MARK2 phosphorylates eIF2α in response to proteotoxic stress

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

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One step generation of customizable gRNA vectors for multiplex CRISPR approaches through string assembly gRNA cloning (STAgR)

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Homing in: Mechanisms of Substrate Targeting by Protein Kinases

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Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

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Integrated stress response of vertebrates is regulated by four eIF2α kinases

(2016) Shusuke Taniuchi et al.   Scientific Reports

Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription

(2015) Goran Periz et al.   PLOS BIOLOGY

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

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STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus inDrosophila

(2014) Kai Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An enhanced integrated stress response ameliorates mutant SOD1-induced ALS

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Construction of human activity-based phosphorylation networks

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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

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State of play in amyotrophic lateral sclerosis genetics

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

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A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death

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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

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Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling

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Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

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Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

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Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

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ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

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Adapting Proteostasis for Disease Intervention

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TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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