectively, with 32 VOCs identified in more than one study. However, there is a lack of standardization in study designs, heterogeneity between the studies, and insufficient validation of the results.
Article
Chemistry, Applied
Guozheng Wei, Meiling Dan, Guohua Zhao, Damao Wang
Summary: Food flavor plays a crucial role in food consumption, production, and scientific research. Chromatography-mass spectrometry and electronic nose are the two commonly used technologies for food flavor detection. Chromatography-mass spectrometry has good qualitative and quantitative effects with a wide detection range, while electronic nose is convenient and fast for practical applications. This paper reviews the principles, advantages, disadvantages, research progress, and application of these two methods and their derived analytical techniques in flavor fingerprinting. It discusses the application scenarios and advantages of combining different technologies by summarizing studies reflecting the differences between them. Finally, it discusses the current challenges and future directions of food flavor detection technology.
Article
Chemistry, Analytical
Jingfeng Weng, Junzhe Zhang, Chunyu Zhang, Jin Lv, Jinhui Liu, Chengqian Zhou, Jun Yuan, Min Wang, Dongqing Xu, Yun Zhong, Wenli Chen
Summary: In this study, a PEI/CNT-COOH gas sensor was designed to diagnose citrus Huanglongbing by detecting VOCs. Compared with conventional methods, this sensor has higher accuracy and portability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Multidisciplinary Sciences
Qi Liu, Yingjing Fan, Shunjie Zeng, Yuxiao Zhao, Longchen Yu, Liqiang Zhao, Jingxian Gao, Xin Zhang, Yi Zhang
Summary: This study evaluates the potential of urine volatile organic compounds (VOCs) as a novel diagnostic biomarker for prostate cancer (PCa). Gas chromatography-ion mobility spectrometry (GC-IMS) was used to detect VOCs in urine samples from PCa patients and non-cancerous controls. Machine learning algorithms were employed to effectively facilitate PCa diagnosis, resulting in the construction of diagnostic models based on four selected VOCs with high AUC values.
Article
Chemistry, Analytical
Hao Lin, Fuyun Wang, Yaxian Duan, Wencui Kang, Quansheng Chen, Zhaoli Xue
Summary: This study presents an effective method for early detection of Aspergillus infections in wheat using porous silica nanospheres to fabricate nanocomposite colorimetric sensors. The results show that the nanocomposite colorimetric sensor can improve the chemical response of Aspergillus infected wheat in the early stage and mild infections, accurately distinguishing infected wheat samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Filip Cools, Andre Kroon, Marja van der Heide-jalving, Peter Dijk, Henrica L. M. van Straaten, Arjan B. te Pas, Thilo Mohns, Els Bruneel, Arno F. J. van Heijst, Boris Kramer, Anne Debeer, Inge A. Zonnenberg, Yoann Marechal, Henry Blom, Katleen Plaskie, Maruschka P. Merkus, Martin Offringa, Anton H. van Kaam
Summary: In preterm infants, early use of systemic hydrocortisone improves pulmonary condition, facilitates weaning from invasive ventilation, and has mild effects on blood glucose levels and blood pressure.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Koen P. P. Dijkman, Tom G. G. Goos, Jeanne P. P. Dieleman, Thilo Mohns, Carola van Pul, Peter Andriessen, Andre A. Kroon, Irwin K. K. Reiss, Hendrik J. J. Niemarkt
Summary: This study investigated the feasibility of closed loop FiO(2) control by PRICO in maintaining SpO2 within a target range in preterm infants on different modes of respiratory support. The findings suggest that PRICO is superior to routine manual control in maintaining SpO2 within target ranges.
Review
Chemistry, Analytical
Ashwin Krishnamoorthy, Subashini Chandrapalan, Sofie Bosch, Ayman Bannaga, Nanne K. H. De Boer, Tim G. J. De Meij, Marcis Leja, George B. Hanna, Nicoletta De Vietro, Donato Altomare, Ramesh P. Arasaradnam
Summary: This paper aims to investigate the impact of mechanical bowel preparation on the production and measurement of volatile organic compounds (VOCs) by conducting a systematic search. The findings suggest that mechanical bowel preparation does not affect VOC profiles in breath, but it does alter urinary VOC profiles.
Article
Computer Science, Information Systems
Zheng Peng, Gabriele Varisco, Xi Long, Rong-Hao Liang, Deedee Kommers, Ward Cottaar, Peter Andriessen, Carola van Pul
Summary: The aim of this study is to develop a explainable late-onset sepsis (LOS) prediction algorithm using continuous multi-channel physiological signals. Features from different signal channels (HRV, respiration, and motion) were extracted and fed into machine learning classifiers. The best performance was achieved by an extreme gradient boosting classifier combining features from all signal channels, with an AUC of 0.88.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Gastroenterology & Hepatology
J. E. Kreijne, R. L. Goetgebuer, N. S. Erler, N. K. De Boer, A. G. Siebers, G. Dijkstra, F. A. van Kemenade, F. Hoentjen, B. Oldenburg, A. E. van der Meulen, C. I. J. Ponsioen, M. J. Pierik, C. J. van der Woude, A. C. de Vries
Summary: This study found that women with inflammatory bowel disease (IBD) are at increased risk of high-grade cervical intraepithelial neoplasia and cervical cancer (CIN2+). The risk of CIN2+ increases with longer cumulative exposure to immunomodulators (IM), but no association was found with cumulative exposure to biologic agents (BIO) or both BIO and IM.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Infectious Diseases
Sanne J. M. Zilver, Christianne J. M. de Groot, Marloes Grobben, Sharon Remmelzwaal, Esmee Burgers, Daniela Nunez Velasco, Hannah G. Juncker, Britt J. van Keulen, Johannes B. van Goudoever, Robert A. de Leeuw, Marit J. van Gils, Carrie Ris-Stalpers, Elisabeth van Leeuwen
Summary: This study aimed to determine the optimal timing of COVID-19 vaccination to protect pregnant women and neonates. The results suggest that vaccination in early second trimester is advised for the optimum balance between maternal and placental antibody transfer to the neonate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Thomas Dierikx, Andries Budding, Martine Bos, Henriette van Laerhoven, Sophie van der Schoor, Hendrik Niemarkt, Marc Benninga, Anton van Kaam, Douwe Visser, Tim de Meij
Summary: This study evaluated the potential of the rapid Molecular Culture (MC) assay for early onset neonatal sepsis (EOS) diagnosis. MC was able to detect bacteria even when the bacterial load was low. The majority of MC results were comparable with PBC results and the risk for contamination and false positive results was limited. Therefore, MC has the potential to replace conventional PBC in EOS diagnostics.
