Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription

Quantitation of autophagy by luciferase release assay

(2014) Robin Ketteler et al.   Autophagy

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

(2014) Meredith E. Jackrel et al.   CELL

Regulation of p53 Level by UBE4B in Breast Cancer

(2014) Ying Zhang et al.   PLoS One

Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis

(2012) Claudia Fiorini et al.   APOPTOSIS

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

(2012) David Vilchez et al.   NATURE

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

A neuroprotective role for the DNA damage checkpoint in tauopathy

(2011) Vikram Khurana et al.   AGING CELL

UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation

(2011) Hong Wu et al.   CELL CYCLE

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

(2011) Tao Zhang et al.   HUMAN MOLECULAR GENETICS

A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43

(2011) N. A. Lanson et al.   HUMAN MOLECULAR GENETICS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

(2011) V M Renault et al.   ONCOGENE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

(2010) Tjakko J. van Ham et al.   CELL

Increased E4 Activity in Mice Leads to Ubiquitin-containing Aggregates and Degeneration of Hypothalamic Neurons Resulting in Obesity

(2010) Etsuo Susaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

(2010) G. P. Ritson et al.   JOURNAL OF NEUROSCIENCE

Alternative Splicing of the Histone Demethylase LSD1/KDM1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System

(2010) C. Zibetti et al.   JOURNAL OF NEUROSCIENCE

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins

(2009) Giacomo Morreale et al.   FEBS Journal

FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases

(2009) J. Mojsilovic-Petrovic et al.   JOURNAL OF NEUROSCIENCE

PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification

(2009) Athanasia Spandidos et al.   NUCLEIC ACIDS RESEARCH

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

(2009) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

p53: The Janus of autophagy?

(2008) Beth Levine et al.   NATURE CELL BIOLOGY

Caenorhabditis elegans mutant allele identification by whole-genome sequencing

(2008) Sumeet Sarin et al.   NATURE METHODS

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

(2008) Robin Ketteler et al.   GENOME BIOLOGY