Development and Testing of Thrombolytics in Stroke

Intrinsic Biotaxi Solution Based on Blood Cell Membrane Cloaking Enables Fullerenol Thrombolysis In Vivo

(2020) Kui Chen et al.   ACS Applied Materials & Interfaces

Short‐Term Cessation of Dabigatran Causes a Paradoxical Prothrombotic State

(2020) Jiwon Kim et al.   ANNALS OF NEUROLOGY

Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke

(2019) Zhihua Si et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparison of expression optimization of new derivative of staphylokinase (SAK‐2RGD‐TTI) with the rSAK

(2019) Habibollah Faraji et al.   BIOTECHNOLOGY PROGRESS

In-vitro assessment of the thrombolytic efficacy of therapeutic ultrasound

(2019) Nava Salman-Kesner et al.   THROMBOSIS RESEARCH

Purification and characterization of a novel, highly potent fibrinolytic enzyme from Bacillus subtilis DC27 screened from Douchi, a traditional Chinese fermented soybean food

(2019) Yuanliang Hu et al.   Scientific Reports

tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?

(2019) Jong S. Kim   Journal of Stroke

Polyacrylic acid-coated nanoparticles loaded with recombinant tissue plasminogen activator for the treatment of mice with ischemic stroke

(2019) Lijie Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shear-induced platelet aggregation: 3D-grayscale microfluidics for repeatable and localized occlusive thrombosis

(2019) Michael T. Griffin et al.   Biomicrofluidics

Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke

(2019) Rais Reskiawan A. Kadir et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Evidence that Tenecteplase Is Noninferior to Alteplase for Acute Ischemic Stroke

(2019) Adrian M. Burgos et al.   STROKE

Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities

(2019) Zahraa S. Al-Ahmady et al.   ACS Nano

Liposomes for drug delivery in stroke

(2019) Gisele E. Bruch et al.   BRAIN RESEARCH BULLETIN

Thrombolysis with rhPro-UK 3 to 6 hours after embolic stroke in rat

(2019) Chun-Hua Hao et al.   NEUROLOGICAL RESEARCH

Engineered Nanoplatelets for Targeted Delivery of Plasminogen Activators to Reverse Thrombus in Multiple Mouse Thrombosis Models

(2019) Junchao Xu et al.   ADVANCED MATERIALS

Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases

(2019) Subhathirai Subramaniyan Parimalam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial Cell Activation in an Embolic Ischemia-Reperfusion Injury Microfluidic Model

(2019) Danielle Nemcovsky Amar et al.   Micromachines

Cyclic RGD functionalized liposomes encapsulating urokinase for thrombolysis

(2018) Nengpan Zhang et al.   Acta Biomaterialia

Dose–response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke

(2018) Tauheed Ishrat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vitro thrombolytic activity of a purified fibrinolytic enzyme from Chlorella vulgaris

(2018) Páblo Eugênio da Costa e Silva et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A Novel Thrombolytic and Anticoagulant Serine Protease from Polychaeta, Diopatra sugokai

(2018) Hye Jin Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Regulation of plasminogen activation on cell surfaces and fibrin

(2018) T. Urano et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Efficacy of urokinase lock to treat thrombotic dysfunction of tunneled hemodialysis catheters: A retrospective cohort study

(2018) Freya Van Hulle et al.   Journal of Vascular Access

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

(2018) Bruce C.V. Campbell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

(2018) Gregory W. Albers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Taurine Reduces tPA (Tissue-Type Plasminogen Activator)-Induced Hemorrhage and Microvascular Thrombosis After Embolic Stroke in Rat

(2018) Rong Jin et al.   STROKE

Tenecteplase Knocking on the Door

(2018) Michael D. Hill et al.   STROKE

Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization

(2018) Pavel Vanacek et al.   ACS Catalysis

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform

(2018) V. van Duinen et al.   ANGIOGENESIS

Tenecteplase for the treatment of acute ischemic stroke: A review of completed and ongoing randomized controlled trials

(2018) Shelagh B Coutts et al.   International Journal of Stroke

Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke

(2018) Bijoy K. Menon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Engineering of deglycosylated and plasmin resistant variants of recombinant streptokinase in Pichia pastoris

(2018) Adivitiya et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Single-cell, high-throughput analysis of cell docking to vessel wall

(2018) Anna Andrzejewska et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond

(2018) Audrey M Thiebaut et al.   LANCET NEUROLOGY

Stenotrophomonas maltophilia Gd2: A potential and novel isolate for fibrinolytic enzyme production

(2018) Parag S. Khursade et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Selective middle cerebral artery occlusion in the rabbit: Technique and characterization with pathologic findings and multimodal MRI

(2018) Reza Jahan et al.   JOURNAL OF NEUROSCIENCE METHODS

Demonstration of therapeutic window of Cerebrolysin in embolic stroke: A prospective, randomized, blinded, and placebo-controlled study

(2017) Li Zhang et al.   International Journal of Stroke

Optimized tPA: A non-neurotoxic fibrinolytic agent for the drainage of intracerebral hemorrhages

(2017) Romain Goulay et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Review of Protocols Used in Ultrasound Thrombolysis

(2017) Nicos Papadopoulos et al.   Journal of Stroke & Cerebrovascular Diseases

Fibrinolysis: from blood to the brain

(2017) R. L. Medcalf   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

An In Vitro Assay for Sonothrombolysis Based on the Spectrophotometric Measurement of Clot Thickness

(2017) Zuojun Wang et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

(2017) Pedro F. Costa et al.   LAB ON A CHIP

Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial

(2017) Nicola Logallo et al.   LANCET NEUROLOGY

Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase

(2017) Yanying Xu et al.   Microbial Cell Factories

Tenecteplase in ischemic stroke offers improved recanalization

(2017) Andrew Bivard et al.   NEUROLOGY

Engineering of Harobin for enhanced fibrinolytic activity obtained by random and site-directed mutagenesis

(2017) Zhuojian Li et al.   PROTEIN EXPRESSION AND PURIFICATION

Quantitative Imaging of Cerebral Thromboemboli In Vivo

(2017) Dong-Eog Kim et al.   STROKE

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

(2017) Shadi Yaghi et al.   STROKE

Development and validation of a high throughput whole blood thrombolysis plate assay

(2017) T. Bonnard et al.   Scientific Reports

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single‐Chain Antibody Specific for Activated GPIIb/IIIa

(2017) Thomas Bonnard et al.   Journal of the American Heart Association

Review of Protocols Used in Ultrasound Thrombolysis

(2017) Nicos Papadopoulos et al.   Journal of Stroke & Cerebrovascular Diseases

Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats

(2017) Mozhgan Raigani et al.   Scientific Reports

Nanoliposome containing cyclosporine A reduced neuroinflammation responses and improved neurological activities in cerebral ischemia/reperfusion in rat

(2016) Alireza Partoazar et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Tenecteplase versus alteplase in stroke thrombolysis: An individual patient data meta-analysis of randomized controlled trials

(2016) Xuya Huang et al.   International Journal of Stroke

Zebrafish model of photochemical thrombosis for translational research and thrombolytic screening in vivo

(2016) I-Ju Lee et al.   Journal of Biophotonics

Liposomal nanocarriers for plasminogen activators

(2016) Stepan Koudelka et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of Truncated Streptokinase Leads to Formulation of a Useful Drug with Ameliorated Attributes

(2016) Pooja Sawhney et al.   PLoS One

Engineering, expression and purification of a chimeric fibrin-specific streptokinase

(2016) Mohammad Naser Taheri et al.   PROTEIN EXPRESSION AND PURIFICATION

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke

(2016) Cyrille Orset et al.   STROKE

Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke

(2016) Rüdiger von Kummer et al.   STROKE

Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke

(2016) Grant Mair et al.   STROKE

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

(2016) Dong-Eog Kim et al.   Jove-Journal of Visualized Experiments

Amino-Terminal Fusion of Epidermal Growth Factor 4,5,6 Domains of Human Thrombomodulin on Streptokinase Confers Anti-Reocclusion Characteristics along with Plasmin-Mediated Clot Specificity

(2016) Neeraj Maheshwari et al.   PLoS One

Precise Characterization of the Penumbra Revealed by MRI: A Modified Photothrombotic Stroke Model Study

(2016) Cheng Qian et al.   PLoS One

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach

(2015) J. C. Ciciliano et al.   BLOOD

Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

(2015) Masato Kanazawa et al.   BRAIN

Simple quantitative measurement based on DWI to objectively judge DWI-FLAIR mismatch in a canine stroke model

(2015) Sheng Liu et al.   Diagnostic and Interventional Radiology

Opening the window: Ischemic postconditioning reduces the hyperemic response of delayed tissue plasminogen activator and extends its therapeutic time window in an embolic stroke model

(2015) Ali Esmaeeli-Nadimi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Temperature-sensitive liposome-mediated delivery of thrombolytic agents

