Circular RNA: an important player with multiple facets to regulate its parental gene expression

Circular RNA hsa_circ_0061825 (circ‐TFF1) contributes to breast cancer progression through targeting miR‐326/TFF1 signalling

(2020) Gaofeng Pan et al.   CELL PROLIFERATION

CircRNA-AKT1 sequesters miR-942-5p to upregulate AKT1 and promote cervical cancer progression

(2020) Rongying Ou et al.   Molecular Therapy-Nucleic Acids

A circular RNA derived from DAB1 promotes cell proliferation and osteogenic differentiation of BMSCs via RBPJ/DAB1 axis

(2020) Weekai Chia et al.   Cell Death & Disease

circNFATC3 sponges miR‐548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression

(2020) Changchang Jia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction

(2020) Qin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2

(2020) Yanfeng Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61

(2020) Jun Chen et al.   Cell Death & Disease

circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells

(2019) Peng Kong et al.   NUCLEIC ACIDS RESEARCH

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression

(2019) Hongwei Su et al.   Molecular Cancer

Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery

(2019) Nan Wu et al.   CELL DEATH AND DIFFERENTIATION

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

(2019) Zhuoan Cheng et al.   Nature Communications

A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability

(2019) Bing Xia et al.   CELL TRANSPLANTATION

A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1

(2019) Xin Xia et al.   Molecular Cancer

CircAmotl1 motivates Amotl1 expression to facilitate cervical cancer growth

(2019) Rongying Ou et al.   Molecular Therapy-Nucleic Acids

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation

(2019) Feng Yang et al.   Molecular Cancer

CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1

(2019) Jiayu Zhou et al.   Cell Death & Disease

Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO

(2019) Zhiyong Xiong et al.   Aging-US

circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer

(2019) Feng Ye et al.   Molecular Therapy-Nucleic Acids

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

(2018) Bing Han et al.   Autophagy

Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7

(2018) Xiaomin Li et al.   JOURNAL OF PATHOLOGY

A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy

(2018) William W. Du et al.   ONCOGENE

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

(2018) Maolei Zhang et al.   ONCOGENE

Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons

(2018) Simona Aufiero et al.   RNA

Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway

(2018) Zhihua Zeng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346

(2018) Ning Bai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells

(2018) Dengliang Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

(2017) Rongfang He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

(2017) Lorenzo Errichelli et al.   Nature Communications

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression

(2017) Shashi Kumar Gupta et al.   CIRCULATION RESEARCH

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Metazoan tRNA introns generate stable circular RNAs in vivo

(2015) Zhipeng Lu et al.   RNA

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rolling Circle Translation of Circular RNA in Living Human Cells

(2015) Naoko Abe et al.   Scientific Reports

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway

(2015) Guanli Huang et al.   PLoS One

Biogenesis of Circular RNAs

(2014) Quentin Vicens et al.   CELL

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Efficient backsplicing produces translatable circular mRNAs

(2014) Yang Wang et al.   RNA

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Regulation of gene expression via the core promoter and the basal transcriptional machinery

(2009) Tamar Juven-Gershon et al.   DEVELOPMENTAL BIOLOGY