Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review

Intervertebral Disk Degeneration and Repair

(2017) James Dowdell et al.   NEUROSURGERY

Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells

(2017) Kang Lu et al.   Stem Cell Research & Therapy

MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1

(2017) Weiming Li et al.   World Neurosurgery

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update

(2016) Michael Monfett et al.   INTERNATIONAL ORTHOPAEDICS

Recent Advances in Nucleic Acid-Based Delivery: From Bench to Clinical Trials in Genetic Diseases

(2016) Cláudia Oliveira et al.   Journal of Biomedical Nanotechnology

PDGF-BB Delays Degeneration of the Intervertebral Discs in a Rabbit Preclinical Model

(2016) David N. Paglia et al.   SPINE

Lentivirus-mediated TGF-β3, CTGF and TIMP1 gene transduction as a gene therapy for intervertebral disc degeneration in an in vivo rabbit model

(2016) YONG LIU et al.   Experimental and Therapeutic Medicine

Stem cells sources for intervertebral disc regeneration

(2016) Gianluca Vadalà et al.   World Journal of Stem Cells

Delivery systems for the treatment of degenerated intervertebral discs

(2015) S.B.G. Blanquer et al.   ADVANCED DRUG DELIVERY REVIEWS

The Effects of Platelet-Rich Plasma on Halting the Progression in Porcine Intervertebral Disc Degeneration

(2015) Hongsik Cho et al.   ARTIFICIAL ORGANS

MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-α-induced apoptosis by targeting JunD

(2015) Tao Wang et al.   BIOCHIMIE

MicroRNA-93 regulates collagen loss by targeting MMP3 in human nucleus pulposus cells

(2015) Wanli Jing et al.   CELL PROLIFERATION

Lumbar Disc Degeneration is Facilitated by MiR-100-Mediated FGFR3 Suppression

(2015) Ning Yan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNAs: New players in intervertebral disc degeneration

(2015) Cheng Wang et al.   CLINICA CHIMICA ACTA

MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc

(2015) Su-Xi Gu et al.   GENE

Adeno-associated virus-mediated BMP-7 and SOX9 in vitro co-transfection of human degenerative intervertebral disc cells

(2015) X.F. Ren et al.   GENETICS AND MOLECULAR RESEARCH

Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up

(2015) Kenneth Pettine et al.   INTERNATIONAL ORTHOPAEDICS

Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14

(2015) Ming-liang Ji et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

Microarray based analysis of gene regulation by microRNA in intervertebral disc degeneration

(2015) PENG HU et al.   Molecular Medicine Reports

Caspase 3 Silencing Inhibits Biomechanical Overload–Induced Intervertebral Disk Degeneration

(2014) Katsuhisa Yamada et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

(2014) Tiffany Kadow et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases

(2014) Jagat R. Kanwar et al.   DRUG DISCOVERY TODAY

Platelet-rich plasma induces annulus fibrosus cell proliferation and matrix production

(2014) T. N. Pirvu et al.   EUROPEAN SPINE JOURNAL

miR-21 Promotes Human Nucleus Pulposus Cell Proliferation through PTEN/AKT Signaling

(2014) Hongzhe Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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(2014) Elias Vasiliadis et al.   MOLECULAR MEDICINE

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Effects of Transplantation of hTIMP-1–Expressing Bone Marrow Mesenchymal Stem Cells on the Extracellular Matrix of Degenerative Intervertebral Discs in an In Vivo Rabbit Model

(2014) Zhou Yi et al.   SPINE

A Systematic Review of the Safety and Efficacy of Mesenchymal Stem Cells for Disc Degeneration: Insights and Future Directions for Regenerative Therapeutics

(2014) Rita Lok-Hay Yim et al.   STEM CELLS AND DEVELOPMENT

Link N and Mesenchymal Stem Cells Can Induce Regeneration of the Early Degenerate Intervertebral Disc

(2014) Fackson Mwale et al.   TISSUE ENGINEERING PART A

Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study

(2014) Zhong-Yuan Wan et al.   ARTHRITIS RESEARCH & THERAPY

Cell death in intervertebral disc degeneration

(2013) Fan Ding et al.   APOPTOSIS

Characterization of miRNA Expression in Human Degenerative Lumbar Disks

(2013) Søren Ohrt-Nissen et al.   CONNECTIVE TISSUE RESEARCH

Characterization of microRNA expression profiles in patients with intervertebral disc degeneration

(2013) BO ZHAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Treatment of rabbit intervertebral disc degeneration with co-transfection by adeno-associated virus-mediated SOX9 and osteogenic protein-1 double genes in vivo

(2013) SHAN REN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of adenoviral vector expressing hIGF-1 on apoptosis in nucleus pulposus cells in vitro

(2013) CHANG-CHUN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Intervertebral disc regeneration: from the degenerative cascade to molecular therapy and tissue engineering

(2013) Gianluca Vadalà et al.   Journal of Tissue Engineering and Regenerative Medicine

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

MiR-27a Regulates Apoptosis in Nucleus Pulposus Cells by Targeting PI3K

(2013) Gang Liu et al.   PLoS One

MicroRNA-10b Promotes Nucleus Pulposus Cell Proliferation through RhoC-Akt Pathway by Targeting HOXD10 in Intervetebral Disc Degeneration

(2013) Xin Yu et al.   PLoS One

PKCε Signalling Activates ERK1/2, and Regulates Aggrecan, ADAMTS5, and miR377 Gene Expression in Human Nucleus Pulposus Cells

(2013) Emmanouella Tsirimonaki et al.   PLoS One

Adjacent segment disease in the lumbar spine following different treatment interventions

(2013) Kristen E. Radcliff et al.   Spine Journal

Genetic polymorphisms associated with intervertebral disc degeneration

(2013) Jillian E. Mayer et al.   Spine Journal

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Tissue-Engineered Allograft Intervertebral Disc Transplantation for the Treatment of Degenerative Disc Disease: Experimental Study in a Beagle Model

(2012) Hongkui Xin et al.   TISSUE ENGINEERING PART A

Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study

(2012) Shuji Obata et al.   ARTHRITIS RESEARCH & THERAPY

Strategies to identify long noncoding RNAs involved in gene regulation

(2012) Catherine Lee et al.   Cell and Bioscience

Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats

(2011) Yue-Hui Zhang et al.   APOPTOSIS

Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits

(2011) Hideki Sudo et al.   ARTHRITIS AND RHEUMATISM

The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1

(2011) Anthony J. Hayes et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Adequacy of herniated disc tissue as a cell source for nucleus pulposus regeneration

(2011) Aldemar A. Hegewald et al.   JOURNAL OF NEUROSURGERY-SPINE

Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration

(2011) Ganjun Feng et al.   JOURNAL OF NEUROSURGERY-SPINE

Effects of adeno-associated virus-2-mediated human BMP-7 gene transfection on the phenotype of nucleus pulposus cells

(2011) Chaofeng Wang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3

(2011) Hai-Qiang Wang et al.   JOURNAL OF PATHOLOGY

Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation

(2011) Gianluca Vadalà et al.   Journal of Tissue Engineering and Regenerative Medicine

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

In Vitro and in Vivo Testing of a Novel Regulatory System for Gene Therapy for Intervertebral Disc Degeneration

(2011) Gwendolyn Sowa et al.   SPINE

Tissue Engineering of the Intervertebral Disc With Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Growth Factors

(2011) Kwang-Il Lee et al.   SPINE

Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model

(2011) Steven K. Leckie et al.   Spine Journal

Porcine Intervertebral Disc Repair Using Allogeneic Juvenile Articular Chondrocytes or Mesenchymal Stem Cells

(2011) Frank L. Acosta et al.   TISSUE ENGINEERING PART A

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing

(2009) Tapio Videman et al.   ARTHRITIS AND RHEUMATISM

Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma

(2009) Wei-Hong Chen et al.   BIOMATERIALS

Sustained long-term RNA interference in nucleus pulposus cells in vivo mediated by unmodified small interfering RNA

(2009) Teppei Suzuki et al.   EUROPEAN SPINE JOURNAL

Biologic Response of Human Intervertebral Disc Cells to Gene Therapy Cocktail

(2009) Seong-Hwan Moon et al.   SPINE

Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals

(2009) Kenneth M. C. Cheung et al.   SPINE

Characterization of In Vivo Effects of Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel Microspheres on Degenerated Intervertebral Discs

(2009) Kazuhide Sawamura et al.   TISSUE ENGINEERING PART A

Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model

(2009) Shoji Seki et al.   ARTHRITIS RESEARCH & THERAPY

Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc

(2008) Nobuyuki Fujita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stem cell regeneration of degenerated intervertebral discs: Current status

(2008) Stephen M. Richardson et al.   Current Pain and Headache Reports

The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells

(2007) Lars Gilbertson et al.   Spine Journal

Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression

(2007) Min Cui et al.   Spine Journal