The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

(2018) Yan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex

(2018) Wei-wei Gao et al.   MOLECULAR CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability

(2018) Christina N. Vallianatos et al.   Frontiers in Molecular Neuroscience

Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex

(2018) Koushik Ghosh et al.   Cell Reports

KDM5 histone demethylases repress immune response via suppression of STING

(2018) Lizhen Wu et al.   PLOS BIOLOGY

Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance

(2018) Megha Budhwani et al.   Frontiers in Oncology

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

(2016) Jun Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

(2016) Hongjie Shen et al.   CELL

ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes

(2016) Na Li et al.   MOLECULAR CELL

Structural analysis of human KDM5B guides histone demethylase inhibitor development

(2016) Catrine Johansson et al.   Nature Chemical Biology

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

(2016) Ann-Sofie B. Brier et al.   NUCLEIC ACIDS RESEARCH

Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression

(2016) Liming Xu et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer

(2016) Huimei Yu et al.   Oncotarget

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

(2016) Pavel Savitsky et al.   Cell Reports

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

(2016) Shigeki Iwase et al.   Cell Reports

Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression

(2015) Qin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

(2015) Xuening Ji et al.   BMC CANCER

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity

(2015) Emily Brookes et al.   HUMAN MOLECULAR GENETICS

Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8

(2015) Santanu Adhikary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

(2015) Beatrice Rondinelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif

(2015) Xingyin Liu et al.   Cell Reports

KDM5C Is Overexpressed in Prostate Cancer and Is a Prognostic Marker for Prostate-Specific Antigen-Relapse Following Radical Prostatectomy

(2014) Johannes Stein et al.   AMERICAN JOURNAL OF PATHOLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer

(2014) Shoji Yamamoto et al.   CANCER CELL

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

(2014) Qin Feng et al.   CELL RESEARCH

Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression

(2014) Junya Kuroyanagi et al.   FEBS LETTERS

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer

(2014) Mark A. Wade et al.   NUCLEIC ACIDS RESEARCH

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

(2013) Wen Liu et al.   CELL

Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines

(2013) Hiroyuki Yamazaki et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

(2013) Charles E. Foulds et al.   MOLECULAR CELL

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

(2013) Wenbo Li et al.   NATURE

A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability

(2012) Katrin Õunap et al.   European Journal of Medical Genetics

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

(2011) L. DiTacchio et al.   SCIENCE

Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation

(2010) Wanli Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Essential Functions of the Histone Demethylase Lid

(2010) Ling Li et al.   PLoS Genetics

Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype–phenotype correlation

(2009) Sinitdhorn Rujirabanjerd et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A novel mutation inJARID1C/SMCX in a patient with autism spectrum disorder (ASD)

(2008) Abidemi Adegbola et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A