Article
Microbiology
Nina M. Frerichs, Sofia el Manouni el Hassani, Nancy Deianova, Mirjam M. van Weissenbruch, Anton H. van Kaam, Daniel C. Vijlbrief, Johannes B. van Goudoever, Christian V. Hulzebos, Boris. W. Kramer, Esther J. d'Haens, Veerle Cossey, Willem P. de Boode, Wouter J. de Jonge, Alfian N. Wicaksono, James A. Covington, Marc A. Benninga, Nanne K. H. de Boer, Hendrik J. Niemarkt, Tim G. J. de Meij
Summary: Early detection of late-onset sepsis (LOS) in preterm infants is essential. Fecal volatile organic compounds (VOCs) can serve as a non-invasive biomarker for detecting LOS. The study analyzed fecal samples of LOS infants and matched controls using gas chromatography-ion mobility spectrometry and gas chromatography-time of flight-mass spectrometry. Differences in VOCs were found before the onset of Escherichia coli LOS and gram-negative LOS. This study highlights the potential of VOCs as a non-invasive preclinical diagnostic biomarker for LOS.
Article
Infectious Diseases
Nancy Deianova, Nanne K. de Boer, Hafsa Aoulad Ahajan, Cilla Verbeek, Cornelieke S. H. Aarnoudse-Moens, Aleid G. Leemhuis, Mirjam M. van Weissenbruch, Anton H. van Kaam, Daniel C. Vijbrief, Chris V. Hulzebos, Astrid Giezen, Veerle Cossey, Willem P. de Boode, Wouter J. de Jonge, Marc A. Benninga, Hendrik J. Niemarkt, Tim G. J. de Meij
Summary: Over 90% of preterm neonates are exposed to antibiotics as a potentially life-saving measure. However, there is insufficient research on the long-term outcomes associated with antibiotic exposure after preterm birth. This study investigated the relationship between duration of antibiotic exposure and developmental and health outcomes in preterm-born children, as well as the impact of gestational age (GA) on outcomes.
Article
Pediatrics
Anouk W. J. Scholten, Zhuozhao Zhan, Hendrik J. Niemarkt, Marieke Vervoorn, Ruud W. van Leuteren, Frans H. de Jongh, Anton H. van Kaam, Edwin R. van den Heuvel, Gerard J. Hutten
Summary: This study demonstrates that the wireless and nonadhesive belt performs similarly to standard electrocardiography (ECG) in monitoring heart rate (HR), and has a moderate agreement in respiratory rate (RR) trend compared to chest impedance (CI).
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Richelle A. C. M. Olde Keizer, Abderrahim Marouane, Wilhelmina Kerstjens-Frederikse, A. Chantal Deden, Klaske Lichtenbelt, Tinneke Jonckers, Marieke Vervoorn, Maaike Vreeburg, Lidewij Henneman, Linda de Vries, Richard Sinke, Rolph Pfundt, Servi J. C. Stevens, Peter Andriessen, Richard van Lingen, Marcel Nelen, Hans Scheffer, Daphne Stemkens, Cor Oosterwijk, Hans Kristian Ploos van Amstel, Willem de Boode, Wendy A. G. van Zelst-Stams, Geert W. J. Frederix, Lisenka E. L. M. Vissers
Summary: The introduction of rapid exome sequencing (rES) has improved clinical decision-making for critically ill neonates. A clinical utility study was conducted comparing rES to routine genetic testing, and the results showed that rES detected more conclusive genetic diagnoses in shorter time and reduced genetic diagnostic costs.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Dandan Zhang, Zheng Peng, Carola Van Pul, Sebastiaan Overeem, Wei Chen, Jeroen Dudink, Peter Andriessen, Ronald M. Aarts, Xi Long
Summary: This study explores the effectiveness of incorporating video-based actigraphy analysis alongside cardiorespiratory signals for classifying the sleep states of preterm infants. The results suggest that combining video-based actigraphy with cardiorespiratory signals can potentially enhance the performance of sleep-state classification.
Article
Biophysics
R. M. J. S. Kloonen, G. Varisco, E. de Kort, P. Andriessen, H. J. Niemarkt, C. van Pul
Summary: The aim of this study was to predict CPAP-F after LISA by analyzing high resolution vital parameter monitoring data surrounding the LISA procedure using machine learning.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)