(2015) Vishal Saxena et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Fibrinolytic enzyme production by newly isolated Bacillus cereus SRM-001 with enhanced in-vitro blood clot lysis potential

(2015) Manoj Kumar Narasimhan et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

A novel mouse model of thromboembolic stroke

(2015) Yingxin Chen et al.   JOURNAL OF NEUROSCIENCE METHODS

Penta-l-lysine Potentiates Fibrin-Independent Activity of Human Tissue Plasminogen Activator

(2015) Mohammad Rehan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Engineering of plasminogen activators for targeting to thrombus and heightening thrombolytic efficacy

(2015) S. Absar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Safety and efficacy of desmoteplase given 3–9 h after ischaemic stroke in patients with occlusion or high-grade stenosis in major cerebral arteries (DIAS-3): a double-blind, randomised, placebo-controlled phase 3 trial

(2015) Gregory W Albers et al.   LANCET NEUROLOGY

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons

(2015) Morgane Louessard et al.   MOLECULAR NEUROBIOLOGY

Focal embolic cerebral ischemia in the rat

(2015) Li Zhang et al.   Nature Protocols

Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke

(2015) Tudor G. Jovin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles

(2015) Jeong-Yeon Kim et al.   Theranostics

Targeted Drug Delivery to Flow-Obstructed Blood Vessels Using Mechanically Activated Nanotherapeutics

(2015) Netanel Korin et al.   JAMA Neurology

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

(2015) Natalie K. Fan et al.   Jove-Journal of Visualized Experiments

Simple quantitative measurement based on DWI to objectively judge DWI-FLAIR mismatch in a canine stroke model

(2015) Sheng Liu et al.   Diagnostic and Interventional Radiology

Neuroprotective Effect of Asiatic Acid in Rat Model of Focal Embolic Stroke

(2014) Ki Yong Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Design of a novel chimeric tissue plasminogen activator with favorable Vampire bat plasminogen activator properties

(2014) MohammadReza Kazemali et al.   ENZYME AND MICROBIAL TECHNOLOGY

Induction and imaging of photothrombotic stroke in conscious and freely moving rats

(2014) Hongyang Lu et al.   JOURNAL OF BIOMEDICAL OPTICS

A Rat Model of Photothrombotic Capsular Infarct with a Marked Motor Deficit: A Behavioral, Histologic, and microPET Study

(2014) Hyung-Sun Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

(2014) Jonathan Emberson et al.   LANCET

Expression of a Novel Chimeric-Truncated tPA in Pichia pastoris with Improved Biochemical Properties

(2014) Amirhossein Saadatirad et al.   MOLECULAR BIOTECHNOLOGY

Comparative study of the relative signal intensity on DWI, FLAIR, and T2 images in identifying the onset time of stroke in an embolic canine model

(2014) Xiao-quan Xu et al.   NEUROLOGICAL SCIENCES

Inflammatory cell recruitment after experimental thromboembolic stroke in rats

(2014) J. Lehmann et al.   NEUROSCIENCE

Embolic Middle Cerebral Artery Occlusion (MCAO) for Ischemic Stroke with Homologous Blood Clots in Rats

(2014) Rong Jin et al.   Jove-Journal of Visualized Experiments

Hyperacute direct thrombus imaging using computed tomography and gold nanoparticles

(2013) Dong-Eog Kim et al.   ANNALS OF NEUROLOGY

Activity assessment of microbial fibrinolytic enzymes

(2013) Essam Kotb   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Quantitative Dissection of the Binding Contributions of Ligand Lysines of the Receptor-associated Protein (RAP) to the Low Density Lipoprotein Receptor-related Protein (LRP1)

(2013) Klavs Dolmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates

(2013) M. Gauberti et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

tPA Regulates Neurite Outgrowth by Phosphorylation of LRP5/6 in Neural Progenitor Cells

(2013) Sung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Sonic Hedgehog Signaling Pathway Mediates Cerebrolysin-Improved Neurological Function After Stroke

(2013) Li Zhang et al.   STROKE

Displacement of Sensory Maps and Disorganization of Motor Cortex After Targeted Stroke in Mice

(2013) T. C. Harrison et al.   STROKE

A Model of Rat Embolic Cerebral Infarction with a Quantifiable, Autologous Arterial Blood Clot

