Article
Physiology
Marc Moritz Berger, Mahdi Sareban, Lisa Maria Schiefer, Kai E. Swenson, Franziska Treff, Larissa Schafer, Peter Schmidt, Magdalena M. Schimke, Michael Paar, Josef Niebauer, Annalisa Cogo, Susi Kriemler, Stefan Schwery, Philipp A. Pickerodt, Benjamin Mayer, Peter Bartsch, Erik R. Swenson
Summary: Acetazolamide is not recommended for prevention of high-altitude pulmonary edema (HAPE) in mountaineers ascending rapidly to over 4,500 m, despite its ability to alleviate symptoms of acute mountain sickness (AMS) and improve arterial oxygenation.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Tianbo Jin, Hongyan Lu, Zhanhao Zhang, Yuliang Wang, Wei Yang, Yuhe Wang, Xue He, Dongya Yuan, Yongjun He
Summary: Research has found that HAPE patients have abnormal DNA methylation at multiple CpG sites in the promoter regions of the CYP2S1 gene. Among these sites, the higher risk of hypermethylation was observed at CYP2S1_1_CPG_1.2.3, and the methylation level of CYP2S1 could effectively predict the risk of HAPE patients.
Article
Pediatrics
K. Elisabeth Runte, Jonathan N. Flyer, Erika M. Edwards, Roger F. Soll, Jeffrey D. Horbar, Scott B. Yeager
Summary: The study found that while VLBW infant populations are largely uniform, there is wide variation in PDA treatment. Treatment rates decreased over the study period, with significant differences in treatment rates among different hospitals, which were correlated with hospital treatment capabilities and geography.
Article
Pharmacology & Pharmacy
Kannan Sridharan, Eman Al Ansari, Mwila Mulubwa, Arun Prasath Raju, Abdulraoof Al Madhoob, Muna Al Jufairi, Zakariya Hubail, Reem Al Marzooq, Sadeq Jaafar Radhi Hasan, Surulivelrajan Mallaysamy
Summary: This study conducted a population pharmacokinetic-pharmacodynamic modeling of acetaminophen in preterm neonates with hemodynamically significant PDA, indicating that a dose of 20 mg/kg intravenously every six hours is likely to offer better therapeutic effects than the current dosing regimen.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Respiratory System
Josephat M. Chinawa, Bartholomew F. Chukwu, Awoere T. Chinawa, Chika O. Duru
Summary: The study showed that 60.2% of children with PDA had pulmonary hypertension, with females being 1.8 times more likely to have it than males. There was a positive correlation between ductal size and PASP, with larger ducts associated with more severe pulmonary hypertension.
BMC PULMONARY MEDICINE
(2021)
Article
Pediatrics
Tim Hundscheid, Afif El-Khuffash, Patrick J. McNamara, Willem P. de Boode
Summary: The survey highlights the lack of guidelines and significant heterogeneity in current practice. The current evidence is not sufficient to harmonize the current treatment strategies into (inter)national guidelines.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Evolutionary Biology
Peter Woods, Joe Alcock
Summary: High Altitude Pulmonary Edema (HAPE) is a potentially fatal disease of altitude characterized by fluid filling the lungs, which can be seen as a condition of a mismatch between current environment and evolutionary experience.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)
Article
Pharmacology & Pharmacy
K. Sridharan, A. Al Madhoob, M. Al Jufairi, E. Al Ansari, R. Al Marzooq
Summary: The study results demonstrated controversial effects of concomitant frusemide with acetaminophen therapy in neonates with PDA, but no significant influence was observed in outcomes of acetaminophen therapy with concomitant frusemide in preterm neonates with PDA.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pediatrics
Petra Lemmers, Daniel Vijlbrief, Manon Benders, Thomas Alderliesten, Moniek Veldhuis, Wim Baerts, Corine Koopman-Esseboom, Floris Groenendaal, Frank van Bel
Summary: This study investigated the relationship between the duration of patency of the ductus arteriosus (PDA), cerebral oxygenation, magnetic resonance imaging-determined brain growth, and neurodevelopmental outcome in preterm infants. The results showed that a prolonged duration of PDA was associated with reduced cerebellar growth and suboptimal neurodevelopmental outcome at the age of 2 years.
JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Matthew Clark, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: In extremely preterm infants on respiratory support on postnatal day 28, the presence and longer duration of patent ductus arteriosus (PDA) were associated with the development of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Biophysics
Timothy D. Kelly, Maxene Meier, Jason P. Weinman, Dunbar Ivy, John T. Brinton, Deborah R. Liptzin
Summary: This study aimed to characterize the radiographic patterns of pediatric high-altitude pulmonary edema (HAPE) and understand the ongoing risk following an initial HAPE episode. The majority of pediatric HAPE cases showed right-sided and upper lobe involvement, with some children experiencing recurrent episodes.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Elchanan Bruckheimer, Kristoffer Steiner, Yuval Barak-Corren, Leonel Slanovic, Michael Levinzon, Alexander Lowenthal, Gabriel Amir, Tamir Dagan, Einat Birk
Summary: Evaluated the use of Piccolo and ADOII devices for transcatheter closure of patent ductus arteriosus (PDA), with Piccolo having smaller retention discs reducing the risk of flow disturbance but potentially increasing the risk of residual leak and embolization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pediatrics
Sarah Parkerson, Ranjit Philip, Ajay Talati, Shyam Sathanandam
Summary: PDA, the most commonly found cardiac condition in neonates, still sparks debate among healthcare professionals due to the lack of long-term benefits with interventions studied. This article briefly summarizes the history, embryology, and histology of PDA, discusses its hemodynamic significance, and introduces TCPC as a possible solution for this age-old problem.
FRONTIERS IN PEDIATRICS
(2021)
Article
Acoustics
D. P. Ngwezi, M. McClean, A. McBrien, L. Eckersley, J. Abeysekera, T. Colen, L. K. Hornberger
Summary: The inability to visualize branch pulmonary arteries in the same plane, often associated with abnormal ductus arteriosus insertion, and/or a posterior pulmonary artery bifurcation angle of >= 105 degrees are predictive features of postnatal ductus arteriosus-related branch pulmonary stenosis in fetuses with pulmonary atresia.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fumiya Yoneyama, Michiaki Imamura, Manish Bansal, Athar M. Qureshi, Jeffery S. Heinle
Summary: Treating large patent ductus arteriosus (PDA) in the presence of pulmonary hypertension (PHTN) is challenging and requires comprehensive management for assessing pulmonary vascular reactivity and timing of PDA closure. In this case report, we present a severe PHTN associated with pulmonary venous stenosis, which was successfully treated with staged PDA banding for eventual PDA occlusion.
PROGRESS IN PEDIATRIC CARDIOLOGY
(2023)