Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration

Hyperoxia Injury in the Developing Lung is Mediated by Mesenchymal Expression of Wnt5A

(2020) Jennifer M.S. Sucre et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Glucocorticoid Regulates Mesenchymal Cell Differentiation Required for Perinatal Lung Morphogenesis and Function

(2020) James P Bridges et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

(2020) Maria C. Basil et al.   Cell Stem Cell

Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface

(2020) Rongbo Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The Elephant in the Lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration

(2020) Matt Riccetti et al.   MATRIX BIOLOGY

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

The Idiopathic Pulmonary Fibrosis Cell Atlas

(2020) Nir Neumark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice

(2020) Min Yee et al.   Scientific Reports

Mesenchymal Cells and Bronchopulmonary Dysplasia: New Insights about the Dark Side of Oxygen

(2019) Antonia P. Popova   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Tcf21 lineage constitutes the lung lipofibroblast population

(2019) Juwon Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The secondary crest myofibroblast PDGFRα controls elastogenesis pathway via a secondary tier of signaling networks during alveologenesis

(2019) C. Li et al.   DEVELOPMENT

Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 ( Fgf18 )

(2019) Andrew S. Hagan et al.   DEVELOPMENTAL DYNAMICS

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

(2019) Vahid Kheirollahi et al.   Nature Communications

Editorial Focus on: "Mechanisms of Moderate Hypoxia Effects on Developing Human Lung Fibroblasts".

(2019) Jennifer M.S. Sucre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

(2019) Eleanor Valenzi et al.   ANNALS OF THE RHEUMATIC DISEASES

Bronchopulmonary dysplasia

(2019) Bernard Thébaud et al.   Nature Reviews Disease Primers

Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis

(2019) Andrew S. Hagan et al.   DEVELOPMENT

PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung

(2018) Leonor Gouveia et al.   DEVELOPMENT

Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation

(2018) Mei-I Chung et al.   DEVELOPMENT

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

(2018) Paul J Wolters et al.   Lancet Respiratory Medicine

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis

(2018) Shin-Ichi Nureki et al.   JOURNAL OF CLINICAL INVESTIGATION

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

(2018) Rongbo Li et al.   eLife

Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury

(2018) Tingting Yuan et al.   Frontiers in Genetics

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth

(2018) Minzhe Guo et al.   Nature Communications

Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development

(2017) Alena Moiseenko et al.   STEM CELLS

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development

(2017) Yina Du et al.   THORAX

Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity

(2016) Jenna Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Looking ahead: where to next for animal models of bronchopulmonary dysplasia?

(2016) Claudio Nardiello et al.   CELL AND TISSUE RESEARCH

A three-dimensional study of alveologenesis in mouse lung

(2016) Kelsey Branchfield et al.   DEVELOPMENTAL BIOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Successful Concomitant Therapy with Pirfenidone and Nintedanib in Idiopathic Pulmonary Fibrosis: A Case Report

(2016) Lars Hagmeyer et al.   RESPIRATION

Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation

(2016) David B. Frank et al.   Cell Reports

Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development

(2015) Aglaia Ntokou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice

(2015) Stephen E. McGowan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The pulmonary mesenchyme directs lung development

(2015) David McCulley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development

(2015) D. Al Alam et al.   DEVELOPMENT

Risk factors and early origins of chronic obstructive pulmonary disease

(2015) Dirkje S Postma et al.   LANCET

Sex steroid signaling: Implications for lung diseases

(2015) Venkatachalem Sathish et al.   PHARMACOLOGY & THERAPEUTICS

Progenitors of Secondary Crest Myofibroblasts Are Developmentally Committed in Early Lung Mesoderm

(2015) Changgong Li et al.   STEM CELLS

Bleomycin induced epithelial–mesenchymal transition (EMT) in pleural mesothelial cells

(2015) Li-Jun Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

How common is the lipid body-containing interstitial cell in the mammalian lung?

