Article
Multidisciplinary Sciences
Claire E. Depew, Jordan A. Rixon, Stephen J. McSorley
Summary: Hepatic CD4 tissue-resident memory T cells (TRM) are crucial for protection against Salmonella infection, and a study has found that local inflammation in the liver enhances the formation of CD4 TRM. The researchers developed a system to directly visualize the formation of hepatic TRM and found that liver inflammation also boosts the effectiveness of a subunit Salmonella vaccine. Surprisingly, IL-2 and IL-1 were found to play a role in enhancing CD4 TRM formation. This knowledge is important for developing a more effective vaccine against invasive nontyphoidal salmonellosis (iNTS).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Chunfeng Xu, Mingjie Wang, Behrouz Zandieh-Doulabi, Wei Sun, Lingfei Wei, Yuelian Liu
Summary: BMP-2, while potentially useful in repairing bone defects after OS resection, has limited application due to concerns about its tumorigenicity. Studies are focusing on understanding the impact of BMSCs' response to BMP-2 on OS development to pave the way for safer and broader clinical use of BMP-2 in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Dejan Mamula, Shervin Khosousi, Yachao He, Vesna Lazarevic, Per Svenningsson
Summary: Dysfunctions in the immune system are associated with both disease onset and progression of Parkinson's disease (PD). This study reveals impaired migration ability, altered mitochondrial positioning, and reduced functionality of CD4(+) T cells in PD patients. Additionally, differential increase of p11 levels in CD4(+) T cell subsets was observed.
NPJ PARKINSONS DISEASE
(2022)
Article
Microbiology
Zhengguo Xiao, Anmol Kandel, Lei Li
Summary: The synergy of neutrophils and IL-12 can enhance the activation of bovine CD4+ T cells, leading to increased CD25 expression and IFN-gamma production.
Article
Immunology
Sandra Hellberg, Johanna Raffetseder, Olof Rundquist, Rasmus Magnusson, Georgia Papapavlou, Maria C. Jenmalm, Jan Ernerudh, Mika Gustafsson
Summary: The changes in progesterone levels during and after pregnancy influence the course of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis, possibly through immune-endocrine interactions. Study findings indicate that P4 significantly suppresses CD4(+) T cell activation, impacting gene and protein expression profiles and showing potential for regulating immune responses. These results suggest a role for P4 in immune modulation during pregnancy and highlight the importance of further research on its potential as a treatment option for pregnancy-induced diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Urmi Roy, Romulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Summary: The study reveals that segmented filamentous bacteria (SFB) not only induce Th17 cells but also distinct IL-17A negative CD4+ T cell populations in the intestine, some of which produce IL-22 upon restimulation and during enteric infections. These cells, presumably Th22 cells, develop independently of intestinal Th17 cells and produce a different set of cytokines compared to Th17 cells. This suggests that aside from Th17, SFB can also induce CD4+ T cell populations that serve as an immediate source of IL-22 during intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Simone Sandoval, Keegan Malany, Krista Thongphanh, Clarisa A. Martinez, Michael L. Goodson, Felipe Da Costa Souza, Lo-Wei Lin, Nicolle Sweeney, Jamie Pennington, Pamela J. Lein, Nancy I. Kerkvliet, Allison K. Ehrlich
Summary: Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4(+) T cells, has been found to be highly expressed on activated effector T cells and may be involved in the identification and function of immunopathologic T cells. The downregulation of Nrp1 on CD4(+) T cells is influenced by AhR activation and IL-2. These findings suggest that Nrp1 is an activation marker for CD4(+) T cells and may play a role in AhR-mediated modulation of effector CD4(+) T cell responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
You-Young Jo, HaeYong Kweon, Dae-Won Kim, Kyunghwa Baek, Weon-Sik Chae, Yei-Jin Kang, Ji-Hyeon Oh, Seong-Gon Kim, Umberto Garagiola
Summary: The results showed that silk sericin with a higher molecular weight fraction and more abundant beta-sheet structure increased BMP-2/4 expression and bone formation better in both cell and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Brooks Hopkins, Justin Fisher, Meiping Chang, Xiaoyan Tang, Zhimei Du, William J. Kelly, Zuyi Huang
Summary: This study conducted experiments on the growth of different T cell subsets under different combinations of IL-2, IL-7, and IL-15, developed mathematical models to predict optimal growth conditions, and analyzed RNA sequencing data to study gene networks influencing growth pathways.
Article
Oncology
David B. Rosen, Anne Mansson Kvarnhammar, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Enping Hong, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zuniga, Kathy Bang, Simran Singh Sabharwal, Karan Uppal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Diana Reich, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M. Singel, Kennett Sprogoe, Juha Punnonen
Summary: Recombinant interleukin-2 (IL-2) is an approved cancer immunotherapy, but it has severe toxicities and suboptimal pharmacokinetics. TransCon IL-2 beta/gamma is a novel prodrug designed to address these issues, showing sustained release of IL-2 and potential antitumor activity in animal models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Priyadharshini Devarajan, Allen M. Vong, Catherine H. Castonguay, Noah J. Silverstein, Olivia Kugler-Umana, Bianca L. Bautista, Karen A. Kelly, Jeremy Luban, Susan L. Swain
Summary: Influenza A virus infection drives non-cytotoxic CD4 effector cells to differentiate into lung tissue-resident cytotoxic CD4 effectors, which require recognition of antigen on antigen-presenting cells (APCs) and signals induced by the ongoing infection. Type I interferon and interleukin-15 play important roles in this differentiation process.
Article
Immunology
Helena Nunes-Cabaco, Andreia Ramalho-dos-Santos, Ana R. Pires, Leila R. Martins, Joao T. Barata, Ana E. Sousa
Summary: IL-4 plays a role in the regulation of human thymocyte plasticity and is involved in the generation of CD8+ T cells in the thymus. IL-4 also has implications in neonatal immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi
Summary: A study examined the role of IL-17A and its receptors in HSV-1-induced CNS demyelination. The results showed that IL-17A, along with IL-17RA, IL-17RC, and IL-17RD, plays an important role in this process. Both T cells and non-T cells expressing IL-17A contribute to the development of demyelination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Dimitrios Gkiliopoulos, Ioannis Tsamesidis, Anna Theocharidou, Georgia K. Pouroutzidou, Evi Christodoulou, Evangelia Stalika, Konstantinos Xanthopoulos, Dimitrios Bikiaris, Konstantinos Triantafyllidis, Eleana Kontonasaki
Summary: The study successfully synthesized SBA-15 mesoporous silica materials with varying porosity and evaluated their biocompatibility with hPDLCs, as well as their effectiveness as carriers of rh-BMP-2. Results indicated that SBA-15 MSNs may play a significant role in the effective release of bone-inducing proteins.
Article
Biochemistry & Molecular Biology
David Bending, Alina Paduraru, Catherine B. Ducker, Paz Prieto Martin, Tessa Crompton, Masahiro Ono
Article
Cell Biology
David Bending, Paz Prieto Martin, Alina Paduraru, Catherine Ducker, Erik Marzaganov, Marie Laviron, Satsuki Kitano, Hitoshi Miyachi, Tessa Crompton, Masahiro Ono
JOURNAL OF CELL BIOLOGY
(2018)
Article
Immunology
Alla Bradley, Tetsuo Hashimoto, Masahiro Ono
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Immunology
D. Bending, M. Ono
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Article
Immunology
Diana C. Yanez, Hemant Sahni, Susan Ross, Anisha Solanki, Ching-In Lau, Eleftheria Papaioannou, Alessandro Barbarulo, Rebecca Powell, Ulrike C. Lange, David J. Adams, Martino Barenco, Masahiro Ono, Fulvio D'Acquisto, Anna L. Furmanski, Tessa Crompton
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
Eleftheria Papaioannou, Diana C. Yanez, Susan Ross, Ching-In Lau, Anisha Solanki, Mira Manilal Chawda, Alex Virasami, Ismael Ranz, Masahiro Ono, Ryan F. L. O'Shaughnessy, Tessa Crompton
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Immunology
Konstantinos Mengrelis, Ching-In Lau, Jasmine Rowell, Anisha Solanki, Sonia Norris, Susan Ross, Masahiro Ono, Susan Outram, Tessa Crompton
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Immunology
Masahiro Ono
Article
Immunology
Bahire Kalfaoglu, Jose Almeida-Santos, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono
FRONTIERS IN IMMUNOLOGY
(2020)
Editorial Material
Immunology
Masahiro Ono
Summary: Autoimmune inflammation leads to defective regulatory T cell functions, but inducing Foxp3 expression in these cells during inflammation can restore control over pathogenic T cell functions and resolve inflammation and pathology in mice.
Article
Immunology
Alice Hamilton, Raffaella Rizzo, Samuel Brod, Masahiro Ono, Mauro Perretti, Dianne Cooper, Fulvio D'Acquisto
Summary: Social isolation has a significant impact on the immune regulation of mice, enhancing their resistance to bacterial infection. Social housing and huddling behavior may be important factors in regulating the host immune response.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Hajime Abe, Yohei Tanada, Shigemiki Omiya, Mihai-Nicolae Podaru, Tomokazu Murakawa, Jumpei Ito, Ajay M. Shah, Simon J. Conway, Masahiro Ono, Kinya Otsu
Summary: This study demonstrates that a subset of mouse cardiac fibroblasts become activated by pressure overload and recruit inflammatory Ly6C(hi) monocytes to the heart. The involvement of NF-kappa B in activated cardiac fibroblasts attenuates heart function damage and offers new insights into potential therapeutic strategies for heart failure.
Article
Immunology
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y. F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Summary: The study reveals the contextual influence of IL-2 function and its effects on different cell circuits. Targeted IL-2 production has the potential to fine-tune therapeutic responses, based on the desired clinical outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Correction
Immunology
Carly E. E. Whyte, Kailash Singh, Oliver T. T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y. F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bahire Kalfaoglu, Jose Almeida-Santos, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono
Summary: Research indicates that T-cells play crucial roles in the immunity to COVID-19, with dysregulation noted in severe cases. The impairment of FOXP3 induction in CD4(+) T-cells may lead to abnormal T-cell responses, while hyperactivated T-cells could potentially contribute to dysregulation and tissue destruction in severe COVID-19 patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)