Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

(2020) Jianxin Huo et al.   Cells

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

(2020) Nadia S. Kurd et al.   Science Immunology

Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3

(2020) Livia Odagiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

(2019) Xindong Liu et al.   NATURE

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Nr4a Receptors Enhances Antitumor Immunity by Breaking Treg-Mediated Immune Tolerance

(2018) Sana Hibino et al.   CANCER RESEARCH

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis -Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation

(2018) Dapeng Wang et al.   IMMUNITY

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

T cell cytolytic capacity is independent of initial stimulation strength

(2018) Arianne C. Richard et al.   NATURE IMMUNOLOGY

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity

(2018) Marie Liebmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells

(2018) Takashi Sekiya et al.   Cell Reports

Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells

(2017) Qian Nancy Hu et al.   JOURNAL OF IMMUNOLOGY

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Exhaustion-associated regulatory regions in CD8+tumor-infiltrating T cells

(2017) Giuliana P. Mognol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells

(2017) Darienne R. Myers et al.   Cell Reports

Transcriptional modulation of regulatory T cell development by novel regulators NR4As

(2016) Hee Yeon Won et al.   ARCHIVES OF PHARMACAL RESEARCH

Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes

(2016) S Oh et al.   CELL DEATH AND DIFFERENTIATION

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection

(2016) James P. Scott-Browne et al.   IMMUNITY

Roles of regulatory T cells in cancer immunity

(2016) Yoshiko Takeuchi et al.   INTERNATIONAL IMMUNOLOGY

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells

(2016) Judith F. Ashouri et al.   JOURNAL OF IMMUNOLOGY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance

(2015) Hiroyuki Takaba et al.   CELL

Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion

(2015) M. Giordano et al.   EMBO JOURNAL

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells

(2015) Weiwei Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+T Cell Expansion and Effector Function through Direct Repression of Irf4

(2015) Heba N. Nowyhed et al.   JOURNAL OF IMMUNOLOGY

Differential Roles for Bim and Nur77 in Thymocyte Clonal Deletion Induced by Ubiquitous Self-Antigen

(2015) Qian Nancy Hu et al.   JOURNAL OF IMMUNOLOGY

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

(2015) C E Forristal et al.   LEUKEMIA

The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

(2015) Heba N. Nowyhed et al.   Scientific Reports

IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV

(2014) M Grusdat et al.   CELL DEATH AND DIFFERENTIATION

Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection

(2014) R. Nayar et al.   JOURNAL OF IMMUNOLOGY

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

(2014) Kristin A Hogquist et al.   NATURE IMMUNOLOGY

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

(2013) Takashi Sekiya et al.   NATURE IMMUNOLOGY

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

(2013) J Adam Best et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells

(2013) F. Raczkowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance

(2012) Herbert G Kasler et al.   EMBO JOURNAL

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

(2012) Daniel H.D. Gray et al.   IMMUNITY

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

(2012) M. S. Fassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Cell Tolerance: Central and Peripheral

(2012) Y. Xing et al.   Cold Spring Harbor Perspectives in Biology

Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation

(2011) Yumiko Yoshioka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells

(2011) R. J. Martinez et al.   JOURNAL OF IMMUNOLOGY

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

(2011) Takashi Sekiya et al.   Nature Communications

Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis

(2010) Jennifer Thompson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fas Apoptosis Inhibitory Molecule Regulates T Cell Receptor-mediated Apoptosis of Thymocytes by Modulating Akt Activation and Nur77 Expression

(2010) Jianxin Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Phosphorylation of Nur77 by the MEK-ERK-RSK Cascade Induces Mitochondrial Translocation and Apoptosis in T Cells

(2009) A. Wang et al.   JOURNAL OF IMMUNOLOGY

Non-redundant function of the MEK5–ERK5 pathway in thymocyte apoptosis

(2008) Sue J Sohn et al.   EMBO JOURNAL

The role of the PI3K-AKT kinase pathway in T-cell development beyond the β checkpoint

(2008) Ling Xue et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ERK5 is involved in TCR-induced apoptosis through the modification of Nur77

(2008) Yasushi Fujii et al.   GENES TO CELLS

Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory

(2008) Matthew A. Williams et al.   IMMUNITY

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

(2008) Jennifer Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Orphan Nuclear Receptor NOR-1 Enhances 3′,5′-Cyclic Adenosine 5′-Monophosphate-Dependent Uncoupling Protein-1 Gene Transcription

(2008) Naresh Kumar et al.   MOLECULAR ENDOCRINOLOGY

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

(2008) Y. Doi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA