Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Current and future treatments of pulmonary arterial hypertension

(2020) Natascha Sommer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria

(2020) Silverio Perrotta et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Genomics and Genetics of Oxygen Homeostasis

(2020) Gregg L. Semenza   Annual Review of Genomics and Human Genetics

Hypoxia‐induced pulmonary hypertension – utilising experiments of nature

(2020) Max Gassmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Iron bioavailability and cardiopulmonary function during ascent to very high altitude

(2020) David A. Holdsworth et al.   EUROPEAN RESPIRATORY JOURNAL

Prevalence of chronic obstructive pulmonary disease at high altitude: a systematic review and meta-analysis

(2020) Huaiyu Xiong et al.   PeerJ

Pulmonary hypertension in low- and middle-income countries with focus on sub-Saharan Africa

(2020) Anastase Dzudie et al.   Cardiovascular Diagnosis and Therapy

Iron deficiency is a possible risk factor causing right heart failure in Tibetan children living in high altitude area

(2020) Jiayun Yu et al.   MEDICINE

Hypoxia-inducible factor signaling in pulmonary hypertension

(2020) Soni Savai Pullamsetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevalence and Risk Factors for COPD at High Altitude: A Large Cross-Sectional Survey of Subjects Living Between 2,100–4,700 m Above Sea Level

(2020) Yanfei Guo et al.   Frontiers in Medicine

Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population

(2019) Djuro Kosanovic et al.   Frontiers in Physiology

Rheumatic heart disease in the modern era: recent developments and current challenges

(2019) Matheus Tozatto Baptista Coelho Leal et al.   Revista da Sociedade Brasileira de Medicina Tropical

Clinical characteristics of pulmonary hypertension patients living in plain and high‐altitude regions

(2019) Si Lei et al.   Clinical Respiratory Journal

Pulmonary artery pressure at rest and during exercise in Chronic Mountain Sickness: a meta-analysis

(2019) Rodrigo Soria et al.   EUROPEAN RESPIRATORY JOURNAL

Convergent evolution in human and domesticate adaptation to high-altitude environments

(2019) Kelsey E. Witt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update

(2019) Andrew M. Luks et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension

(2019) Cheng-Jun Hu et al.   EUROPEAN RESPIRATORY JOURNAL

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

(2018) Zhiyu Dai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Rho kinase inhibitor fasudil on the expression ET-1 and NO in rats with hypoxic pulmonary hypertension

(2018) Xing-Zhen Sun et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching

(2018) Virginia Chamorro et al.   PLoS One

Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review

(2018) Martin Burtscher et al.   Frontiers in Physiology

Newborn screening for congenital heart disease using echocardiography and follow-up at high altitude in China

(2018) Jing-Jing Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

(2018) Nina Rol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Advances in the available non-biological pharmacotherapy prevention and treatment of acute mountain sickness and high altitude cerebral and pulmonary oedema

(2018) K.E. Joyce et al.   EXPERT OPINION ON PHARMACOTHERAPY

Dexamethasone improves pulmonary hemodynamics in COPD-patients going to altitude: A randomized trial

(2018) Mona Lichtblau et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

High prevalence of congenital heart disease at high altitudes in Tibet

(2018) Hua Chun et al.   European Journal of Preventive Cardiology

Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again

(2018) Kurt W. Prins et al.   Journal of the American Heart Association

Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m)

(2017) Andrew M. Luks et al.   EXPERIMENTAL PHYSIOLOGY

Remote ischemic preconditioning does not prevent acute mountain sickness after rapid ascent to 3,450 m

(2017) Marc M. Berger et al.   JOURNAL OF APPLIED PHYSIOLOGY

Recent advances in oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

(2017) Ievgen Strielkov et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary hypertension with warm hands

(2017) Liza Botros et al.   THORAX

High Altitude Pulmonary Edema in a Mining Worker With an Abnormal Rise in Pulmonary Artery Pressure in Response to Acute Hypoxia Without Prior History of High Altitude Pulmonary Edema

(2017) Almaz Ch. Akunov et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

(2017) Lloyd Harvey et al.   Journal of Clinical Medicine

Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs

(2016) Nandy C. Lopez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE

(2016) Zhiyu Dai et al.   CIRCULATION

RhoA/Rho-Kinase in the Cardiovascular System

(2016) Hiroaki Shimokawa et al.   CIRCULATION RESEARCH

Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment

(2016) Francisco C. Villafuerte et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

The Effects of Sex on Cardiopulmonary Responses to Acute Normobaric Hypoxia

(2016) Christopher John Boos et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Effect of Increased Blood Flow on Pulmonary Circulation Before and During High Altitude Acclimatization

(2016) Matthias Peter Hilty et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia

(2016) Nicole K. Bart et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis

(2016) Rodrigo Soria et al.   JOURNAL OF APPLIED PHYSIOLOGY

Clinical iron deficiency disturbs normal human responses to hypoxia

(2016) Matthew C. Frise et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary arterial hypertension associated with a von Hippel-Lindau gene mutation

(2016) Sergio Caravita et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice

(2016) Pinelopi P. Kapitsinou et al.   MOLECULAR AND CELLULAR BIOLOGY

HIF2α–arginase axis is essential for the development of pulmonary hypertension

(2016) Andrew S. Cowburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of perinatal, late foetal, and early embryonic insults on the cardiovascular phenotype in experimental animal models and humans

(2016) Theo Arthur Meister et al.   Vasa-European Journal of Vascular Medicine

Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling

(2016) Shuo Wang et al.   Oncotarget

A global view of pulmonary hypertension

(2016) Marius M Hoeper et al.   Lancet Respiratory Medicine

Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction

(2015) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pathophysiology and Treatment of High-Altitude Pulmonary Vascular Disease

(2015) M. R. Wilkins et al.   CIRCULATION

Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat

(2015) E. Cotroneo et al.   CIRCULATION RESEARCH

Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

(2015) Natascha Sommer et al.   EUROPEAN RESPIRATORY JOURNAL

Exaggerated pulmonary vascular response to acute hypoxia in older men

(2015) George M. Balanos et al.   EXPERIMENTAL PHYSIOLOGY

Exaggerated Hypoxic Pulmonary Vasoconstriction Without Susceptibility to High Altitude Pulmonary Edema

(2015) Christoph Dehnert et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

High altitude-induced borderline pulmonary hypertension impaired cardiorespiratory fitness in healthy young men

(2015) Te Yang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Right ventricular dysfunction in children and adolescents conceived by assisted reproductive technologies

(2015) Robert von Arx et al.   JOURNAL OF APPLIED PHYSIOLOGY

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

(2015) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans

(2015) Marzieh Fatemian et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension

(2015) John H. Newman et al.   Nature Communications

Prevalence, Clinical Profile, Iron Status, and Subject-Specific Traits for Excessive Erythrocytosis in Andean Adults Living Permanently at 3,825 Meters Above Sea Level

(2014) Aldo De Ferrari et al.   CHEST

Hypoxic pulmonary hypertension: the paradigm is changing

(2014) S. C. Rowan et al.   EXPERIMENTAL PHYSIOLOGY

Human high-altitude adaptation: forward genetics meets the HIF pathway

(2014) Abigail W. Bigham et al.   GENES & DEVELOPMENT

Ischemic Preconditioning Improves Oxygen Saturation and Attenuates Hypoxic Pulmonary Vasoconstriction at High Altitude

(2014) Gary P. Foster et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Acute hemodynamic response of infused fasudil in patients with pulmonary arterial hypertension: A randomized, controlled, crossover study

(2014) Xin Jiang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas

(2014) Glen E. Foster et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

The homozygousVHLD126Nmissense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension

(2014) Susmita Sarangi et al.   PEDIATRIC BLOOD & CANCER

Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2014 Update

(2014) Andrew M. Luks et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension

(2013) Monika Malczyk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Mechanisms and Drug Therapy of Pulmonary Hypertension at High Altitude

(2013) Urs Scherrer et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Pulmonary Hypertension and Chronic Mountain Sickness

(2013) Robert Naeije et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Classical Transient Receptor Potential 1 and 6 Contribute to Hypoxic Pulmonary Hypertension Through Differential Regulation of Pulmonary Vascular Functions

(2013) Yang Xia et al.   HYPERTENSION

High altitude pulmonary hypertension with severe right ventricular dysfunction

(2013) Abdirashit Maripov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia

(2013) Nayia Petousi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary circulation and gas exchange at exercise in Sherpas at high altitude

(2013) Vitalie Faoro et al.   JOURNAL OF APPLIED PHYSIOLOGY

Erythrocytosis and Pulmonary Hypertension in a Mouse Model of HumanHIF2AGain of Function Mutation

(2013) Qiulin Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haematological Changes at Altitude

(2013) K. Wheatley et al.   Journal of the Royal Army Medical Corps

High-Altitude Medicine

(2012) John B. West   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition

(2012) Lei Zhang et al.   CELLULAR SIGNALLING

Systemic and Pulmonary Vascular Dysfunction in Children Conceived by Assisted Reproductive Technologies

(2012) Urs Scherrer et al.   CIRCULATION

Acetazolamide and chronic hypoxia: effects on haemorheology and pulmonary haemodynamics

(2012) Aurélien Pichon et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of fasudil in patients with high-altitude pulmonary hypertension

(2012) B. Kojonazarov et al.   EUROPEAN RESPIRATORY JOURNAL

The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally

(2012) Edwina Cahill et al.   EXPERIMENTAL PHYSIOLOGY

The Effects of Acute Hypobaric Hypoxia on Arterial Stiffness and Endothelial Function and its Relationship to Changes in Pulmonary Artery Pressure and Left Ventricular Diastolic Function

(2012) C.J. Boos et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents

(2012) Baktybek Kojonazarov et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells

(2012) Yun Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cardiovascular Disease in the Developing World

(2012) David S. Celermajer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Notch Signaling Change in Pulmonary Vascular Remodeling in Rats with Pulmonary Hypertension and Its Implication for Therapeutic Intervention

(2012) Lina Qiao et al.   PLoS One

Nifedipine for the Treatment of High Altitude Pulmonary Edema

(2012) Rajesh Deshwal et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Management of High Altitude Pulmonary Edema in the Himalaya: A Review of 56 Cases Presenting at Pheriche Medical Aid Post (4240 m)

(2012) Barbara E. Jones et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Bosentan Effects in Hypoxic Pulmonary Vasoconstriction: Preliminary Study in Subjects with or without High Altitude Pulmonary Edema-History

(2012) Isabelle Pham et al.   Pulmonary Circulation

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

(2011) J. Bond et al.   BLOOD

Effects of epoprostenol and sildenafil on right ventricular function in hypoxic volunteers: a tissue Doppler imaging study

(2011) Adriana Pavelescu et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia)

(2011) C. A. Sable et al.   HAEMATOLOGICA

Long-acting phosphodiesterase 5 inhibitor, tadalafil, and superoxide dismutase mimetic, tempol, protect against acute hypoxia-induced pulmonary hypertension in rats

(2011) M Rashid et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Improvement in lung diffusion by endothelin A receptor blockade at high altitude

(2011) Claire de Bisschop et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary Vascular Resistance and Viscosity: The Forgotten Factor

(2011) Julien I. E. Hoffman   PEDIATRIC CARDIOLOGY

Ischemic preconditioning of the lower extremity attenuates the normal hypoxic increase in pulmonary artery systolic pressure

(2011) Gary P. Foster et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Wilderness Medical Society Consensus Guidelines for the Prevention and Treatment of Acute Altitude Illness

(2011) Andrew M. Luks et al.   WILDERNESS & ENVIRONMENTAL MEDICINE

Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers With Preeclampsia

(2010) Pierre-Yves Jayet et al.   CIRCULATION

Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans

(2010) I. Pham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Pulmonary artery pressure limits exercise capacity at high altitude

(2010) R. Naeije et al.   EUROPEAN RESPIRATORY JOURNAL

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

(2010) Hiroshi Fujita et al.   HEART AND VESSELS

The Impact of Moderate-Altitude Staging on Pulmonary Arterial Hemodynamics after Ascent to High Altitude

(2010) Aaron L. Baggish et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Altitude Preexposure Recommendations for Inducing Acclimatization

(2010) Stephen R. Muza et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability

(2010) Damian M. Bailey et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeting non-malignant disorders with tyrosine kinase inhibitors

(2010) Friedrich Grimminger et al.   NATURE REVIEWS DRUG DISCOVERY

The PPARβ/δAgonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension

(2010) Louise S. Harrington et al.   PLoS One

Hypoxia-induced changes in pulmonary and systemic vascular resistance: Where is the O2 sensor?

(2010) Gregory B. Waypa et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Rosiglitazone attenuates hypoxia-induced pulmonary arterial hypertension in rats

(2010) Eun Kyung KIM et al.   RESPIROLOGY

Echocardiographic and Tissue Doppler Imaging of Cardiac Adaptation to High Altitude in Native Highlanders Versus Acclimatized Lowlanders

(2009) Sandrine Huez et al.   AMERICAN JOURNAL OF CARDIOLOGY

Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment

(2009) Danielle L. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dexamethasone But Not Tadalafil Improves Exercise Capacity in Adults Prone to High-Altitude Pulmonary Edema

(2009) Manuel Fischler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model

(2009) Rachel E. Nisbet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bosentan Decreases Pulmonary Vascular Resistance and Improves Exercise Capacity in Acute Hypoxia

(2009) Vitalie Faoro et al.   CHEST

Exaggerated Pulmonary Hypertension During Mild Exercise in Chronic Mountain Sickness

(2009) Thomas Stuber et al.   CHEST

Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension

(2009) Ekkehard Grünig et al.   CIRCULATION

Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats

(2009) C. Bai et al.   EUROPEAN RESPIRATORY JOURNAL

Effect of Six Days of Staging on Physiologic Adjustments and Acute Mountain Sickness during Ascent to 4300 Meters

(2009) Beth A. Beidleman et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension

(2009) Thomas G. Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Acetazolamide for Monge's Disease

(2008) Jean-Paul Richalet et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Pulmonary Pressure and Cardiac Function in Chronic Mountain Sickness Patients

(2008) Maxime Maignan et al.   CHEST

Pulmonary-Artery Pressure and Exhaled Nitric Oxide in Bolivian and Caucasian High Altitude Dwellers

(2008) Marcos Schwab et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Pulmonary Hemodynamics in Children Living at High Altitudes

(2008) Dante Penaloza et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Effect of Ascent Protocol on Acute Mountain Sickness and Success at Muztagh Ata, 7546 m

(2008) Konrad E. Bloch et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Transpulmonary Plasma ET-1 and Nitrite Differences in High Altitude Pulmonary Hypertension

(2008) Marc M. Berger et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prophylactic bosentan does not improve exercise capacity or lower pulmonary artery systolic pressure at high altitude

(2008) Roger D. Seheult et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

(2007) David B. Frank et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Downregulation of Angiopoietin-1 and Tie2 in Chronic Hypoxic Pulmonary Hypertension

(2007) Akihito Yamamoto et al.   RESPIRATION