(2013) Norihito Shimamura et al.   Translational Stroke Research

Characterization of a New Model of Thromboembolic Stroke in C57 black/6J mice

(2013) Saema Ansar et al.   Translational Stroke Research

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

(2012) B. Niego et al.   BLOOD

Streptococcus uberisPlasminogen Activator (SUPA) Activates Human Plasminogen through Novel Species-specific and Fibrin-targeted Mechanisms

(2012) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined treatment with recombinant tissue plasminogen activator and dexamethasone phosphate-containing liposomes improves neurological outcome and restricts lesion progression after embolic stroke in rats

(2012) Ivo A. C. W. Tiebosch et al.   JOURNAL OF NEUROCHEMISTRY

Embolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in rat

(2012) Ming Ren et al.   JOURNAL OF NEUROSCIENCE METHODS

tPA-S481A Prevents Neurotoxicity of Endogenous tPA in Traumatic Brain Injury

(2012) William M. Armstead et al.   JOURNAL OF NEUROTRAUMA

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

(2012)   LANCET

The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

(2012) Andy Y Shih et al.   NATURE NEUROSCIENCE

Should clot composition affect choice of endovascular therapy?

(2012) B. P. Mehta et al.   NEUROLOGY

A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke

(2012) Mark Parsons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrasound-Enhanced Thrombolytic Effect of Tissue Plasminogen Activator–Loaded Echogenic Liposomes in an In Vivo Rabbit Aorta Thrombus Model—Brief Report

(2011) Susan T. Laing et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel variant of t-PA resistant to plasminogen activator inhibitor-1; expression in CHO cells based on In Silico experiments

(2011) Fatemeh Davami et al.   BMB Reports

A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator

(2011) Paul Y. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laser speckle contrast imaging of cerebral blood flow in freely moving animals

(2011) Peng Miao et al.   JOURNAL OF BIOMEDICAL OPTICS

Thrombotic distal middle cerebral artery occlusion produced by topical FeCl3 application: A novel model suitable for intravital microscopy and thrombolysis studies

(2011) Hulya Karatas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

First Structural Model of Full-Length Human Tissue-Plasminogen Activator: A SAXS Data-Based Modeling Study

(2011) Yogendra S. Rathore et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Dodecafluoropentane Emulsion Decreases Infarct Volume in a Rabbit Ischemic Stroke Model

(2011) William C. Culp et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

A low molecular weight chymotrypsin-like novel fibrinolytic enzyme from Streptomyces sp. CS624

(2011) Poonam Mander et al.   PROCESS BIOCHEMISTRY

Direct Thrombus Imaging as a Means to Control the Variability of Mouse Embolic Infarct Models

(2011) Dong-Eog Kim et al.   STROKE

Principles and Practice of Thromboelastography in Clinical Coagulation Management and Transfusion Practice

(2011) Daniel Bolliger et al.   TRANSFUSION MEDICINE REVIEWS

The Effectiveness of Activators in Clot Lysis, with Special Reference to Fibrinolytic Therapy: A New Method for Determination of Preformed Clot Lysis

(2010) Sverre Blix   ACTA MEDICA SCANDINAVICA

Expression of a Novel Chimeric Truncated t-PA in CHO Cells Based on in Silico Experiments

(2010) Fatemeh Davami et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke

(2010) Rohit Bhatia et al.   STROKE

The Tissue-Type Plasminogen Activator Story

(2009) D. Collen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP

(2009) Jan K. Jensen et al.   BIOCHEMICAL JOURNAL

The use of PEGylated liposomes to prolong circulation lifetimes of tissue plasminogen activator

(2009) Ji-Young Kim et al.   BIOMATERIALS

Both compensation and recovery of skilled reaching following small photothrombotic stroke to motor cortex in the rat

(2009) Seong-Keun Moon et al.   EXPERIMENTAL NEUROLOGY

Atorvastatin Extends the Therapeutic Window for tPA to 6 h after the Onset of Embolic Stroke in Rats

(2009) Li Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke

(2009) E. J. SU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel recombinant thrombolytic and antithrombotic staphylokinase variants with an RGD motif at their N-termini

(2008) Jintian He et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study

(2008) Werner Hacke et al.   LANCET NEUROLOGY

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blocking of Platelets or Intrinsic Coagulation Pathway–Driven Thrombosis Does Not Prevent Cerebral Infarctions Induced by Photothrombosis

(2008) Christoph Kleinschnitz et al.   STROKE

Development of a Rat Model of Photothrombotic Ischemia and Infarction Within the Caudoputamen

(2008) Toshihiko Kuroiwa et al.   STROKE