SIRT1 Inhibits Apoptosis by Promoting Autophagic Flux in Human Nucleus Pulposus Cells in the Key Stage of Degeneration via ERK Signal Pathway

Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy

(2019) Jiang Fang et al.   Frontiers in Neuroscience

Assessment of changes in the micro-nano environment of intervertebral disc degeneration based on Pfirrmann grade

(2019) Yan-Jun Che et al.   Spine Journal

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

(2019) Y. Kakiuchi et al.   OSTEOARTHRITIS AND CARTILAGE

Primary cilia and autophagy interaction is involved in mechanical stress mediated cartilage development via ERK/mTOR axis

(2019) Wei Xiang et al.   LIFE SCIENCES

Role of sirtuin-1 in diabetic nephropathy

(2019) Wanning Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR

(2019) Boya Zhang et al.   JOURNAL OF VIROLOGY

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review

(2018) Prasanthi Sampara et al.   GENE THERAPY

LncRNA MALAT1 protects cardiomyocytes from isoproterenol‐induced apoptosis through sponging miR‐558 to enhance ULK1‐mediated protective autophagy

(2018) Xiaoyan Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

(2018) Shanshan Wang et al.   Cell Death & Disease

Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells

(2018) Pengfei Liang et al.   Cell Death & Disease

Intervertebral Disk Degeneration and Repair

(2017) James Dowdell et al.   NEUROSURGERY

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

(2017) M. Ito et al.   OSTEOARTHRITIS AND CARTILAGE

The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

(2017) Zhi-Hua Ouyang et al.   Oncotarget

Autophagy: A double-edged sword in intervertebral disk degeneration

(2016) Shu-Jun Zhang et al.   CLINICA CHIMICA ACTA

In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model

(2016) John T. Martin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Astrocytes Grown in Alvetex® Three Dimensional Scaffolds Retain a Non-reactive Phenotype

(2016) Christopher I. Ugbode et al.   NEUROCHEMICAL RESEARCH

Genome-Wide Identification of Long Noncoding RNAs in Human Intervertebral Disc Degeneration by RNA Sequencing

(2016) Bo Zhao et al.   Biomed Research International

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs

(2014) Louise E Clarke et al.   ARTHRITIS RESEARCH & THERAPY

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

(2014) Wei Jiang et al.   Scientific Reports

SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway

(2012) DaWu Wang et al.   AGE

Autophagic cell death exists

(2012) Peter G.H. Clarke et al.   Autophagy

Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats

(2012) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats

(2011) Yue-Hui Zhang et al.   APOPTOSIS

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes

(2010) Peng Cao et al.   Spine Journal

Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells

(2010) H L Bennett et al.   Cell Death & Disease

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design