(2014) Daniel Tahedl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

In search of the elusive lipofibroblast in human lungs

(2014) Katrin Ahlbrecht et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of bronchopulmonary dysplasia. The term mouse models

(2014) Jessica Berger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in mice

(2014) Stephen E. McGowan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models

(2014) Carl T. D'Angio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Lung Alveolar Lipofibroblast: An Evolutionary Strategy Against Neonatal Hyperoxic Lung Injury

(2014) Virender K. Rehan et al.   ANTIOXIDANTS & REDOX SIGNALING

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Hyperoxic Lung Injury Model in Premature Rabbits: The Influence of Different Gestational Ages and Oxygen Concentrations

(2014) Roberta Munhoz Manzano et al.   PLoS One

Hedgehog Signaling in Neonatal and Adult Lung

(2013) Li Liu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally

(2013) E. El Agha et al.   DEVELOPMENT

Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor

(2013) Tien Peng et al.   NATURE

Platelet-derived growth factor-A regulates lung fibroblast S-phase entry through p27kip1 and FoxO3a

(2013) Stephen E McGowan et al.   RESPIRATORY RESEARCH

Progress in understanding the pathogenesis of BPD using the baboon and sheep models

(2013) Kurt H. Albertine   SEMINARS IN PERINATOLOGY

Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy

(2013) Julia A. Paxson et al.   STEM CELLS AND DEVELOPMENT

Dynamic Regulation of Platelet-Derived Growth Factor Receptor α Expression in Alveolar Fibroblasts during Realveolarization

(2012) Leiling Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evidence for Adult Lung Growth in Humans

(2012) James P. Butler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Development

(2012) Elie El Agha et al.   PLoS One

Spatial and Temporal Analysis of Extracellular Matrix Proteins in the Developing Murine Heart: A Blueprint for Regeneration

(2012) Kevin P. Hanson et al.   TISSUE ENGINEERING PART A

Long-term failure of alveologenesis after an early short-term exposure to a PDGF-receptor antagonist

(2011) Mandy Lau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The a“MAZE”ing World of Lung-Specific Transgenic Mice

(2011) Emma L. Rawlins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways

(2011) A. Lazarus et al.   DEVELOPMENT

Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung

(2011) Jing Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fibroblasts Expressing PDGF-Receptor-Alpha Diminish During Alveolar Septal Thinning in Mice

(2011) Stephen E McGowan et al.   PEDIATRIC RESEARCH

Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development

(2011) Marie-Laure Franco-Montoya et al.   PHYSIOLOGICAL GENOMICS

Age-Dependent Decline in Mouse Lung Regeneration with Loss of Lung Fibroblast Clonogenicity and Increased Myofibroblastic Differentiation

(2011) Julia A. Paxson et al.   PLoS One

Pulmonary fibroblasts from COPD patients show an impaired response of elastin synthesis to TGF-β1

(2011) Jing Zhang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

(2011) L. Plantier et al.   THORAX

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

(2010) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fibroblast Growth Factor Receptors Control Epithelial–Mesenchymal Interactions Necessary for Alveolar Elastogenesis

(2010) Sorachai Srisuma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The new bronchopulmonary dysplasia

(2010) Alan H Jobe   CURRENT OPINION IN PEDIATRICS

FGF signaling is required for myofibroblast differentiation during alveolar regeneration

(2009) Anne-Karina T. Perl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis

(2009) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

(2009) Thomas H. Sisson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fibrillar Collagen Clamps Lung Mesenchymal Cells in a Nonproliferative and Noncontractile Phenotype

(2009) Michael J. Schuliga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neuraminidase-1 is required for the normal assembly of elastic fibers

(2008) Barry Starcher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung Fibroblast Repair Functions in Patients with Chronic Obstructive Pulmonary Disease Are Altered by Multiple Mechanisms

(2008) Shinsaku Togo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database

(2008) P. M. McGowan et al.   ANNALS OF ONCOLOGY

The Pathology of Chronic Obstructive Pulmonary Disease

(2008) James C. Hogg et al.   Annual Review of Pathology-Mechanisms of Disease

Developmental alveolarization of the mouse lung

(2008) Sonja I. Mund et al.   DEVELOPMENTAL DYNAMICS

Changes in elastic fibres in the small airways and alveoli in COPD

(2008) P. N. Black et al.   EUROPEAN RESPIRATORY JOURNAL

Idiopathic pulmonary fibrosis

(2008) Eric B Meltzer et al.   Orphanet Journal of Rare Diseases