A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

(2019) Jianping Guo et al.   NATURE CELL BIOLOGY

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

(2019) Guihua Wang et al.   NATURE CELL BIOLOGY

The Landscape of Circular RNA in Cancer

(2019) Josh N. Vo et al.   CELL

Widespread and Functional RNA Circularization in Localized Prostate Cancer

(2019) Sujun Chen et al.   CELL

Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression

(2019) Xiaoxu Huang et al.   Molecular Cancer

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

(2018) Maolei Zhang et al.   ONCOGENE

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

(2018) Maolei Zhang et al.   Nature Communications

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

(2017) Hua-fu Zhao et al.   Molecular Cancer

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression

(2016) Anna Joy et al.   JOURNAL OF NEURO-ONCOLOGY

Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression

(2015) Kristen M. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

(2014) Emmanuel Chautard et al.   JOURNAL OF NEURO-ONCOLOGY

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

PTEN-Deficient Tumors Depend on AKT2 for Maintenance and Survival

(2014) Y. R. Chin et al.   Cancer Discovery

Targeting Akt3 Signaling in Triple-Negative Breast Cancer

(2013) Y. R. Chin et al.   CANCER RESEARCH

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Nonredundant Functions for Akt Isoforms in Astrocyte Growth and Gliomagenesis in an Orthotopic Transplantation Model

(2011) R. Endersby et al.   CANCER RESEARCH

Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells

(2011) Tiera A. Liby et al.   INTERNATIONAL JOURNAL OF CANCER

Akt2 and Akt3 play a pivotal role in malignant gliomas

(2011) H. Mure et al.   NEURO-ONCOLOGY

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

(2011) J R Molina et al.   ONCOGENE

Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells

(2010) Y. Shao et al.   CANCER RESEARCH

A silver lining on the horizon for glioblastoma

(2009) Jonathan P Knisely et al.   LANCET ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE